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DNA Chain Elongation Mechanism of DNA Polymerases α, β and γ

  • Chapter
New Approaches in Eukaryotic DNA Replication

Abstract

There are many lines of evidence that indicate the existence of at least two kinds of DNA replication mechanisms in eukaryotic cells.

  1. (1)

    One is that observed in nuclear DNA replication, where DNA chains (at least the lagging strand) are synthesized in relatively short pieces (3–5s) that are later elongated and joined together1–6. These short DNA intermediates are also observed in the replication of viral DNA such as polyoma virus7,8 and simian virus (SV)4O9,10.

  2. (2)

    The other is that for adenovirus DNA11-12 and mitochondrial DNA13. These DNA’s are not replicated via Okazaki pieces as the intermediates, but replicated in a continuous mode.

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Authors and Affiliations

  1. Laboratory of Biochemistry, Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya 464, Japan

    Akio Matsukage, Masamitsu Yamaguchi, Kazushi Tanabe, Yukari N. Taguchi, Miwako Nishizawa & Taijo Takahashi

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  1. Akio Matsukage
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  2. Masamitsu Yamaguchi
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  3. Kazushi Tanabe
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  4. Yukari N. Taguchi
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  5. Miwako Nishizawa
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  6. Taijo Takahashi
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Editors and Affiliations

  1. Institute of Scientific Research on Cancer, Villejuif, France

    A. M. de Recondo

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© 1983 Plenum Press, New York

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Matsukage, A., Yamaguchi, M., Tanabe, K., Taguchi, Y.N., Nishizawa, M., Takahashi, T. (1983). DNA Chain Elongation Mechanism of DNA Polymerases α, β and γ. In: de Recondo, A.M. (eds) New Approaches in Eukaryotic DNA Replication. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4397-4_4

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  • DOI: https://doi.org/10.1007/978-1-4684-4397-4_4

  • Publisher Name: Springer, Boston, MA

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