Summary
Pseudouridine excretion has been measured in a group of patients with chronic lymphatic leukaemia using a modification of methods so far described. All had elevated levels initially, which returned to normal after treatment, though there was a transient rise in levels as the white cell count reduced. This suggests an increased turnover of t-RNA in these patients, but the reason for this is not known at present.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kruger, M., and Salimon, G. (1898). Zeschr. f. Physiol. Chem. 24: 364.
Horrigan, D. L. (1954). J. Clin. Invest. 33: 301–5.
Davis, F. F., and Allen, F. W. (1957). J. Biol. Chem. 227: 907.
Adler, M., and Gutman, A. B. (1959). Science, 130: 862–3.
Adams, W. S., Davis, F., and Nakatami, M. (1960). Amer. J. Med. 28: 726–34.
Weissman, S., Eisen, A.Z., and Karon, M. (1962). J. Lab. Clin. Med. 59: 852.
Park, R. W., Holland, F. J., and Jenkins, A. (1962). Cancer Res. 22: 469.
Bollard, B. M., Culpan, R. H. (1960). J. Ment. Scir. 106: 1250.
Weissman, S. M. Blood, XXII 6. (1963).
Heirweigh K. P. M., Ramboer, C., Groote, J. de (1967). Amer. J. Med. 42: 913.
Bosnes, R. W., Taussky, H. H. (1945). J. Biol. Chem. 158: 581.
Archibald, R. M. (1944). J. Biol. Chem. 156: 121.
Little, J. R. (1962). Blood, 19: 236.
Froholm, L. O. (1967). Int. J. Rad. Biol. 12.1. 35–49.
Author information
Authors and Affiliations
Additional information
This work has been carried out with the support of the Irish Cancer Society.
Rights and permissions
About this article
Cite this article
Hogan, A., Creuss-Callaghan, A. & Fennelly, J.J. Studies of pseudouridine changes in chronic lymphatic leukaemia during therapy. I. J. Med. Sc. 3, 505–511 (1970). https://doi.org/10.1007/BF02958969
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02958969