Formation of N-Nitroso Compounds and Their Significance

  • William Lijinsky
Part of the Topics in Chemical Mutagenesis book series (TCM, volume 1)


Nitrosamines were first made more than 100 years ago by the simplest means, reaction of secondary amines with nitrous acid. They were not known to have adverse biological effects until 1937, when a case of poisoning by N-nitrosodimethylamine was reported but largely ignored.(1) A detailed investigation of the toxicity of nitrosodimethylamine began in England in the 1950s as a result of another accidental poisoning, the first results being reported by Barnes and Magee in 1954.(2)


Secondary Amine Tertiary Amine Sodium Nitrite Sulfamic Acid Nitroso Compound 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • William Lijinsky
    • 1
  1. 1.Chemical Carcinogenesis ProgramNCI-Frederick Cancer Research FacilityFrederickUSA

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