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New Approaches in Eukaryotic DNA Replication

  • Book
  • © 1983

Overview

Editors:
  1. A. M. Recondo

    1. Institute of Scientific Research on Cancer, Villejuif, France

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-viii
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  2. Replication Machinery

    1. Front Matter

      Pages 1-1
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    2. Enzymatic Mechanisms in DNA Replication: Initiation of Strands

      • Arthur Kornberg
      Pages 3-15

    3. Enzymological Characterization of Human DNA Polymerases-α and β

      • David Korn, Paul A. Fisher, Teresa Shu-Fong Wang
      Pages 17-55

    4. Structural Analysis of Eukaryotic DNA Polymerase-α

      • Marcel Mechali, Anne-Marie de Recondo
      Pages 57-80

    5. DNA Chain Elongation Mechanism of DNA Polymerases α, β and γ

      • Akio Matsukage, Masamitsu Yamaguchi, Kazushi Tanabe, Yukari N. Taguchi, Miwako Nishizawa, Taijo Takahashi
      Pages 81-106

    6. Adenovirus DNA Replication: Mechanism and Replication Proteins

      • Peter C. van der Vliet, Marijke M. Kwant, Bram G. M. van Bergen, Wim van Driel
      Pages 107-122

    7. Topology, Type II DNA Topoisomerases and DNA Replication in Prokaryotes and Eukaryotes

      • Patrick Forterre, Liliane Assairi, Michel Duguet
      Pages 123-176

  3. Regulation of DNA Replication

    1. Front Matter

      Pages 177-177
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    2. Protein Phosphorylation and Chromatin Replication: Studies on the Interaction of Two Nuclear Proteins with DNA

      • Hans Stahl, Herbert König, Rolf Knippers
      Pages 179-192

    3. Structure and Replication of SV40 Chromatin

      • M. Yaniv, S. Saragosti, G. Moyne
      Pages 193-201

    4. Chromatin Structure, DNA Sequences and Replication Proteins: Searching for the Principles of Eukaryotic Chromosome Replication

      • Melvin L. DePamphilis, Michael E. Cusick, Ronald T. Hay, Cynthia Pritchard, Lois C. Tack, Paul M. Wassarman et al.
      Pages 203-233

    5. Recognition of Origin of Replication by Initiation Factors in Escherichia Coli

      • Masamichi Kohiyama, Annick Jacq, Claude Reiss
      Pages 235-245

    6. The Terminus of Chromosome Replication of E. coli Phenotypic Suppression of a dnaA Mutation by Plasmid Integration near terC

      • Jacqueline Louarn, Philippe Legrand, Josette Patte, Jean-Michel Louarn
      Pages 247-263

    7. A Mutation that Blocks Initiation of DNA Synthesis in Hamster Cells

      • Roger Hand, Eric Eilen, Claudio Basilico
      Pages 265-275

    8. Polyoma and Cell Chromatin Replication Studied in Mouse Cells which Exhibit Temperature-Sensitive DNA Synthesis because they are Sts or G1 ts

      • Rose Sheinin, Richard Colwill, Peter R. Ganz
      Pages 277-291

  4. Repair of DNA Damage

    1. Front Matter

      Pages 293-293
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    2. Mechanisms of DNA Repair as Revealed by Artificial Introduction of Enzymes into Viable Cells

      • Mutsuo Sekiguchi, Hiroshi Hayakawa, Katsumi Yamashita, Kenji Shimizu
      Pages 295-312

    3. DNA Polymerases and DNA Repair in Eukaryotic Cells

      • Alain Sarasin, Jean-Michel Rossignol, Michel Philippe
      Pages 313-332

    4. Stimulation of Reca Protein Dependent Strand Assimilation and DNA Complex Formation by Single-Stranded DNA Binding Proteins

      • George M. Weinstock, Kevin McEntee, I. Robert Lehman
      Pages 333-341
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Keywords

About this book

DNA replication in eukaryotes is an important field, particular­ ly because of its direct impact on the study of cancer. The under­ standing of molecular mechanisms of replication and their regulation should allow a better comprehension of the alterations that lead to the proliferation of tumor cells and to error-prone repair in cells exposed to radiation or chemical carcinogens. During the last several years, many enzymes and proteins which participate in replication of DNA in eukaryotic cells have been identified, isolated and characterized. New concepts in chromatin structure have refocused attention on the study of replication of DNA complexed with his tones and non-histone chromosomal proteins. However, progress has been noticeably slower than for prokaryotes, essentially because of the difficulty in genetic analysis of eukaryo­ tic DNA replication. In June 1980, a workshop was organized in Cargese, Corsica (France) to facilitate exchanges of information between workers spe­ cializing in prokaryotes and those specializing in eukaryotes, and to allow discussion of new experimental approaches. With this in mind, special interest has been taken in the origin and termination of chromosome cycles and how they are controlled.

Editors and Affiliations

  • Institute of Scientific Research on Cancer, Villejuif, France

    A. M. Recondo

Bibliographic Information

  • Book Title: New Approaches in Eukaryotic DNA Replication

  • Editors: A. M. Recondo

  • DOI: https://doi.org/10.1007/978-1-4684-4397-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1983

  • Softcover ISBN: 978-1-4684-4399-8Published: 17 March 2012

  • eBook ISBN: 978-1-4684-4397-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 366

  • Topics: Human Genetics

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