Cell Membranes pp 295-364 | Cite as

Acetylcholine Receptor

Some Methods Developed to Study a Membrane-Bound Regulatory Protein
  • Susan E. Coombs
  • George P. Hess


The acetylcholine receptor protein, found in the synaptic membranes of many nerve cells, at the neuromuscular junction, and in the electric organ of several fish, plays a key role in the transmission of nerve impulses (Katz, 1969; Nachmansohn, 1973; Nachmansohn and Neumann, 1975) and is being studied in many ways in many laboratories (Karlin, 1980; Changeux, 1981; Conti-Tronconi and Raftery, 1982). The electroplax of various fish (E. electricus and Torpedo spp.) has been used extensively in studies of the receptor protein. Here we will concentrate on methods developed in this laboratory to investigate the receptor and membrane-bound proteins in general. For studies of other membrane-bound proteins and the methods developed to study them, the reader is referred to Racker (1970), Kaback (1970), and Dewey and Hammes (1981).


Acetylcholine Receptor Membrane Preparation Functional Receptor Unspecific Binding Receptor Inactivation 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Susan E. Coombs
    • 1
  • George P. Hess
    • 1
  1. 1.Section of Biochemistry, Molecular and Cell Biology, Division of Biological SciencesCornell UniversityIthacaUSA

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