The Genes Encoding Anti-NP Antibodies in Inbred Strains of Mice

  • Alfred L. M. Bothwell


The phenomenon of recurrent idiotypes has provided access to immunological interactions of various kinds. By definition, the antigenic structures which specify the variable regions of heavy and light chains of antibodies form the idiotypic determinants. They must be generated by B cells yet are apparently recognized and perhaps mimicked by T cells. The expression of idiotypes on B cells poses many questions. Most important to our investigation is determining the nature of the mechanisms causing the selection for the generation of an idiotype. Do the idiotypic structures form a focal point for lymphocyte interactions or are they primarily the consequence of other types of biological regulation?


Somatic Mutation EcoRI Fragment Contact Residue Somatic Variant Idiotypic Determinant 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Alfred L. M. Bothwell
    • 1
  1. 1.Department of Pathology, Division of Immunology, and The Howard Hughes Medical InstituteYale University School of MedicineNew HavenUSA

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