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Effect of iron and hemoproteins on hydrogen peroxide-supported styrene oxidation to styrene oxide

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Summary

Fe2+, Fe3+ and their complexes with EDTA and hemin, methemalbumin and methemoglobin were active catalyzers of H2O2 supported styrene oxidation to styrene oxide. Methemoglobin was the most active compound; its peroxidative activity was comparable to that of cytochrome P-450 in liver microsomes of phenobarbital-treated rats. Cumene hydroperoxide supported styrene oxidation with methemoglobin and microsomal hemoproteins and was found to be more efficient than H2O2.

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Authors and Affiliations

  1. Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea 62, I-20157, Milan, Italy

    Lavinia Cantoni, D. Blezza & G. Belvedere

Authors
  1. Lavinia Cantoni
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  2. D. Blezza
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  3. G. Belvedere
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Additional information

This work was supported by C.N.R. (National Research Council) contract No. 79.03197.04.

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Cantoni, L., Blezza, D. & Belvedere, G. Effect of iron and hemoproteins on hydrogen peroxide-supported styrene oxidation to styrene oxide. Experientia 38, 1192–1194 (1982). https://doi.org/10.1007/BF01959735

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  • DOI: https://doi.org/10.1007/BF01959735

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