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Comparison of the Sensitivity of Rodent and Human Cells to Chemical Carcinogens Using Viral Transformation, DNA Damage, and Cytotoxicity Assays

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Organ and Species Specificity in Chemical Carcinogenesis

Part of the book series: Basic Life Sciences ((BLSC))

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Abstract

The close association between the mutagenic and carcinogenic activity of chemicals and their interaction with cell DNA has focused attention on assays that directly or indirectly measure damage to cellular DNA. Three such assays -- enhancement of viral transformation, analysis of DNA breakage, and stimulation of unscheduled DNA synthesis (UDS) -- have been used extensively in hamster embryo cells to determine the potential of these assays as predictors of carcinogenic activity of various environmental chemicals.

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References

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Author information

Authors and Affiliations

  1. Northrop Services, Inc., Research Triangle Park, North Carolina, 27709, USA

    Bruce C. Casto

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  1. Bruce C. Casto
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Editor information

Editors and Affiliations

  1. U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Robert Langenbach  & Stephen Nesnow  & 

  2. National Cancer Institute, Bethesda, Maryland, USA

    Jerry M. Rice

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© 1983 Plenum Press, New York

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Casto, B.C. (1983). Comparison of the Sensitivity of Rodent and Human Cells to Chemical Carcinogens Using Viral Transformation, DNA Damage, and Cytotoxicity Assays. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_23

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  • DOI: https://doi.org/10.1007/978-1-4684-4400-1_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4402-5

  • Online ISBN: 978-1-4684-4400-1

  • eBook Packages: Springer Book Archive

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