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Differential effects of some transition metal cations on the binding of β-carboline-3-carboxylate and diazepam

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Abstract

The interaction of benzodiazepines and β-carbolines with metal cations was investigated. Among numerous transition metal cations, only three, Co2+, Ni2+ and Zn2+, specifically inhibited the binding of [3H]β-carboline-3-carboxylate ethyl ester (β-CCE). The effects of these cations on [3H]β-CCE binding were exactly opposite to those on [3H]diazepam binding. The effects of these cations was not dependent on lipid peroxidation. The differential effect of these cations may reflect a general difference in the way agonists and antagonists bind to the benzodiazepine receptor.

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Authors and Affiliations

  1. Department of Neurochemistry Institute for Neurobiology, Okayama University Medical School, 2-5-1, Shikata Cho, 700, Okayama, Japan

    S. Mizuno, N. Ogawa & A. Mori

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  1. S. Mizuno
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  2. N. Ogawa
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  3. A. Mori
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Mizuno, S., Ogawa, N. & Mori, A. Differential effects of some transition metal cations on the binding of β-carboline-3-carboxylate and diazepam. Neurochem Res 8, 873–880 (1983). https://doi.org/10.1007/BF00964548

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  • DOI: https://doi.org/10.1007/BF00964548

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