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Interaction of Enkephalin with Opioid Receptors of Brain Membranes: Regulation by Essential Transition Metals, Guanine Nucleotides and Temperature

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Neurotransmitter Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 175))

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Abstract

Guanine nucleotides [guanosine-5′-triphosphate: GTP, and guanylyl-5′-imidophosphate: Gpp(NH)p] play an important role in regulating β-noradrenergic (1), α-noradrenergic (2), dopamine (3) and other neurotransmitter receptors. Guanine nucleotides also decrease the receptor binding of tritiated opiate agonists but not that of the antagonists (1,4–6).

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Author information

Authors and Affiliations

  1. Institute for Neurobiology, Okayama University Medical School, Okayama, Japan

    Norio Ogawa, Sachiko Mizuno & Akitane Mori

Authors
  1. Norio Ogawa
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  2. Sachiko Mizuno
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  3. Akitane Mori
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Editor information

Editors and Affiliations

  1. Third Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima 734, Japan

    Shozo Kito M.D., Ph.D.

  2. Department of Pharmacology Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima 734, Japan

    Tomio Segawa Ph.D.

  3. Department of Pharmacology, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyoku Kyoto 602, Japan

    Kinya Kuriyama M.D.

  4. Departments of Pharmacology, Biochemistry, Psychiatry and the Arizona Research Laboratories, University of Arizona Health Sciences Center, 85724, Tucson, Arizona, USA

    Henry I. Yamamura Ph.D.

  5. Department of Pharmacology, University of California, Los Angeles School of Medicine, 90024, Los Angeles, California, USA

    Richard W. Olsen Ph.D.

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© 1984 Plenum Press, New York

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Ogawa, N., Mizuno, S., Mori, A. (1984). Interaction of Enkephalin with Opioid Receptors of Brain Membranes: Regulation by Essential Transition Metals, Guanine Nucleotides and Temperature. In: Kito, S., Segawa, T., Kuriyama, K., Yamamura, H.I., Olsen, R.W. (eds) Neurotransmitter Receptors. Advances in Experimental Medicine and Biology, vol 175. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-4805-4_13

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  • DOI: https://doi.org/10.1007/978-1-4684-4805-4_13

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-4807-8

  • Online ISBN: 978-1-4684-4805-4

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