Abstract
Increased life expectancy in the developed countries has highlighted the problems raised by both the normal and especially the pathological ageing processes of the brain. One problem in particular in terms of its socio-economic impact is represented by the senile dementia of the Alzheimer type (SDAT). It has been estimated that this disease represents the fourth or fifth main cause of death in the developed countries. The SDAT syndrome is characterized initially by temporo-spatial disturbances and impairment of recent memory followed by language disorders (aphasia), dysfunction of motor skill (apraxia) and perceptual difficulties (agnosia).
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References
Bartus, R.T., Dean, R.L., Beer, B., and Lippa, A.S., 1982, The cholinergic hypothesis of geriatric memory dysfunction, Science, 217: 408.
Bowen, D.M., Smith, C.B., White, P., and Davidson, A.N., 1976, Neuro-transmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies, Brain, 99: 459.
Coyle, J.T., Price, D.L., and Delong, M.R., 1983, Alzheimer’s disease: a disorder of cortical cholinergic innervation, Science, 219: 1184.
Davies, P., and Verth, A.H., 1978, Regional distribution of muscarinic acetylcholine receptor in normal and Alzheimer’s type dementia brains, Brain Res., 138: 395.
Davis, P.E., and Mumford, S.J., 1984, Cued recall and the nature of the memory disorder in dementia, Brit. J. Psychiat., 144: 383.
Dubois, B., Mayo, W., Agid, Y., Le Moal, M., and Simon, H., 1985, Profound disturbances of spontaneous and learned behaviors following lesions of the nucleus basalis magnocellularis in the rat, Brain Res., in press.
Flicker, C., Dean, R.L., Watkins, D.L., Fisher, S.K., and Bartus, R.T., 1983, Behavioral and neurochemical effects following neurotoxic lesions of a major cholinergic input to the cerebral cortex in the rat, Pharmacol. Biochem. Behav., 18: 973.
Friedman, E., Lerer, B., and Kuster, J., 1982, Loss of cholinergic neurons in the rat neocortex produces deficits in passive avoidance learning, Pharmacol. Biochem. Behav., 19: 309.
Johnston, M.V., McKinney, M., and Coyle, J.T., 1979, Evidence for a cholinergic projection to neocortex from neurons in the basal forebrain, Proc. Nat. Acad. Sci., 76: 5392.
Lo Conte, G., Bartolini, L., Casamenti, F. and Marconcini-Pepeu, G., 1982, Lesions of cholinergic forebrain nuclei: changes in avoidance behavior and scopolamine actions. Pharmacol. Biochem. Behav., 17: 933.
Mayo, W., Dubois, B., Ploska, A., Javoy-Agid, F., Agid, Y., Le Moal, M., and Simon, H., 1984, Cortical cholinergic projections from the basal forebrain of the rat, with special reference to the prefrontal cortex innervation, Neurosci. Lett., 47: 149.
Olton, D.S., and Samuelson, R.J., 1976, Remembrance of places passed: spatial memory in rats, J. Exp. Psychol., 2: 97.
Perry, E.K., Perry, R.H., Blessed, G., and Tomlinson, B.E., 1977, Necropsy evidence of central cholinergic deficits in senile dementia, Lancet, 1: 189.
Perry, E.K., Tomlinson, B.E., Blessed, G., Bergmann, K., Gibson, P.H., and Perry, R.H., 1978, Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia, Br. Med. J., 2: 1457.
Pilleri, G., 1966, The Kluver-Bucy syndrome in man. A clinico-anatomical contribution to the function of the medial temporal lobe structures, Psychiat. Neurol., 152: 65.
Rossor, M.N., Emson, P.C., Mountjoy, C.Q., Roth, M. and Iversen, L.L., 1980, Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of the Alzheimer type, Neurosci. Lett., 20: 373.
Rossor, M.N., Svendson, C., Hunt, C.P., Mountjoy, C.Q., Roth, M. and Iversen, L.L. 1982, The substantia innominata in Alzheimer’s disease: an histochemical and biochemical study of cholinergic marker enzymes, Neurosci. Lett., 28: 217.
Salamone, J.D., Beart, P.M., Alpert, J.E., and Iversen, S.D., 1984, Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats, Behav. Brain Res., 13: 63.
Sims, N.R., Bowen, D.M., Allen, S.J., Smith, C.C.T., Neary, D., Thomas, D.J., and Davison, A.N., 1983, Presynaptic cholinergic dysfunction in patients with dementia, J. Neurochem., 40: 503.
Whitehouse, P.J., Price, D.L., Clark, A.W., Coyle, J.T., and Delong, M.R., 1981, Alzheimers disease: evidence for selective loss of cholinergic neurons in the nucleus basalis, Ann. Neurol., 10: 122.
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© 1985 Plenum Press, New York
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Simon, H., Mayo, W., Le Moal, M. (1985). Anatomical and Behavioral Studies Following Lesions on the Basal Magnocellular Nucleus in the Rat. In: Will, B.E., Schmitt, P., Dalrymple-Alford, J.C. (eds) Brain Plasticity, Learning, and Memory. Advances in Behavioral Biology, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5003-3_43
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DOI: https://doi.org/10.1007/978-1-4684-5003-3_43
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