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Erythrocyte-Mediated Metabolic Activation Detected by SCE

  • Chapter
Sister Chromatid Exchanges

Abstract

Microsomal metabolism has proved to be essential for the acti vation of many chemical carcinogens. For this reason in vitro mutagenicity tests include a metabolic activation system. As a rule, the metabolizing mixtures are prepared from the postmitochondrial fraction of rodent liver. While it is generally accepted that the liver is the primary organ of xenobiotic metabolism for a number of chemicals, it is also known that other tissues can contribute both to the activating and inactivating reactions. The ratio between activation and inactivation may be an important parameter in determining the target tissue of a precarcinogen. However, S-9 mixes from sources other than the liver have only seldom been used in mutagenicity tests.

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Author information

Authors and Affiliations

  1. Institute of Occupational Health, Haartmaninkatu 1, SF-00290, Helsinki 29, Finland

    Hannu Norppa

  2. Istituto di Ricerche Farmacologiche “Mario Negri,”, Via Eritrea 62, 20157, Milan, Italy

    Francesco Tursi

Authors
  1. Hannu Norppa
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  2. Francesco Tursi
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Editor information

Editors and Affiliations

  1. Medical Department, Brookhaven National Laboratory, Upton, New York, 11973, USA

    Raymond R. Tice

  2. Council for Research Planning in Biological Sciences, Inc, 1717 Massachusetts Avenue, NW, Washington, DC, 20036-2077, USA

    Alexander Hollaender

  3. Department of Clinical Genetics, Karolinska Hospital, 10401, Stockholm, Sweden

    Bo Lambert

  4. Department of Public Health, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan

    Kanehisa Morimoto

  5. Council for Research Planning in Biological Sciences, Inc, Washington, D.C., USA

    Claire M. Wilson

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© 1984 Plenum Press, New York

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Norppa, H., Tursi, F. (1984). Erythrocyte-Mediated Metabolic Activation Detected by SCE. In: Tice, R.R., Hollaender, A., Lambert, B., Morimoto, K., Wilson, C.M. (eds) Sister Chromatid Exchanges. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4892-4_4

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  • DOI: https://doi.org/10.1007/978-1-4684-4892-4_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4894-8

  • Online ISBN: 978-1-4684-4892-4

  • eBook Packages: Springer Book Archive

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