Advertisement

Ia Determinants on Macrophages: Significance and Role in the Immune Response

  • Peter Erb
  • Angelika C. Stern
  • Michael J. Cecka
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)

Abstract

Since the discovery that macrophages are essential for the resistance to intracellular infection, these mononuclear cells have become recognized as being important not only in nonspecific but also in specific immunity. There is now general agreement that the induction of any immune response is dependent on macrophages. However, besides macrophages, other cells which are not considered to belong to the macrophage lineage are also involved in the induction of at least some immune processes. Thus, these “inducer” cells are heterogeneous and the use of the term “accessory cells” instead of macrophages seems to be more appropriate to describe these cells. However, as most of the evidence provided in this paper directly concerns the classical macrophage the term “macrophage” will be used, keeping in mind that the functional activities described will not necessarily be restricted to this particular cell type.

Keywords

Spleen Cell Helper Cell Accessory Cell Peritoneal Exudate Cell Splenic Macrophage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Rosenthal, A. S., and Shevach, E. M., J, Exp. Med. 138:1194, 1973.CrossRefGoogle Scholar
  2. 2.
    Erb, P., and Feldmann, M., Nature 254:352, 1975.PubMedCrossRefGoogle Scholar
  3. 3.
    Erb, P., and Feldmann, M., J. Exp. Med. 142:460, 1975.PubMedCrossRefGoogle Scholar
  4. 4.
    Miller, J. F. A. P., Vadas, M. A., Whitelaw, A., and Gamble, J., Proc. Natl. Acad. Sci. USA 72:5039, 1975.Google Scholar
  5. 5.
    Kappler, J. W., and Marrack, P. C., Nature 262:797, 1976.PubMedCrossRefGoogle Scholar
  6. 6.
    Pierce, C. W., Kapp, J. A., and Benacerraf, B., J. Exp. Med. 144:371, 1976.PubMedCrossRefGoogle Scholar
  7. 7.
    Thomas, D. W., and Shevach, E. M., J. Exp. Med. 144:1236, 1976.Google Scholar
  8. 8.
    Yano, A., Schwartz, R. H., and Paul, W. E., J. Exp. Med. 146:828, 1977.PubMedCrossRefGoogle Scholar
  9. 9.
    Farr, A. G., Dorf, M. E., and Unanue, E. R., Proc. Natl. Acad. Sci. USA 74:3542, 1977.PubMedCrossRefGoogle Scholar
  10. 10.
    Erb, P., and Feldmann, M., Eur. J. Immunol. 5:759, 1975.PubMedCrossRefGoogle Scholar
  11. 11.
    Erb, P., Feldmann, M., and Hogg, N., Eur. J. Immunol. 6:365, 1976.PubMedCrossRefGoogle Scholar
  12. 12.
    Puri, J., and Lonai, P., Eur. J. Immunol. 10:273, 1980.PubMedCrossRefGoogle Scholar
  13. 13.
    Unanue, E. R., Dorf, M. E., David, C. S., and Benacerraf, B., Proc. Natl. Acad. Sci. USA 71:5014, 1974.PubMedCrossRefGoogle Scholar
  14. 14.
    Schwartz, R. H., Dickler, H. B., Sachs, D. H., and Schwartz, B. D., Scand. J. Immunol. 5:731, 1976.PubMedCrossRefGoogle Scholar
  15. 15.
    Cowing, C., Schwartz, B. D., and Dickler, H. B., J. Immunol. 120:378, 1978.PubMedGoogle Scholar
  16. 16.
    Weinberg, D. S., and Unanue, E. R., J. Immunol. 126:794, 1981.PubMedGoogle Scholar
  17. 17.
    Lipscomb, M. F., Toews, G. B., Lyons, C. R., and Uhr, J. W., J. Immunol. 126:286, 1981.PubMedGoogle Scholar
  18. 18.
    Beller, D. I., and Unanue, E. R., J. Immunol. 124:1433, 1980.PubMedGoogle Scholar
  19. 19.
    Henry, C., Goodman, J. R., Chan, E., Kimura, J., Lucas, A., and Wofsy, L., J. Reticuloendothelial Soc. 26:787, 1979.Google Scholar
  20. 20.
    Stern, A. C., Erb, P., and Gisler, R. H., J. Immunol. 123:612, 1979.PubMedGoogle Scholar
  21. 21.
