Human Trophoblast Neoplasms

  • Roland A. Pattillo
  • Robert O. Hussa

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 176)

Table of contents

  1. Front Matter
    Pages i-x
  2. Pregnancy and Neoplasia

  3. Immunology, Gestation, and Neoplasia

    1. Front Matter
      Pages 51-52
    2. Ryoki Ohkawa, Kimiyasu Ohkawa, Norio Tosaka, Toshikatsu Ohhashi, Akira Hatano, Tsutomu Ohkawa
      Pages 111-125
    3. Tim Parmley
      Pages 127-132
  4. Genetic Origin of Trophoblast Neoplasms

    1. Front Matter
      Pages 133-133
    2. Sylvia D. Lawler
      Pages 147-161
  5. Epidemiologic Aspects of Trophoblastic Neoplasms

    1. Front Matter
      Pages 163-163
    2. M. Farid Aziz, Nugroho Kampono, Endy Muhardin Moegni, Sjahrul Sjamsuddin, Budianto Barnas, Ratna Suprapti Samil
      Pages 165-175
    3. Akin Agboola, O. O. Abudu
      Pages 187-195
  6. Human Chorionic Gonadotropin

    1. Front Matter
      Pages 197-197
    2. R. E. Canfield, S. Birken, P. Ehrlich, G. Armstrong
      Pages 199-215
    3. Robert Hussa, Laurence A. Cole
      Pages 217-243
    4. Laurence A. Cole, Robert O. Hussa
      Pages 245-270

About this book


This book addresses neoplasms of the human trophoblast. The scant literature available on the epidemiology of trophoblast neoplasms suggests that they are as much as ten times more common in Africa, Asia, India, and much of the developing world than in Western countries. The stimulus for the book evolved out of a common interest to combine Western technology with the clinical experience in the developing world in a common pursuit of the study and eradication of trophoblast neoplasia. There is substantial evidence to contend that gene derepression as seen in trophoblastic disease may be a universal prerequisite to neoplastic transformation in general. The recent discovery that the tumor markers, human chorionic gonadotropin (hCG) or its subunits, are identifiable in over 90 percent of all extracted neoplasms suggests a critical role for this common denominator of gene derepression in neoplasia. This gene derepression concept in reproductive biology and neoplasia spans many of the basic parameters of human cell replication as related to endocrinology, immunology, biochemistry, electrophysiol­ ogy, genetics, and pharmacology. The International Society for the Study of Trophoblastic Disease focuses on the global aspects of trophoblast neoplasms. These global aspects include epidemiology and etiology of the disease, regional variations in treatment of trophoblastic neoplasms, and potential ways to adapt and apply Western technology to effective use in developing countries. It was this perspective that formed the basis for the First World Congress on Trophoblast Neoplasms, which convened in Nairobi in October, 1982.


cell endocrinology epidemiology genetics pharmacology tumor

Editors and affiliations

  • Roland A. Pattillo
    • 1
  • Robert O. Hussa
    • 1
  1. 1.Department of Gynecology and ObstetricsThe Medical College of WisconsinMilwaukeeUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1984
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-4813-9
  • Online ISBN 978-1-4684-4811-5
  • Series Print ISSN 0065-2598
  • About this book