Abstract
To initiate replication influenza viruses bind to sialic acid residues of membrane glycoconjugates and are taken into intracellular vesicles by endocytosis. Fusion of virus membranes and endosomal membranes occurs and virus transcription complexes are transferred to cell nuclei where virus messenger RNAs are synthesized. The translation of these messengers leads to the production of the proteins involved in RNA replication, in virus assembly, and in the release of progeny virus particles from the cell by budding at the plasma membrane. Each of these processes in the replication cycle will be considered in turn to indicate possible targets for inhibitors of virus production.
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References
A. Gottschalk, in: “The Viruses” Vol 3, F. M. Burnet and W. M. Stanley, eds., Academic Press (1959) pp. 51–61.
G. N. Rogers, J. C. Paulson, R. S. Daniels, J. J. Skehel, I. A. Wilson and D. C. Wiley, Nature (1983) in press.
I. A. Wilson, J. J. Skehel and D. C. Wiley. Nature 289: 368 (1981).
J. M. Whie and A. Helenius, Proc. Natl. Acad. Sci. USA 77: 3273 (1980).
P. Vaananen and L. Kaariainen, J. gen. Virol. 46: 467 (1980).
T. Maeda and S. Ohnishi, Febs Lett. 122: 283 (1980).
R. T. C. Huang, R. Rott and H.-D. Klenk, Virology 110: 243 (1981).
C. M. Brand and J. J. Skehel, Nature New Biol. 238: 145 (1972).
J. J. Skehel, P. M. Bayley, E. B. Brown, S. R. Martin, M. D. Waterfield, J. M. White, I. A. Wilson and D. C. Wiley, Proc. Natl. Acad. Sci. 79: 968 (1982).
J. M. White, K. Martin and A. Helenius, J. Cell. Biol. 89: 674 (1981).
J. J. Skehel and M.D. Waterfield, Proc. Natl. Acad. Sci., 72: 93 (1975).
R. S. Daniels, A. R. Douglas, J. J. Skehel, M. D. Waterfield, I. A. Wilson and D. C. Wiley, in: “The Origin of Pandemic Influenza Viruses”, C. M. Chu and W. G. Laver, eds., (1982) in press.
C. J. Galloway, G. E. Dean, M. Marsh, G. Rudnick and I. Mellman, Proc. Natl. Acad. Sci. 80: 3334 (1983).
J. W. McCauley and B. W. J. Mahy, Biochem. J. 211: 281 (1983).
J. J. Skehel and A. J. Hay, Nucleic Acids Res. 5: 1207 (1978).
J. S. Robertson, Nucleic Acids Res. 6: 3745 (1979).
U. Desselberger, V. R. Racionello, J. J. Zazra and P. Palese, Gene 8:315 (1 980).
I. Ulmanen, B. A. Broni and R. M. Krug. Proc. Natl. Acad. Sci. 78:7355 (1981)
S. J. Plotch, M. Bouloy, I. Ulmanen and R. M. Krug, Cell 23:81+7 (1981).
R. Dhar, R. M. Chanock and C. J. Lai, Cell 21:1+95 (1980).
A. J. Caton and J. S. Robertson, Nucleic Acids Res. 8: 2591 (1980).
J. S. Robertson, M. Schubert and R. A. Lazzarini, J. Virol. 38: 157 (1981).
N. Proudfoot, Nature 298: 516 (1982).
A. J. Hay, J. J. Skehel and J. McCauley, Virology 116: 517 (1982).
C. Scholtissek, Adv. Genet. 20: 1 (1979).
Ulmanen, I., Broni, B. and Krug, R.M. Proc. Natl. Acad. Sci., 78: 7355 (1981).
D. Blaas, E. Patzelt and E. Kuechler, Nucleic Acids Res. 10: 4803 (1982).
M. A. Horisberger, Virology 120: 279 (1982).
I. Ulmanen, B. Broni and R. M. Krug, J. Virol. 45: 27 (1983).
A. R. Beaton and R. M. Krug, Nucleic Acids Res. 9: 4423 (1981)
A. J. Hay and J. J. Skehel, Br. Med. Bull. 35: 47 (1979).
G. L. Smith and A. J. Hay, Virology, 118: 96 (1982).
G. K. Hirst, Cold Spring Harb. Symp. Quant. Biol. 27:303 (1962)•
W. G. Laver and J. C. Downie, Virology 70: 105 (1976).
M. D. Lubeck, P. Palese and J. L. Schulman, Virology 95: 269 (1979).
J. N. Varghese, W. G. Laver and P. M. Colman, Nature 303: 35 (1983).
A. Gregoriades and B. Frangione, J. Virol. 40: 323 (1981).
D. J. Bucher, I. G. Kharitonenkov, J. A. Zakomiridiu, V. B. Grigoriev, S. M. Klimenko and J. F. Davis, J. Virol. 36: 586 (1980).
A. Gregoriades, Virology 54: 369 (1973).
A. J. Hay and J. J. Skehel, in: “Negative Strand Viruses”, B:6.3. J Maby and R. D. Barry, eds., Academic Press, N.Y.
C. M. Ward, Current Topics in Microbiol. and Immunol. (1982).
J. Zavada, J. gen. Virol. 63: 15 (1982).
A. J. Hay, N. C. T. Kennedy, J. J. Skehel and G. Appleyard, J. gen. Virol. 42: 189 (1979).
M. D. Lubeck, J. L. Schulman and P. Palese, J. Virol. 28: 710 (1978).
M. F. Schmidt, Virology 116: 327 (1982).
J. Blok, G. M. Air, W. G. Laver, C. W. Ward, G. G. Lilley, E. F. Woods, C. M. Roxburgh and A. S. Inglis, Virology 119: 109 (1982).
H.-D. Klenk, R. Rott, M. Orlich and J. Blodorn, Virology 68: 426 (1975).
S. G. Lazarowitz and P. W. Choppin, Virology 68: 440 (1975).
P. Palese, T. Tobita and M. Ueda, Virology 61: 397 (1974).
D. Bucher and P. Palese, in: “Influenza Viruses and Influenza”, E. D. Kilbourne, ed., Academic Press, N.Y., pp 84–123 (1975).
P. M. Colman, J. N. Varghese and W. G. Laver, Nature 303: 41 (1983).
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Skehel, J.J., Wiley, D.C. (1984). Targets for the Design of Antiviral Agents: Targets in Orthomyxoviruses. In: De Clercq, E., Walker, R.T. (eds) Targets for the Design of Antiviral Agents. NATO ASI Series, vol 73. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4709-5_5
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DOI: https://doi.org/10.1007/978-1-4684-4709-5_5
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