Genetic Origin, Immunobiology, and Gonadotropin Expression in Trophoblast and Nontrophoblast Neoplasms

  • Roland A. Pattillo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 176)


A sequence of chronologic steps leading to the identification of exclusively paternal chromosomes in most hydatidiform moles has been developed. It had long been recognized that most moles were chromatin-positive at the nuclear margin. This was confusing, however, since one would ordinarily expect a 50:50 ratio of chromatin-positive to chromatin-negative moles. The initial large study by Baggish and Woodruff (1) on moles treated in Singapore revealed that all 90 moles studied showed well-defined heterochromatin bodies.


Genetic Origin Histocompatibility Antigen Hydatidiform Mole Mixed Lymphocyte Culture Trophoblastic Tumor 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Roland A. Pattillo
    • 1
  1. 1.Department of Gynecology and ObstetricsMedical College of WisconsinMilwaukeeUSA

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