Advertisement

Cholecystokinin, Learning and Memory

  • Gyula Telegdy
  • Tibor Kádár
  • Mátyás Fekete
Part of the Advances in Behavioral Biology book series (ABBI, volume 28)

Abstract

The presence of cholecystokinins (CCK-s) in the central nervous system has been well established (Rehfeld 1977, Dockray et al., 1978, Müller et al., 1978) In recent years, a large number of data have accumulated demonstrating many different actions of CCK-s on brain functions. Nevertheless the physiological significance of brain CCK-s is still poorly understood.

Keywords

Passive Avoidance Retrograde Amnesia Learning Trial Passive Avoidance Task Brain Monoamine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Ader, R., and De Wied, D., 1972, Effects of vasopressin on active and passive avoidance learning, Psychon. Sci., 29:46.Google Scholar
  2. Crawley, J. N., Hays, S. E., Paul, M. S., and Goodwin, F. K., 1981, Cholecystokinin reduces exploratory behaviour in mice, Physiol. Behav. 27:407.CrossRefGoogle Scholar
  3. Dockray, G. J., Gregory, R. A., Hutchison, J. B., Harris, J. I., and Ruswick, M. J., 1978, Isolation, structure and biological activity of two cholecystokinin octapeptides from sheep brain, Nature 274:711.CrossRefGoogle Scholar
  4. Fekete, M., Balázs, M., Penke, B., and Telegdy, G., 1981a, Influence of sulfated and unsulfated cholecystokinin octapeptide on conditioned feeding behaviour in rats. Peptides. 2:385.CrossRefGoogle Scholar
  5. Fekete, M., Bokor, M., Penke, B., Kovács, K., and Telegdy, G., 1981b, Effects of cholecystokinin octapeptide and its fragments on brain monoamines and plasma corticosterone. Neurochem. Intern., 3:165.CrossRefGoogle Scholar
  6. Fekete, M., Kádár, T., Penke, B., Kovács, K., and Telegdy, G., 1981c, Influence of cholecystokinin octapeptide sulfate ester on brain monoamine metabolism in rats. J. Neural Transmission, 50:81.CrossRefGoogle Scholar
  7. Fekete, M., Kádár, T., Penke, B., and Telegdy, G., 1981d, Modulation of passive avoidance behaviour by cholecystokinin octapeptides in rats, Neuropeptides, 1:301.CrossRefGoogle Scholar
  8. Fekete, M., Szabó, A., Balázs, M., Penke, B., and Telegdy, G., 1981e, Effects of intraventricular administration of cholecystokinin octapeptide sulfate ester and unsulfated cholecystokinin octapeptide on active avoidance and conditioned feeding behaviour of rats. Acta Physiol. Acad.Sci.Hung. 58:39.Google Scholar
  9. Fekete, M., Várszegi, M., Kádár, T., Penke, B., Kovács, K., and Telegdy, G., 1981f, Effect of cholecystokinin octapeptide sulphate ester on brain monoamines in the rat. Acta Physiol, Acad, Sci. Hung. 57:37.Google Scholar
  10. Fekete, M., Bokor, M., Penke, B., and Telegdy, G., 1982, Effects of cholecystokinin octapeptide sulphate ester and unsulphated cholecystokinin octapeptide on active avoidance behaviour in rats, Acta Physiol. Acad.Sci. Hung. 60:57.Google Scholar
  11. Fekete, M., Lengyel, A., Hegedüs, B., Penke, B., Zarándi, M., Tóth, G., Telegdy, G., 1984. Further analysis of the effects of cholecystokinin octapeptides on avoidance behaviour in rats, Eur. 3. Pharmacol. 98:79.CrossRefGoogle Scholar
  12. Itoh, S., Katsuura, G., 1981, Sedative action of intracerebroventricu lar ly administered cholecystokinin in the rat, Neurosci Lett, Suppl. 7. S323.Google Scholar
  13. Kádár, T., Fekete, M., and Telegdy, G., 1981, Modulation of passive avoidance behavior of rats by intracerebroventricular administration of cholecystokinin octapeptide sulfate ester and nonsulfated cholecystokinin octapeptide. Acta Physiol. Acad.Sci.Hung. 58:269.Google Scholar
  14. Kádár, T., Pesti, A., Penke, B., Telegdy, G., 1984, Inhibition of Picrotoxin and electroshock-induced seizures by cholecystokinin octapeptides and their fragments in Neuropharmacology, 23:955.Google Scholar
  15. Muller, J. E., Strauss, E., and Yalow, R. S., 1978, Cholecystokinin and its COOH-terminal octapeptide in the pig brain, Proc.Natl. Acad.Sci. USA 75:486.CrossRefGoogle Scholar
  16. Rehfeld, J. F., 1977, Cholecystokinins and gastrin in brain and gut, Acta pharmac, toxicol., 41:24.Google Scholar
  17. Telegdy, G., 1981, The effect of neurohormones on the brain and endocrine system. Acta Phys.Acad.Sci. Hung. 55:273.Google Scholar
  18. Telegdy, G., 1982, Hormone-induced alterations in brain transmitter metabolism and brain function. Endocr. Exper. 16:217.Google Scholar
  19. Telegdy, G., Fekete, M., Kádár, T., 1982, Cholecystokinin in the brain, Intern. Med. 2:2.Google Scholar
  20. Telegdy, G., Hadnagy, O., Lissák, K., 1968, The effect of gonads on conditioned avoidance behavior of rats. Acta Physiol. Acad.Sci.Hung. 33:439.Google Scholar
  21. Telegdy, G., Fekete, M., and Várszegi, M., 1979, Effects of peptide hormone on the neurotransmitter metabolism of the central nervous system. In: “Recent Results in Peptide Hormone and Androgenic Steroid Research”, F. A. László, ed., Akadémiai Kiadó, Budapest.Google Scholar
  22. Telegdy, G., Fekete, M., Várszegi, M., and Kádár, T., 1980, Effect of peptide hormones on biogenic amines of the central nervous system, In: Advances in Pharmacological Research and Practice. Gen.ed., J. Knoll, Vol.VII. Aminergic and peptidergic receptors eds.: E. S. Vizi and M. Wolleman, Pergamon Press.Akadémiai Kiadó, Budapest.Google Scholar
  23. Van Ree, D. M., Gaffori, O., and De Wied, D., 1983, In rats the behavioural profile of CCK-8 related peptides resembles that of antipsychotic agents, Eur. 3. Pharmacol. 93:63.Google Scholar
  24. Worms, P., Broekkamp, L. E., and Lloyd, K. G., 1983, Behavioral effects of neuroleptics, in: “Neuroleptics: Neurochemical, Behavioral and Clinical Perspectives”. G. T. Coyle and S. J. Enna, eds., Raven Press, New York.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Gyula Telegdy
    • 1
  • Tibor Kádár
    • 1
  • Mátyás Fekete
    • 1
  1. 1.Inst, of PathophysiologyUniv. Med. SchoolSzegedHungary

Personalised recommendations