Abstract
Lymphoid cell lines have been invaluable tools not only in studies of the biologic properties of Epstein-Barr virus (EBV), but also in the fields of oncology, hematology, immunology, genetics, and cell biology. In 1964, Pulvertaft (1964 a) and Epstein and Barr (1964) independently described the first cell lines from tumor biopsies of patients with Burkitt’s lymphoma (BL). Before this, attempts to cultivate normal and malignant hematopoietic tissue in vitro had usually led to a gradual deterioration and subsequent death of the various cell types within weeks or months (Osgood, 1958; Reisner, 1959). Only rarely had permanent cell lines been established from leukemic blood (Osgood and Broke, 1955) and bone marrow (Benyesh-Melnick et al., 1963). In the latter report, the sudden outgrowth of permanent cell lines with a lymphoblastoid morphology was described at a low frequency in fibroblastoid monolayers several weeks after initiation of bone-marrow cultures derived from children with leukemia, infectious mononucleosis (IM) and hemolytic anemia. This remarkable event was termed “lymphoblastoid transformation of fibroblastic bone-marrow cultures.” The meaning of the term “lymphoblastoid transformation” here was thus different from the “lymphoblastoid transformation” used to describe the morphologic changes of normal lymphocytes after exposure to phytohemagglutinin (PHA) (Nowell, 1960).
The author is indebted to Ms. Kerstin Lindberg, Ms. Anna-Greta Lundquist, Ms. Gunilla Aberg, and Ms. Ingalill Sjö for excellent help with the preparation of the manuscript.
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Nilsson, K. (1979). The Nature of Lymphoid Cell Lines and Their Relationship to the Virus. In: Epstein, M.A., Achong, B.G. (eds) The Epstein-Barr Virus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67236-1_11
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