Skip to main content

Role of the Locus Coeruleus System in Behavioral Plasticity

  • Chapter
Brain Plasticity, Learning, and Memory

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 28))

  • 178 Accesses

Abstract

In previous studies we showed that electrical stimulation of the lateral hypothalamus of 15 day old rats significantly enhanced the learning of various tasks examined 4 weeks later. We first demonstrated that this stimulation improved the acquisition and extinction of a food-reinforced task (Velley and Cardo, 1977). In subsequent experiments, we observed the same effect on the acquisition and reversal of a light-dark discrimination whether appetitively or aversively reinforced as well as on the acquisition of a one way avoidance task (Velley et al., 1981b).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Amaral, D.G., and Foss, J.A., 1975, Locus coeruleus lesions and learning, Science, 188:377.

    Article  Google Scholar 

  • Amaral, D.G., and Sinnamon, H.M., 1977, The locus coeruleus: Neurobiology of a central noradrenergic nucleus, Progr. Neurobiol., 9:147.

    Article  Google Scholar 

  • Anisman, H., 1978, Neurochemical changes elicited by stress. Behavioral correlates, in: “Psychopharmacology of aversively motivated behavior”, A. Anisman and G. Bignami, eds., Plenum Press, N.Y.

    Chapter  Google Scholar 

  • Anlezark, G.M., Crow, T.J., and Greenway, A.P., 1973, Impaired learning and decreased cortical norepinephrine after bilateral locus coeruleus lesions, Science, 181:682.

    Article  Google Scholar 

  • Aston-Jones, G., and Bloom, F.E., 1981, Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli, J. Neurosci., 1:887.

    Google Scholar 

  • Bassett, J.R., and Cairncross, K.D., 1973, Parameters of novelty, shock predictability and response contingency in corticosterone release in the rat, Physiol. Behav., 10:901.

    Article  Google Scholar 

  • Cedarbaum, J.M., and Aghajanian, C.K., 1978, Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique, J. Comp. Neurol., 178:1.

    Article  Google Scholar 

  • Clark, T.K., 1979, The locus coeruleus in behavioral regulation: evidence for behavior-specific versus general involvement, Behav. Neur. Biol., 25:271.

    Article  Google Scholar 

  • Coover, G.D., Goldman, L., and Levine, S., 1971, Plasma corticosterone increases produced by extinction of operant behavior in rats, Physiol. Behav., 6:261.

    Article  Google Scholar 

  • Crow, T.J., 1968, Cortical synapses and reinforcement: A hypothesis, Nature, 219:736.

    Article  Google Scholar 

  • Crow, T.J., Deakin, J.F.W., File, S.E., Longden, A., and Wendlandt, S., 1978, The locus coeruleus noradrenergic system. Evidence against a role in attention, habituation, anxiety and motor activity, Brain Res., 155:249.

    Article  Google Scholar 

  • Davis, H., Memmott, J., McFadden, L., and Levine, S., 1976, Pituitary-adrenal activity under different appetitive extinction procedures. Physiol. Behav., 17:687.

    Article  Google Scholar 

  • Engel, G., Hoyer, D., Berthold, R., and Wagner, H., 1981,(I)125iodocyano-pindolol, a new ligand for beta-adrenoceptors: identification and quantification of subclasses of beta-adrenoceptors in guinea-pig, Naunyn-Schmiedeberg Arch. Pharmacol., 317:277.

    Article  Google Scholar 

  • File, S.A., and Peet, L.A., 1980, The sensitivity of the rat corticosterone response to environmental manipulations and to chronic chlordiazepoxyde treatment, Physiol. Behav., 25:753.

    Article  Google Scholar 

  • Foote, S.L., Aston-Jones, G., and Bloom, F.E., 1980, Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal, Proc.Nat. Acad. Sci. U.S., 77:3033.

    Article  Google Scholar 

  • Hennessy, M.B., Heybach, J.P., Vernicos, J., and Levine, S., 1979, Plasma corticosterone concentrations sensitively reflect levels of stimulus intensity in the rat, Physiol. Behav., 22:821.

    Article  Google Scholar 

  • Heybach, J.P., Coover, G.D., and Lints, C.E., 1978, Behavioral effects of neurotoxic lesions of the ascending monoamine pathways in the rat brain, J. comp. physiol. Psychol., 92:58.

    Article  Google Scholar 

  • Koob, G., Kelley, A.E., and Mason, S.T., 1978, Locus coeruleus lesions: learning and extinction, Physiol. Behav., 20:709.

    Article  Google Scholar 

  • Levine, S., Goldman, L., and Cooper, G.D., 1972, Expectancy and the pituitary-adrenal system, in: “Ciba Foundation Symposium”, 8: Elsevier, Amsterdam.

    Google Scholar 

  • Lindvall, O., and Björklund, A., 1974, The organization of the ascending catecholamine neuron systems in the rat brain, Acta Physiol. scand., suppl. 412:1.

    Google Scholar 

  • Mason, S.T., and Iversen, S.D., 1979, Theories of the dorsal bundle extinction effect, Brain Res. Rev., 1:107.

