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Phosphatidylcholine Transfer Protein: Model for Lipid-Protein Interactions and Probe for Membrane Research

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Recent Advances in Biological Membrane Studies

Part of the book series: NATO ASI Series ((NSSA,volume 91))

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Abstract

Nature has provided for proteins that enable the constituent lipids to leave the physical constraints of the membrane structure. By their mode of action, these proteins facilitate in vitro the transfer of monomer lipid molecules between membranes. Lipid transferring proteins have been identified for phospholipids (for reviews, see Refs. 1 and 2), cholesterol3 and glycolipids4, 5. The physiological role of these proteins is still a matter of conjecture. In this regard, it is of interest that the transfer of ganglioside GM2 between membranes is facilitated by a specific protein, whose actual function is to present this ganglioside to hexosaminidase A as a water-soluble activator/lipid complex6.

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Authors and Affiliations

  1. Laboratory of Biochemistry, State University of Utrecht, Utrecht, The Netherlands

    Karel W. A. Wirtz, Jos A. F. Op den Kamp, Ben Roelofsen & L. L. M. van Deenen

  2. Department of Biochemistry, Agricultural University, Wageningen, The Netherlands

    Anton J. W. G. Visser

Authors
  1. Karel W. A. Wirtz
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  2. Anton J. W. G. Visser
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  3. Jos A. F. Op den Kamp
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  4. Ben Roelofsen
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  5. L. L. M. van Deenen
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Editors and Affiliations

  1. University of California, Berkeley, Berkeley, California, USA

    Lester Packer

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© 1985 Plenum Press, New York

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Wirtz, K.W.A., Visser, A.J.W.G., Op den Kamp, J.A.F., Roelofsen, B., van Deenen, L.L.M. (1985). Phosphatidylcholine Transfer Protein: Model for Lipid-Protein Interactions and Probe for Membrane Research. In: Packer, L. (eds) Recent Advances in Biological Membrane Studies. NATO ASI Series, vol 91. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4979-2_3

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  • DOI: https://doi.org/10.1007/978-1-4684-4979-2_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4981-5

  • Online ISBN: 978-1-4684-4979-2

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