Advertisement

Immune Complexes in Patients Bearing Solid Tumors

  • Didier Cupissol
  • Christian Thierry
  • Bernard C. Serrou
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 15)

Abstract

An immune complex is an immunological association of an antigen with its antibody. The nature of this complex is determined by the characteristics of the two constituents. The immunoglobulins involved in circulating immune complexes (CIC) undergo stereochemical transformations to render them incapable of reacting with diverse elements of the immune system as well as with cells responsible for inflammatory response, e. g., platelets, histiocytes, and erythrocytes. However, as with other immune phenomena, the formation and role of CIC is subject to a control mechanism determined by the nature of the antigen itself. Numerous authors have reported that insoluble CIC levels were frequently elevated in cancer patients. The prognostic value of these variations has been discussed (Amlot et al., 1976, 1978; Benveniste et al., 1972; Brandis et al., 1978; Camussi et al., 1977; Carpentier et al., 1977; Cochrane, 1968; Gauci et al, 1978b,c; Jose and Seshadri, 1974; Silberberg-Sinakin et al., 1977).

Keywords

Immune Complex Platelet Activate Factor Primary Hepatoma ADCC Activity Mune Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Amlot, P. L., Slaney, J. M., and Williams, B. D., 1976, Circulating immune complexes and symptoms in Hodgkin’s disease, Lancet 1: 449.PubMedCrossRefGoogle Scholar
  2. Amlot, P. L., Pussel, B., Slaney, M. J., and Williams, B. D., 1978, Correlation between immune complexes and prognostic factors in Hodgkin’s disease, Clin. Exp. Immunol. 31: 166.PubMedGoogle Scholar
  3. Benveniste, J., Henson, P. M., and Cochrane, C. G., 1972, Leukocyte-dependent histamine release from rabbit platelets: The role of IgE, basophils and a platelet activating factor, J. Exp. Med. 136: 1356.PubMedCrossRefGoogle Scholar
  4. Brandeis, W. E., Helson, L., Wang, Y., Good, R. A., and Day, N. K., 1978, Circulating immune complexes in sera of children with neuroblastoma: Correlation with stage of disease, J. Clin. Invest. 62: 1201.PubMedCrossRefGoogle Scholar
  5. Camussi, G., Mencia-Huerta, J. M., and Benveniste, J., 1977, Release of platelet activating factor and histamine. I. Effect of immune complexes, complement and neutrophils on human and rabbit mastocytes and basophils, Immunology 33: 523.PubMedGoogle Scholar
  6. Carpentier, N. A., Lange, G. T., Fiere, D. M., Fournie, G. J., Lambert, P. H., and Miescher, P. A., 1977, Clinical relevance of circulating immune complexes in human leukemia: Association in acute leukemia of the presence of immune complexes with unfavourable prognosis, J. Clin. Invest. 60: 874.PubMedCrossRefGoogle Scholar
  7. Carr, I., and Underwood, J. C. E., 1974, The ultrastructure of the local cellular reaction to neoplasia, Int. Rev. Cytol. 37: 329.PubMedCrossRefGoogle Scholar
  8. Cochrane, C. G., 1968, Immunologic tissue injury mediated by neutrophilic leukocytes, Adv. Immunol. 9: 97.PubMedCrossRefGoogle Scholar
  9. Gauci, L., Reme, T., Ursule, E., and Serrou, B., 1978a, Caracterisation immuno-néphélométrique des complexes immuns chez les cancéreux, Biol. Prosp. IV Colloq. Pont. à Mousson 236: 678.Google Scholar
  10. Gauci, L., Ursule, E., and Serrou, B., 1978b, Circulating immune complexes in malignant melanoma, in: Cutaneous Immunopathology ( J. Thivolet and D. Schmitt, eds.), p. 357, INSERM, Paris.Google Scholar
  11. Gauci, L., Ursule, E., Pujol, H., and Serrou, B., 1978c, Clinical implications of elevated levels of circulating immune complexes in patients with malignant melanoma, in: Protides of the Biological Fluids ( H. Peeters, ed.), Vol. 26, p. 349, Pergamon Press, Oxford.Google Scholar
  12. Heier, H. E., Carpentier, N., Lange, G., Lambert, P. H., and Godai, T., 1977, Circulating immune complexes in patients with malignant lymphomas and solid tumors, Int. J. Cancer 20: 887.PubMedCrossRefGoogle Scholar
  13. Heimer, R., and Klein, G., 1976, Circulating immune complexes in sera of patients with Burkitt’s lymphoma and nasopharyngeal carcinoma, Int. J. Cancer 18: 310.PubMedCrossRefGoogle Scholar
  14. Jose, D. G., and Seshadri, R., 1974, Circulating immune complexes in human neuroblastoma: Direct assay and role in blocking specific cellular immunity, Int. J. Cancer 13: 824.PubMedCrossRefGoogle Scholar
  15. Silberberg-Sinakin, I., Fedorka, M. E., Baer, R. L., Rosenthal, S. A., Berezowsky, V., and Thorbecke, G. J., 1977, Langerhans cells: Target cells in immune complex reactions, Cell Immunol 32: 400.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Didier Cupissol
    • 1
    • 2
  • Christian Thierry
    • 1
    • 2
  • Bernard C. Serrou
    • 1
    • 2
  1. 1.Department of Chemo-ImmunotherapyERA-CNRS No. 844, Centre Paul LamarqueMontpellier CedexFrance
  2. 2.Laboratory of Tumor Immunopharmacology INSERM U-236ERA-CNRS No. 844, Centre Paul LamarqueMontpellier CedexFrance

Personalised recommendations