Abstract
Although some progress has been made in clarifying the molecular basis underlying neoplastic transformation, antineoplastic treatment is still based on the effort toward the removal of all neoplastic cells. In this respect, the most important requirement for the effectiveness of treatment is the precocious diagnosis, possibly in the preclinical period. Clinical, radiological and endoscopic examinations are often poorly sensitive and in some cases invasive and dangerous, thus efforts are focused to obtain a precocious tumor detection by biochemical or biological assays.
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References
Adams W. S., Davis F. and Nakatani M., 1960, Purine and pyrimidine excretion in normal and leukemic subjects, Am. J. Med. 28: 726.
Adler M. and Gutman A. B., 1959, Uridine isomer (5-ribosyluracil) in human urine, Science 130: 862.
Arena F., Ciliberto G., Ciampi S., and Cortese R., 1978, Purification of pseudouridylate synthetase I from Salmonella typhimurium, Nucleic Acid Res. 5: 4523.
Borek E., Baliga B. S., Gehrke C.W., Kuo K. C., Belman S., Troll W., Waalkes T. P., 1977, High turnover rate of transfer RNA in tumor tissue, Cancer Res. 37: 3362.
Brand R. C., Klootwijk J., Siburn C. P. and Planta R. J., 1979, Pseudouridylation of yeast ribosomal precursor RNA, Nucleic Acids Res. 7: 121.
Busch H., Reddy R., Rothblum L. and Choi Y. C., 1982, SnRNAs, snRNPs, and RNA processing, Ann. Rev. Biochem. 51: 617.
Chambers R. W., The chemistry of pseudouridine, 1966, Prog. Nucleic Acid Res. Mol. Biol. 5: 349.
Chang S.Y., Lakings D. B., Zumwalt R. W., Gehrke C. W. and Waalkes T. P., 1974, Quantitative determination of methylated nucleosides and pseudouridine in urine by gas-liquid chromatography, J. Lab. Clin. Clin. Med. 83: 816.
Cimino F., Costanzo F., Russo T., Colonna A., Esposito F., Salvatore F., 1982, Modified nucleosides from transfer ribonucleic acid as tumor markers, in:“The Biochemistry of S-Adenosylmethionine and related compounds”, E. Usdin, R. T. Borchardt, C.R. Creveling, eds., MacMillan, London.
Colonna A. and Kerr S. J., 1980, The nucleus as the site of tRNA methylation, J. Cell. Physiol. 103: 29.
Colonna A., Duilio A., Russo T., Salvatore F., and Cimino F., 1983a, tRNA pseudouridine synthase activity in malignant cells. Abstracts of 15th F.E.B.S. Meeting, Bruxelles, p. 243.
Colonna A., Russo T., Esposito F., Salvatore F., Cimino F.,1983b Determination of pseudouridine and other nucleosides in human blood serum by high performance liquid chromatography, Anal. Biochem. 130: 19.
Cooper I. A., Wray G. R. and Murphy T. L., 1977, Urinary excretion patterns of tRNA degradation products: a marker of Hodgkin’s cell metabolism? Europ. J. Cancer 13: 1309.
Cortese R., Kammen H. O., Spengler S. J., and Ames B. N., 1974a, Biosynthesis of pseudouridine transfer ribonucleic acid, J. Biol. Chem. 249: 1103.
Cortese R., Landsberg R., Von der Haar R. A., Umbarger H. E. and Ames B. N., 1974b, Pleiotropy of His T mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucinevaline operon, Proc. Natl. Acad. Sci. U.S.A., 71: 1857.
Esposito F., Ammendola R., Russo T., and Cimino F., 1983, Abstract of 29th Meeting of S.I.B., Saint Vincent, Italy, p. 509.
Fujimura S. and Shimizu M., 1977, Enhanced activity of tRNA pseudouridine synthetase in Yoshida ascites sarcoma. Biochim. Biophys. Res. Commun. 79: 763.
Gauss D.H. and Sprinzl, 1983, Compilation of tRNA sequences, Nucleic Acid Res., 11: r1.
Gehrke C. W., Kuo K. C., Davis G. E., Suits R. D., Waalkes T. P.,E. Borek, 1978, Quantitative high-performance liquid chromatography of nucleoside in biological materials. J. Chromatogr. 150: 455.
Gehrke C. W., Kuo K. C., Waalkes T. P., Borek E., 1979, Pattern of urinary excretion of modified nucleosides, Cancer Res. 39: 1150.
Green C. J., Kammen H. O., and Penhoet E. E., 1982, Purification and properties of a mammalian tRNA pseudouridine synthase, J. Biol. Chem. 257: 3045.
Gross L., 1970, “Oncogenic viruses”, Pergamon Press, London.
Harada F., Sawyer R. C., and Dahlberg J. E., 1975, A primer ribonucleic acid for initiation of in vitro Rous sarcoma virus deoxyribonucleic acid synthesis, J. Biol. Chem. 2500: 3483.
Harada F., Peters G. G., and Dahlberg J. E., 1979, The primer tRNA for Moloney murine leukemia virus DNA synthesis, J. Biol. Chem. 254: 10979.
Heldman D. A., Grever M. R., Trewyn R. W., 1983, Differential excretion of modified nucleosides in adult acute leukemia, Blood 61: 291.