    Frelinger, J. G., Wettstein, P. J., Frelinger, J. A., and Hood, L., Immunogenetics 6:125, 1978.CrossRefGoogle Scholar
  22. 22.
    Stingl, G., Katz, S. I., Abelson, L. D., and Mann, D. L., J. Immunol. 120:661, 1978.PubMedGoogle Scholar
  23. 23.
    Richman, L. K., Klingenstein, R. J., Richman, J. A., Strober, W., and Berzofsky, J. A., J. Immunol. 123:2602, 1979.PubMedGoogle Scholar
  24. 24.
    Hoffmann-Fezer, G., Götze, D., Rodt, H., and Thierfelder, S., Immunogenetics 6:367, 1978.CrossRefGoogle Scholar
  25. 25.
    Steinman, R. M., Kaplan, G., Witmer, M., and Cohn, Z. A., J. Exp. Med. 149:1, 1979.PubMedCrossRefGoogle Scholar
  26. 26.
    Schrader, J. W., and Nossal, G. J. V., Immunol. Rev. 53:61, 1980.PubMedCrossRefGoogle Scholar
  27. 27.
    McKean, D. J., Infante, A. J., Nilson, A., Kimoto, M., Fathman, C. G., Walker, E., and Warner, N., J. Exp. Med. 154:1419, 1981.PubMedCrossRefGoogle Scholar
  28. 28.
    Cohen, D. A., and Kaplan, A. M., J. Exp. Med. 154:1881, 1981.PubMedCrossRefGoogle Scholar
  29. 29.
    Buchmiieller, Y., Mauël, J., and Corradin, G., in “Macrophages and Natural Killer Cells: Regulation and function” (S. Normann and E. Sorkin, eds.), pp. 557–561, Plenum Press, New York, 1982.Google Scholar
  30. 30.
    Beller, D. I., and Unanue, E. R., J. Immunol. 126:263, 1981.PubMedGoogle Scholar
  31. 31.
    Beller, D. I., Kiely, J. M., and Unanue, E. R., J. Immunol. 124:1426, 1980.PubMedGoogle Scholar
  32. 32.
    Ezekowitz, A. B., Austyn, J., Stahl, P. D., and Gordon, S., J. Exp. Med. 154:60, 1981.PubMedCrossRefGoogle Scholar
  33. 33.
    Steeg, P. S., Morre, R. N., and Oppenheim, J. J., J. Exp. Med. 152:1734, 1980.PubMedCrossRefGoogle Scholar
  34. 34.
    Steinman, R. M., Nogueira, N., Witmer, M. D., Tydings, J. D., and Mellman, I. S., J. Exp. Med. 152:148, 1980.CrossRefGoogle Scholar
  35. 35.
    Nussenzweig, M. C., Steinman, R. M., Gutchinov, B., and Cohn, Z. A., J. Exp. Med. 152:1070, 1980.PubMedCrossRefGoogle Scholar
  36. 36.
    Scher, M. G., Beller, D. I., and Unanue, E. R., J. Exp. Med. 152:1684, 1980.PubMedCrossRefGoogle Scholar
  37. 37.
    Lee, K. C., and Wong, M., J. Immunol. 125:86, 1980.PubMedGoogle Scholar
  38. 38.
    Mottram, P. L., and Miller, J. F. A. P., Eur. J. Immunol. 10:165, 1980.PubMedCrossRefGoogle Scholar
  39. 39.
    Rosenthal, A. S., Barcinski, M. A., and Blake, J. T., Nature 267:156, 1977.PubMedCrossRefGoogle Scholar
  40. 40.
    Rosenwasser, L. J., and Huber, B. T., J. Exp. Med. 153:1113, 1981.PubMedCrossRefGoogle Scholar
  41. 41.
    Lin, C. C., Rosenthal, A. S., Passmore, H. C., and Hansen, T. H., Proc. Natl. Acad. Sci. USA 78:6406, 1981.PubMedCrossRefGoogle Scholar
  42. 42.
    Grossman, Z., and Cohen, I. R., Eur. J. Immunol. 10:633, 1980.PubMedCrossRefGoogle Scholar
  43. 43.
    Araneo, B. A., Jowell, R. L., and Sercarz, E. E., J. Immunol. 123:961, 1979.PubMedGoogle Scholar
  44. 44.
    Stötter, H., Imm, A., Meyer-Delius, M., and Rüde, E., J. Immunol. 127:8, 1981.PubMedGoogle Scholar
  45. 45.
    Ishii, N., Baxevanis, C. N., Nagy, Z. A., and Klein, J., J. Exp. Med. 154:978, 1981.PubMedCrossRefGoogle Scholar
  46. 46.
    Kimoto, M., Krenz, T. J., and Fathman, C. G., J. Exp. Med. 154:883, 1981.PubMedCrossRefGoogle Scholar
  47. 47.
    Erb, P., Stern, A. S., Alkan, S. S., Studer, S., Zoumbou, E., and Gisler, R. H., J. Immunol. 125:2504, 1980.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Peter Erb
    • 1
  • Angelika C. Stern
    • 1
  • Michael J. Cecka
    • 1
  1. 1.Institute for MicrobiologyUniversity of BaselBaselSwitzerland

Personalised recommendations