    Article  Google Scholar 

  • McNaughton, N., and Mason, S.T., 1980, The neurophysiology and neuropharmacology of the dorsal ascending noradrenergic bundle: a review, Progr. Neurobiol., 14:157.

    Article  Google Scholar 

  • Moore, R.Y., and Bloom, F.E., 1979, Central catecholamine neuron systems: Anatomy and physiology of the norepinephrine and epinephrine systems, Ann. Rev. Neurosci., 2:113.

    Article  Google Scholar 

  • Owen, S.R., Boarder, M.R., Gray, J.A., and Fillenz, M., 1982, Acquisition and extinction of continuously and partially reinforced running in rats with lesions of the dorsal noradrenergic bundle, Behav. Brain Res., 5:11.

    Article  Google Scholar 

  • Pfister, H.P., 1979, The glucocorticosterone response to novelty as a psychological stressor, Physiol. Behav., 23:649.

    Article  Google Scholar 

  • Pisa, M., and Fibiger, H.C., 1980, Noradrenaline and discrimination learning: Failure to support the attentional hypothesis, Soc. Neurosci. Abstr., 6:724.

    Google Scholar 

  • Roberts, D.C.S., Price, M.T.C., and Fibiger, H.C., 1976, The dorsal tegmental noradrenergic projection: an analysis of its role in maze learning, J. comp. physiol. Psychol., 90:363.

    Article  Google Scholar 

  • Segal, M., and Bloom, F.E., 1976, The action of norepinephrine in the rat hippocampus. IV. The effect of locus coeruleus stimulation on evoked hippocampal unit activity, Brain Res., 107:513.

    Google Scholar 

  • Sessions, C.R., Kant, G.J., and Koob, G.F., 1976, Locus coeruleus lesions and learning in the rat, Physiol. Behav., 17:853.

    Article  Google Scholar 

  • Stone, E.A., 1975, Stress and catecholamine, in: “Catecholamine and Behavior”, A.J. Friedhoff, ed., Vol.2, Plenum Press, N.Y.

    Google Scholar 

  • Tsuda, A., Tanaka, M., Kohno, Y., Nishikawa, T., Iimori, K., Nakagawa, R., Hoaki, Y., Ida, Y., and Nagasaki, N., 1982, Marked enhancement of noradrenaline turnover in extensive brain regions after activity stress in rats, Physiol. Behav., 29:337.

    Article  Google Scholar 

  • Velley, L., and Cardo, B., 1977, A long-term effect of an early stimulation of the lateral hypothalamus on the acquisition and extinction of a food reinforced operant conditioning in the rat, Neurosci. Lett., 5:221.

    Article  Google Scholar 

  • Velley, L., and Cardo, B., 1979, Long-term improvement of learning after early electrical stimulation of some central nervous structures: is the effect structure and age-dependent ? Brain Res. Bull., 4:459.

    Article  Google Scholar 

  • Velley, L., Cardo, B., and Bockaert, J., 1981a, Modulation of rat brain adrenoceptor populations four weeks after stimulation of the nucleus locus coeruleus, Psychopharmacology, 74:226.

    Article  Google Scholar 

  • Velley, L., Chassaing, J.M., and Cardo, B., 1981b, Learning improvement of appetitively or aversively reinforced light-dark discrimination and reversal four weeks after electrical stimulation of the lateral hypothalamus of the rat, Brain Res. Bull., 6:377.

    Article  Google Scholar 

  • Velley, L., Kempf, E., and Cardo, B., 1982, Locomotor activity of rats after stimulation of the nucleus locus coeruleus region or after lesion of the dorsal noradrenergic bundle, Psychopharmacology, 78:239

    Article  Google Scholar 

  • Velley, L.,1983, Rôle des systèmes aminergiques centraux dans la maîtrise des conduites acquises. Thèse d’Etat, Université de Bordeaux I.

    Google Scholar 

  • Velley, L., Nassif, S., Kempf, E., and Cardo, B., 1983, Enhancement of learning four weeks after stimulation of the nucleus locus coeruleus in the rat: Differential effects of dorsal noradrenergic bundle lesion and lesion of the locus coeruleus proper, Brain Res., 265:273

    Article  Google Scholar 

  • Weiss, J.M., Goodman, P.A., Losito, B.G., Corrigan, S., Charry, J.M., and Bailey, W.H., 1981, Behavioral depression produced by an un-controlable stressor: Relationship to norepinephrine, dopamine and serotonin levels in various regions of the rat brain, Brain Res. Rev., 3:167.

    Article  Google Scholar 

  • Woodward, D.J., Moises, H.C, Waterhouse, B.D., Hoffer, B.J., and Freedman R., 1979, Modulatory actions of norepinephrine in the central nervous system, Fed. Proc., 38:2109.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Plenum Press, New York

About this chapter

Cite this chapter

Velley, L., Kempf, E., Velly, J., Cardo, B. (1985). Role of the Locus Coeruleus System in Behavioral Plasticity. In: Will, B.E., Schmitt, P., Dalrymple-Alford, J.C. (eds) Brain Plasticity, Learning, and Memory. Advances in Behavioral Biology, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5003-3_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5003-3_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5005-7

  • Online ISBN: 978-1-4684-5003-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics