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Molecular Basis of Self/Non-self Discrimination in the Ectothermic Vertebrates

  • Chapter
Phylogeny and Ontogeny

Abstract

The ability to discriminate self from non-self is fundamental to the organization and survival of metazoan life. This ability resides primarily with the individual cells, although it can be mediated also by specific products secreted by the cells, as will be discussed later. Self/non-self discrimination is essential for the orderly processes of development, differentiation, and organogenesis; in addition, it is required so that an animal can maintain its integrity and prevent invasion and damage by foreign entities, either animate (viruses, bacteria, fungi, metazoan parasites) or inanimate (for example, bacterial exotonins).

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  1. Department of Biochemistry, Medical University of South Carolina, Charleston, South Carolina, 29425, USA

    Gregory W. Warr & John J. Marchalonis

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  2. John J. Marchalonis
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Editors and Affiliations

  1. School of Medicine and Dentistry, The University of Rochester, Rochester, New York, USA

    Nicholas Cohen

  2. University of South Carolina School of Medicine, Columbia, South Carolina, USA

    M. Michael Sigel

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© 1982 Plenum Press, New York

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Warr, G.W., Marchalonis, J.J. (1982). Molecular Basis of Self/Non-self Discrimination in the Ectothermic Vertebrates. In: Cohen, N., Sigel, M.M. (eds) Phylogeny and Ontogeny. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4166-6_14

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  • DOI: https://doi.org/10.1007/978-1-4684-4166-6_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4168-0

  • Online ISBN: 978-1-4684-4166-6

  • eBook Packages: Springer Book Archive

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