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Estrogen and Antiestrogen Resistance in Human Breast Cancer Cell Lines

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Steroid Hormone Resistance

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 196))

Abstract

Despite nearly a century of awareness of the efficacy of various kinds of endocrine therapies in the management of patients with metastatic breast cancer, many facets of the mechanisms whereby hormones influence the growth of neoplastic tissue remain incompletely understood. Since the initial discovery in 1971 by Jensen et al1 that some breast cancers contain estrogen receptors, substantial progress has been made in understanding the critical role of these hormone binding sites in metabolism and neoplastic growth and in characterizing how these receptors are capable of interacting with nuclear material and activating transcription of specific genes.2,3 Many studies have shown that there is an excellent correlation between the presence of estrogen receptor activity and hormone triggered growth responses in breast tumors.4 Anti-estrogen or high dose estrogen mediated cytotoxicity of breast cancer also requires the presence of an estrogen receptor. Specifically, if the tumor lacks estrogen receptor the chance of seeing an objective response to endocrine therapy is only 5 percent or less. On the other hand, if the tumor contains receptor then the likelihood of a response to endocrine therapy is approximately 50 to 60 percent. Thus, there is a subset of patients who, despite the presence of estrogen binding activity, fail to show a response to endocrine therapy. The present article summarizes current information on cell culture models for this disease entity.

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Authors and Affiliations

  1. Medical Breast Cancer Section, National Cancer Institute National Institutes of Health, Bethesda, Maryland, 20205, USA

    D. A. Bronzert, N. Davidson & M. Lippman

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  1. D. A. Bronzert
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  2. N. Davidson
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  3. M. Lippman
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Editors and Affiliations

  1. National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA

    George P. Chrousos , D. Lynn Loriaux  & Mortimer B. Lipsett ,  & 

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© 1986 Plenum Press, New York

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Bronzert, D.A., Davidson, N., Lippman, M. (1986). Estrogen and Antiestrogen Resistance in Human Breast Cancer Cell Lines. In: Chrousos, G.P., Loriaux, D.L., Lipsett, M.B. (eds) Steroid Hormone Resistance. Advances in Experimental Medicine and Biology, vol 196. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5101-6_22

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  • DOI: https://doi.org/10.1007/978-1-4684-5101-6_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5103-0

  • Online ISBN: 978-1-4684-5101-6

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