Biology of Lymphoid Cells Transformed by Epstein—Barr Virus

  • James E. Robinson
  • George Miller
Part of the The Viruses book series (VIRS)


In 1964, M.A. Epstein and Barr (1964) and Pulvertaft (1964a) reported the first successful attempts to establish Continuous lymphoblastoid-cell lines (LCLs) from expiants of Burkitt lymphoma (BL). Subsequent electron-microscopic examination of thin sections of the EB1 Cell line revealed virus particles that were morphologically similar to the herpesvirus group (M.A. Epstein et al., 1964a). In lines derived shortly thereafter from other BL tumors (M.A. Epstein et al., 1964b; Stewart et al., 1965; Rabson et al., 1966; Minowada et al., 1967), viral particles resembling those found in EB1 cells were seen. Such particles were not confined to lines originating from BL tissue, but were also seen in a fraction of cells in lymphoid lines established from patients with various malignancies (Armstrong, 1966; Moore et al., 1966; Zeve et al., 1966), from patients with infectious mononucleosis (IM) (Pope, 1967; Diehl et al., 1968), and from apparently normal individuals (Moore et al., 1967).


Burkitt Lymphoma Raji Cell Infectious Mononucleosis Immunoglobulin Synthesis Human Leukocyte Antigen Antigen 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • James E. Robinson
    • 1
  • George Miller
    • 1
  1. 1.Departments of Pediatrics and Epidemiology and Public HealthYale University School of MedicineNew HavenUSA

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