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Formation of N-Nitroso Compounds and Their Significance

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Genotoxicology of N-Nitroso Compounds

Part of the book series: Topics in Chemical Mutagenesis ((TCM,volume 1))

Abstract

Nitrosamines were first made more than 100 years ago by the simplest means, reaction of secondary amines with nitrous acid. They were not known to have adverse biological effects until 1937, when a case of poisoning by N-nitrosodimethylamine was reported but largely ignored.(1) A detailed investigation of the toxicity of nitrosodimethylamine began in England in the 1950s as a result of another accidental poisoning, the first results being reported by Barnes and Magee in 1954.(2)

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Authors and Affiliations

  1. Chemical Carcinogenesis Program, NCI-Frederick Cancer Research Facility, Frederick, Maryland, 21701, USA

    William Lijinsky

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  1. William Lijinsky
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Editors and Affiliations

  1. Environmental Health Research and Testing, Inc., 27709, Research Triangle Park, North Carolina, USA

    T. K. Rao

  2. Chemical Carcinogenesis Program, NCI-Frederick Cancer Research Facility, 21701, Frederick, Maryland, USA

    W. Lijinsky

  3. Biology Division, Oak Ridge National Laboratory, 37830, Oak Ridge, Tennessee, USA

    T. K. Rao  & J. L. Epler  & 

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© 1984 Plenum Press, New York

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Lijinsky, W. (1984). Formation of N-Nitroso Compounds and Their Significance. In: Rao, T.K., Lijinsky, W., Epler, J.L. (eds) Genotoxicology of N-Nitroso Compounds. Topics in Chemical Mutagenesis, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4595-4_1

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  • DOI: https://doi.org/10.1007/978-1-4684-4595-4_1

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