The Biology of Idiotypes

  • Mark I. Greene
  • Alfred Nisonoff

Table of contents

  1. Front Matter
    Pages i-xv
  2. Molecular Genetic Aspects of Idiotypes

    1. Front Matter
      Pages 1-1
    2. Stanley J. Korsmeyer, Ajay Bakhshi, Andrew Arnold, Katherine A. Siminovitch, Thomas A. Waldmann
      Pages 75-95
    3. Michel Fougereau, José Rocca-Serra, Claudine Schiff, Cécile Tonnelle
      Pages 97-114
  3. Serologic and Structural Correlates of Idiotypes

    1. Front Matter
      Pages 129-129
    2. Edgar Haber, Michael N. Margolies
      Pages 141-170
    3. J. Latham Claflin, Jacqueline Wolfe, Anne Maddalena, Susan Hudak
      Pages 171-195
    4. Daniélé Primi, Dominique Juy, Pierre-André Cazenave
      Pages 197-212
    5. R. Jerrold Fulton, Moon H. Nahm, Neil S. Greenspan, Joseph M. Davie
      Pages 213-223
    6. Henry G. Kunkel
      Pages 237-246
  4. Regulation of Idiotypes

    1. Front Matter
      Pages 247-247
    2. Dorith Zharhary, Richard L. Riley, Barbara G. Froscher, Norman R. Klinman
      Pages 249-259

About this book

Introduction

The phenomenon of idiotypy was discovered almost thirty years ago, but it was only during the past decade that it attracted widespread interest and became the subject of numerous research investigations. From the outset, much of the interest in idiotypy was based on its implications with respect to the repertoire of antibodies. Kunkel showed, for example, that idiotypes associated with certain human myeloma or Bence-Jones proteins were present in normal human globulins at levels of less than one part per million. Also, Oudin's original definition of idiotypy implied that idiotypes could be uniquely associated with individual rabbits as well as with particular antigen-binding specificities. Such observations provided some of the earliest evidence for an extensive repertoire of immunoglobulin molecules. The implications of these findings have been amply confirmed by recent studies of protein struc­ ture and molecular genetics; many of these studies are reviewed in the present volume. It is known now that the diversity of antibodies is based on the presence of numerous V and L V H genes, on recombinatorial events involving D and] segments, on somatic mutations, and on processes involving deletion of DNA followed by repair with errors, including inser­ tions. Each of these parameters is capable of influencing the idiotype expressed by the final immunoglobulin product. Regulation of the immune response is another area in which idiotypy has significantly influenced modern immunology.

Keywords

antibody antigen genetics immune response immunoglobulin immunology molecular genetics proteins

Editors and affiliations

  • Mark I. Greene
    • 1
  • Alfred Nisonoff
    • 2
  1. 1.Department of PathologyHarvard Medical SchoolBostonUSA
  2. 2.Rosenstiel Research CenterBrandeis UniversityWalthamUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-4739-2
  • Copyright Information Springer-Verlag US 1984
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-4741-5
  • Online ISBN 978-1-4684-4739-2
  • About this book