Comparison of the Sensitivity of Rodent and Human Cells to Chemical Carcinogens Using Viral Transformation, DNA Damage, and Cytotoxicity Assays

  • Bruce C. Casto
Part of the Basic Life Sciences book series


The close association between the mutagenic and carcinogenic activity of chemicals and their interaction with cell DNA has focused attention on assays that directly or indirectly measure damage to cellular DNA. Three such assays -- enhancement of viral transformation, analysis of DNA breakage, and stimulation of unscheduled DNA synthesis (UDS) -- have been used extensively in hamster embryo cells to determine the potential of these assays as predictors of carcinogenic activity of various environmental chemicals.


Chemical Carcinogen Comparative Sensitivity Polycyclic Hydrocarbon Human Embryonic Lung Viral Transformation 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Bruce C. Casto
    • 1
  1. 1.Northrop Services, Inc.Research Triangle ParkUSA

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