Anatomical and Behavioral Studies Following Lesions on the Basal Magnocellular Nucleus in the Rat
Increased life expectancy in the developed countries has highlighted the problems raised by both the normal and especially the pathological ageing processes of the brain. One problem in particular in terms of its socio-economic impact is represented by the senile dementia of the Alzheimer type (SDAT). It has been estimated that this disease represents the fourth or fifth main cause of death in the developed countries. The SDAT syndrome is characterized initially by temporo-spatial disturbances and impairment of recent memory followed by language disorders (aphasia), dysfunction of motor skill (apraxia) and perceptual difficulties (agnosia).
KeywordsLocomotor Activity Senile Dementia Radial Maze Neuritic Plaque Ibotenic Acid
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