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New Approaches in Eukaryotic DNA Replication

  • A. M. de Recondo

Table of contents

  1. Front Matter
    Pages i-viii
  2. Replication Machinery

    1. Front Matter
      Pages 1-1
    2. David Korn, Paul A. Fisher, Teresa Shu-Fong Wang
      Pages 17-55
    3. Marcel Mechali, Anne-Marie de Recondo
      Pages 57-80
    4. Akio Matsukage, Masamitsu Yamaguchi, Kazushi Tanabe, Yukari N. Taguchi, Miwako Nishizawa, Taijo Takahashi
      Pages 81-106
    5. Peter C. van der Vliet, Marijke M. Kwant, Bram G. M. van Bergen, Wim van Driel
      Pages 107-122
    6. Patrick Forterre, Liliane Assairi, Michel Duguet
      Pages 123-176
  3. Regulation of DNA Replication

    1. Front Matter
      Pages 177-177
    2. M. Yaniv, S. Saragosti, G. Moyne
      Pages 193-201
    3. Melvin L. DePamphilis, Michael E. Cusick, Ronald T. Hay, Cynthia Pritchard, Lois C. Tack, Paul M. Wassarman et al.
      Pages 203-233
    4. Masamichi Kohiyama, Annick Jacq, Claude Reiss
      Pages 235-245
    5. Jacqueline Louarn, Philippe Legrand, Josette Patte, Jean-Michel Louarn
      Pages 247-263
    6. Roger Hand, Eric Eilen, Claudio Basilico
      Pages 265-275
  4. Repair of DNA Damage

    1. Front Matter
      Pages 293-293
    2. Mutsuo Sekiguchi, Hiroshi Hayakawa, Katsumi Yamashita, Kenji Shimizu
      Pages 295-312
    3. Alain Sarasin, Jean-Michel Rossignol, Michel Philippe
      Pages 313-332
  5. Back Matter
    Pages 343-365

About this book

Introduction

DNA replication in eukaryotes is an important field, particular­ ly because of its direct impact on the study of cancer. The under­ standing of molecular mechanisms of replication and their regulation should allow a better comprehension of the alterations that lead to the proliferation of tumor cells and to error-prone repair in cells exposed to radiation or chemical carcinogens. During the last several years, many enzymes and proteins which participate in replication of DNA in eukaryotic cells have been identified, isolated and characterized. New concepts in chromatin structure have refocused attention on the study of replication of DNA complexed with his tones and non-histone chromosomal proteins. However, progress has been noticeably slower than for prokaryotes, essentially because of the difficulty in genetic analysis of eukaryo­ tic DNA replication. In June 1980, a workshop was organized in Cargese, Corsica (France) to facilitate exchanges of information between workers spe­ cializing in prokaryotes and those specializing in eukaryotes, and to allow discussion of new experimental approaches. With this in mind, special interest has been taken in the origin and termination of chromosome cycles and how they are controlled.

Keywords

DNA Elongation Termination attention cancer cells chromosome enzymes lead proliferation protein proteins radiation regulation tumor

Editors and affiliations

  • A. M. de Recondo
    • 1
  1. 1.Institute of Scientific Research on CancerVillejuifFrance

Bibliographic information