Hogan A., Creuss-Callaghan A. and Fennelly J. J., 1970, Studies of pseudouridine change in chronic lymphatic leukemia during therapy, Ir. J. Med. Sci. 3: 505.
Hughes D. G. and Maden B. E. H., 1978, The pseudouridine contents of the ribosomal ribonucleic acids of three vertebrate species, Biochem. J. 171: 781.
Kuo K. C., Gehrke C. W., Mc Cune R. A., Waalkes T. P. and Borek E.,1978, Rapid, quantitative high-performance liquid column chromatography of pseudouridine, 145: 383.
Levine L. Waalkes T. P., and Stolbach L., 1975, Serum levels of N,N -dimethylguanosine and pseudouridine as determined by radioimmunoassay for patients with malignancy, J. Natl. Cancer Inst. 54:341.
Matsushita T., and Davis F. F., 1971, Studies on pseudouridylic acid synthetase from various sources. Biochim. Biophys. Acta 238: 165.
Melton D. A., De Robertis E. M., and Cortese R., 1980, Order and intracellular location of the events involved in the maturation of the spliced RNA, Nature 284: 143.
Ming Chu T., 1982, “Biochemical markers for cancer”, Marcel Dekker Inc., New York and Berlin.
Park R. W., Holland J. F. and Jenkins R., 1962, Urinary purines in leukemia, Cancer Res. 22: 469.
Pinkard K. J., Cooper I. A., Motterman R. and Turner C. N., 1972, Purine and pyrimidine excretion in Hodgkin’s disease, J. Natl. Cancer Inst. 49: 27.
Randerath K., Yu C. T. and Randerath E., 1972, Base analysis of ribopolynucleotides by chemical tritium labeling: a methodological study with model nucleosides and purified tRNA species, Anal. Biochem. 48: 172.
Russo T., Bridges S., Gurgo C., Salvatore F., and Cimino F., 1983a, Determination of pseudouridine present in tRNA and in acid soluble extract of thymic murine lymphoma. Abstracts of 15th F.E.B.S. Meeting, Bruxelles, p. 313.
Russo T. and Cimino F., 1983b, High performance liquid chromatography analysis of nucleoside composition of tRNA. Abstracts of 3rd International Symposium on HPLC of Proteins, Peptides and polynucleotides, p. 24.
Russo T., Colonna A., Salvatore F., Cimino F., Bridges S., and Gurgo C., 1983c, Serum pseudouridine as a biochemical marker in the development of AKR mouse lymphoma. Cancer Res.,in press.
Salvatore F., Colonna A., Costanzo F., Russo T., Esposito F., and F. Cimino, 1983a, Modified nucleosides in body fluids of tumor-bearing patients, Recent Results Cancer Res. 84: 360.
Salvatore F., Russo T., Colonna A., Cimino L., Mazzacca G., and Cimino F., 1983b, Pseudouridine determination in blood serum as tumor marker, Cancer Detec. Prey. 6: in press.
Shimizu M., and Fushimura S., 1978, Studies on the abnormal excretion of pyrimidine nucleosides in the urine of Yoshida ascites sarcoma-bearing rats, Biochim. Biophys, Acta 517: 277.
Speer J., Gehrke C. W., Kuo K. C., Waalkes T. P., Borek E., 1979, tRNA breakdown products as markers for cancer, Cancer 44: 2120.
Thomale J., and Nass G., 1982, Elevated urinary excretion of RNA catabolites as an early signal of tumor development in mice. Cancer Letters 15: 149.
Tormey D. C., Waalkes T. P., Gehrke C. W., 1980, Biological markers in breas 9rcinoma. Clinical correlation with pseudouridine, N,N -dimethylguanosine and 1-methylinosine, J. Surg. Oncol. 14: 267.
Trewyn R. W., Glaser R., Kelly D. R., Jakson D. G., Graham W. P., and Speicher C. E., 1982, Elevated nucleoside excretion by patients with nasopharyngeal carcinoma, Cancer 49: 2513.
Waalkes T. P., Gehrke C. W., Zumwalt R. W., Chang S. Y., Lakings D.B., Tormey D. C., Ahmann D. L., Moertel C. G., 1975, The urinary excretion of nucleosides of ribonucleic acid by patients with advanced cancer, Cancer 36: 390.
Waalkes T. P., Abeloff M. D., Ettinger D. S., Woo K. B., Gehrke C. W., Kuo K. C., Borek E., 1982, Biological markers and small cell carcinoma of the lung. A clinical evaluation of urinary ribonucleosides, Cancer 50: 2457.
Weissman B., Bromberg P. A. and Guttman A. B., 1957, The purine bases of human urine. Separation and identification. J. Biol. Chem. 224: 407.
Weissman S. M., Lewis M. and Karon M., 1963, Pseudouridine metabolism. Excretion of pseudouridine and other nitrogenous metabolites in chronic leukemia, Blood 22: 657.
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Cimino, F., Russo, T., Colonna, A., Salvatore, F. (1984). Pseudouridine: A Biochemical Marker for Cancer. In: Aaronson, S.A., Frati, L., Verna, R. (eds) Genetic and Phenotypic Markers of Tumors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4856-6_3
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DOI: https://doi.org/10.1007/978-1-4684-4856-6_3
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