The Alcohol Dehydrogenase Genes of the Yeast, Saccharomyces Cerevisiae: Isolation, Structure, and Regulation
Alcohol dehydrogenase (E.C. 188.8.131.52. ADH) catalyzes the inter-conversion of an alcohol and an aldehyde with NAD+ as a cofactor. In most higher organisms that have been studied, several different isozymes of ADH are present. The main function of these isozymes is presumed to be catabolic, to degrade various alcohols or sterols. This presumption is based primarily on the substrate preferences of the various isozymes and the absence of a fermentative pathway for alcohol production during glycolysis. In many organisms there is a distinctive tissue specificity in the distribution of different ADH isozymes.
KeywordsAlcohol Dehydrogenase Gene ADR2 Gene ADR2 mRNA
Unable to display preview. Download preview PDF.
- 1.Bennetzen, J.L. (1979). Ph.D. Thesis. University of Washington.Google Scholar
- 7.Ciriacy, M. and V.M. Williamson (1981). Analysis of mutations affecting Ty-mediated gene mediated gene expression in Saccharomyces cerevisiae. Mol. Gen. Genet.Google Scholar
- 8.Clark, L. and J. Carbon (1980). Isolation of a yeast centromere and constructure of functional small circular chromosomes.Google Scholar
- 9.Denis, C., E.T. Young, and M. Ciriacy (1981). A positive regulatory gene is required for accumulation of functional mRNA for the glucose-repressible alcohol dehydrogenase from Saccharomyces cerevisiae. J. Mol. Biol.Google Scholar
- 14.Holland, M.J., J.L. Holland, G.P. Thill, and K.A. Jackson (1981). The primary structure of two yeast enolase genes. J. Biol. Chem., 256: 1385–1395.Google Scholar