Ia Determinants on Macrophages: Significance and Role in the Immune Response
Since the discovery that macrophages are essential for the resistance to intracellular infection, these mononuclear cells have become recognized as being important not only in nonspecific but also in specific immunity. There is now general agreement that the induction of any immune response is dependent on macrophages. However, besides macrophages, other cells which are not considered to belong to the macrophage lineage are also involved in the induction of at least some immune processes. Thus, these “inducer” cells are heterogeneous and the use of the term “accessory cells” instead of macrophages seems to be more appropriate to describe these cells. However, as most of the evidence provided in this paper directly concerns the classical macrophage the term “macrophage” will be used, keeping in mind that the functional activities described will not necessarily be restricted to this particular cell type.
KeywordsSpleen Cell Helper Cell Accessory Cell Peritoneal Exudate Cell Splenic Macrophage
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