Abstract
Considerable efforts have been made to investigate the patho-physiology of brain edema. Results have been obtained on the spread of edema , biochemical alterations2 , water content6 and elevation of intracranial pressure5. Our field of interest was tissue oxygenation and autoregulation of local oxygen supply in edematous cerebral tissue compared to normal brain. With a multiwire micro-surface electrode, PO2 histograms were made under various conditions as well as PO2 changes measured after complete arrest of cerebral blood flow. In addition a hydrogen clearance technique was used to measure local cerebral blood flow. The influence of various anesthetics such as Pentobarbital and Ketamine was studied.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aukland K, Bower BF, Berliner RW: Measurement of local blood flow with hydrogen gas. Circulation Research 14: 164–187 (1964).
Bingham WG Jr, Paul SE, Suryanarayana Sastry KS: Effects of cold injury on six enzymes in rat brain. Arch Neurol 21: 649–660 (1969).
Clasen RA, Cooke PM, Pandolfi S, Boyd’ D, Raimondi AJ: Experimental cerebral edema produced by focal freezing. I Neuropath Exp Neurol, 21: 579–596 (1962).
Gaab M, Pflughaupt KW: Experimentelle und klinische Untersuchungen zur intravenösen Glycerintherapie beim Hirnödem. Acta neurochir 37: 17–31 (1977).
Gaab M: Die Registrierung des intrakraniellen Druckes, Techniken, Ergebnisse und Möglichkeiten. Habil Schr, Würzburg: Medizinische Fakultät (1980).
Herrmann F, Gaab M, Pflughaupt KW, Gruss P: Medikamentöse Therapie beim experimentellen Hirnödem. Neurochirurgia, 24: 39–46 (1981).
Holbach KH, Gött U: Effect of hyperbaric oxygénation therapy (HOT) on neurosurgical patients. In: Proceeding of the 4th intern congr on hyperbaric medicine. Wada J, Iva T (Eds), Tokyo: Igaku Shoin 442–447 (1970).
Leniger-Follert E, Lubbers DW, Wrabetz W: Regulation of local tissue PO2 of the brain cortex at different arterial O2 pressures. Pflügers Arch 359: 81–95 (1975).
Lubbers DW: Local tissue PO2: Its measurement and meaning. In: Oxygen supply, Kessler M, Bruley DF, Lubbers DW, Silver IA, Strauss J (Eds), Urban und Schwarzenberg, München, Berlin, Wien, 151–155 (1973).
Lubbers DW: Die Bedeutung des lokalen Gewebesauerstoffdruckes und des PO2-Histogrammes für die Beurteilung der Sauerstoffversorgung eines Organes. Prakt Anästh, 12: 184–193 (1977).
Manz HJ: The pathology of cerebral edema. Human pathology 5: 291–306 (1974).
Metzger H, Erdmann W, Heidenreich J: Local H2 clearance and P02-measurements in microareas of the brain tissue in rats. In: Cerebral blood flow, clinical and experimental results. Brock M, Fieschi C, Ingvar DH, Lassen NA, Schürmann K (Eds), Springer Verlag, Heidelberg, 42–43 (1969).
Reneau DD, Halsey JH: Interpretation of oxygen disappearance rates in brain cortex following total ischeamia. In: Oxygen transport to tissue, Silver IA, Erecinska M, Bicher HI (Eds), Plenum Press New York, 189–198 (1978).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Heller, V., Poch, B., Gaab, M., Sold, M., Heissler, H.E. (1984). O2 Availability and O2 Metabolism in Cold Induced Brain Edema. In: Go, K.G., Baethmann, A. (eds) Recent Progress in the Study and Therapy of Brain Edema. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4616-6_39
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4616-6_39
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4618-0
Online ISBN: 978-1-4684-4616-6
eBook Packages: Springer Book Archive