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Acetylcholine Receptor

Some Methods Developed to Study a Membrane-Bound Regulatory Protein

  • Chapter
Cell Membranes

Abstract

The acetylcholine receptor protein, found in the synaptic membranes of many nerve cells, at the neuromuscular junction, and in the electric organ of several fish, plays a key role in the transmission of nerve impulses (Katz, 1969; Nachmansohn, 1973; Nachmansohn and Neumann, 1975) and is being studied in many ways in many laboratories (Karlin, 1980; Changeux, 1981; Conti-Tronconi and Raftery, 1982). The electroplax of various fish (E. electricus and Torpedo spp.) has been used extensively in studies of the receptor protein. Here we will concentrate on methods developed in this laboratory to investigate the receptor and membrane-bound proteins in general. For studies of other membrane-bound proteins and the methods developed to study them, the reader is referred to Racker (1970), Kaback (1970), and Dewey and Hammes (1981).

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  1. Section of Biochemistry, Molecular and Cell Biology, Division of Biological Sciences, Cornell University, Ithaca, New York, 14853, USA

    Susan E. Coombs & George P. Hess

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  1. Washington University School of Medicine, St. Louis, Missouri, USA

    Elliot Elson , William Frazier  & Luis Glaser ,  & 

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Coombs, S.E., Hess, G.P. (1984). Acetylcholine Receptor. In: Elson, E., Frazier, W., Glaser, L. (eds) Cell Membranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4823-8_8

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