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Antigen Receptors of T Helper Cells

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Contemporary Topics in Immunobiology

Part of the book series: Contemporary Topics in Immunobiology ((CTI,volume 7))

Abstract

The function of the immune system is based on a large variety of receptor molecules that differ in their binding specificity. These receptors are located in part on the surfaces of the immunocompetent cells, namely, T and B lymphocytes, and in part appear free in the circulation. They mediate the specific recognition of antigens and guarantee the specificity of the immunologic reactions that follow antigen recognition. In addition, since each receptor molecule carries associated with its specific antigen-binding site specific antigenic determinants (so-called idiotopes) that distinguish it from, and can be recognized by, other receptor molecules, it appears possible that the immune system regulates itself by internal receptor-receptor interactions (Jerne, 1974).

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Authors and Affiliations

  1. Institute for Genetics, University of Cologne, Cologne, West Germany

    Klaus Rajewsky

  2. Institute for Immunology and Genetics, Deutsches Krebsforschungszentrum, Heidelberg, West Germany

    Klaus Eichmann

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  1. Klaus Rajewsky
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  1. Sloan-Kettering Institute for Cancer Research, New York, New York, USA

    Osias Stutman

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Rajewsky, K., Eichmann, K. (1977). Antigen Receptors of T Helper Cells. In: Stutman, O. (eds) Contemporary Topics in Immunobiology. Contemporary Topics in Immunobiology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3054-7_3

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