Skip to main content
SpringerLink
Log in

The Handling of Ingested Antigens

  • Chapter
The Immunology of Infant Feeding

Part of the book series: Ettore Majorana International Science Series ((LIFESCI,volume 8))

  • 33 Accesses

Abstract

The surface area of the intestine is one factor which makes it such an effective absorptive organ but it also permits considerable exposure to the enormous quantities of antigenic material within its lumen. The intestinal mucosa is widely thought to be impermeable to large molecular weight substances and food is generally absorbed in digested form. However, if the contents of the intestine act as antigens they must cross the external chemical and physical barriers in the lumen and gain access to the immune mechanisms within the body. That macromolecules are absorbed has been suspected since 1864 when Stokvis showed that after the ingestion of large amounts of egg proteins patients developed proteinuria and he suggested that some protein was being absorbed intact and secreted by the kidney.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Morris I.G. (1968) in “Handbook of Physiology” vol. 2 p. 1491, Ed. Code C.F., Amer. Physiol. Soc.

    Google Scholar 

  2. Halliday R. (1955) Proc. R. Soc. Series B. Biol. Sci 143: 408.

    Article  CAS  Google Scholar 

  3. Morris I.G. (1963) Proc. R. Soc. London Series B. 157: 160.

    Article  Google Scholar 

  4. Jones E.A. and Waldman T. (1972) J. Clin. Invest. 51: 2915.

    Google Scholar 

  5. Halliday R. (1959) J. Endocrinol. 18: 56.

    Article  PubMed  CAS  Google Scholar 

  6. Lippard V.W., Schloss O.M. and Johnson P.A. (1936) Am. J. Dis. Child. 5: 562.

    Google Scholar 

  7. Rothberg M. (1969) J. Paediat. 75: 391.

    Article  CAS  Google Scholar 

  8. Walker W.A., Cornell R., Davenport L.M. and Isselbacher K.J. (1972) J. Cell Biol. 54: 195.

    Article  PubMed  CAS  Google Scholar 

  9. Clark S.L. (1959) Biophys. Biochem. Cytol. 5: 41.

    Article  Google Scholar 

  10. Brambell F.W.R. (1966) Lancet 2: 1087.

    Article  PubMed  CAS  Google Scholar 

  11. Hillman H. and Sartory P. (1977) Perception 6: 667.

    Article  PubMed  CAS  Google Scholar 

  12. Goldstein J.L., Anderson R.G.W. and Brown M.S. (1979) Nature 279: 679.

    Article  PubMed  CAS  Google Scholar 

  13. Katayama K. and Fujita T. (1972) Biochem. Biophys. Acta 288: 181.

    Article  CAS  Google Scholar 

  14. Warshaw A.L., Walker A.W. and Isselbacher K.J. (1974) Gastroenterology 66: 987.

    PubMed  CAS  Google Scholar 

  15. Jacob A.I., Goldberg P.K., Bloom N., Degenshein M.D. and Kozinn P.J. (1977) Gastroenterology 72: 1268.

    PubMed  CAS  Google Scholar 

  16. Hemmings W.A. and Williams E.W. (1978) Gut 19: 715.

    Article  PubMed  CAS  Google Scholar 

  17. Northrup R.S., Bienenstock J. and Tomasi T.B. (1970) J. Infect. Dis. 121: 137.

    Article  PubMed  Google Scholar 

  18. Dupont H.L., Formal S.B. and Hornick R.S. (1971) N. Eng. J. Med. 285: 1.

    Article  CAS  Google Scholar 

  19. Lake A.M., Bloch K.J., Neutra M.R. and Walker W.A. (1979) J. Immunol. 122: 834.

    PubMed  CAS  Google Scholar 

  20. Danforth E. and Moore R.O. (1959) Endocrinology 5: 118.

    Article  Google Scholar 

  21. Arloing F. and Langeran L. (1923) Compte. Rend. Soc. de Biol. 89: 1293 cited by Ratner & Gruehl (1934).

    Google Scholar 

  22. Makaroff (1923) Compte. Rend. Soc. de Biol. 89: 286 cited by Ratner & Gruehl (1934).

    Google Scholar 

  23. Hutinel (1908) Clinique, Paris, 3: 227 cited by Ratner & Gruehl (1934).

    Google Scholar 

  24. Schloss O.M. and Worthen T.W. (1916) Am. J. Dis. Child. II: 342.

    Google Scholar 

  25. Anderson A.F. and Schloss O.M. (1923) Am. J. Dis. Child. 26: 451.

    CAS  Google Scholar 

  26. Gruskay F.L. and Cooke R.E. (1955) Paediatrics 16: 763.

    CAS  Google Scholar 

  27. Taylor K.B., Turelove S.C., Thomson D.L. and Wright R. (1961) BMJ 11: 1727–1731.

    Article  Google Scholar 

  28. Kumar P.J., Ferguson A., Lancaster-Smith M. and Clark M.L. (1976) Scan. J. Gastroent. 11: 5.

    CAS  Google Scholar 

  29. Taylor K.B. and Truelove S.C. (1973) Lancet 11: 924.

    Google Scholar 

  30. Chandra R.K. (1975) Arch. Dis. Child. 50: 532.

    Article  PubMed  CAS  Google Scholar 

  31. Smith M.W. and Burton K.E. (1972) Anim. Prod. 15: 139.

    Article  CAS  Google Scholar 

  32. Heremans J.F. (1969) “The Secretory Immunologic System” p. 309, Nat. Inst. Child Health and Human Dev., Bethesda.

    Google Scholar 

  33. Walker W.A., Isselbacher K.J. and Bloch K.J. (1972) Science 177: 608

    Article  PubMed  CAS  Google Scholar 

  34. Andre C., Lambert R., Bazin H. and Heremans J.F. (1974) Eur. J. Immunol. 4: 701.

    Article  PubMed  CAS  Google Scholar 

  35. Seifert J., Ring J., Steininger J. and Brendel W. (1977) Nutr. Metab. 21 (suppl. I): 256.

    PubMed  CAS  Google Scholar 

  36. Walker W.A., and Bloch K.J. (1977) Gastroenterology (Abstract) A162/1185.

    Google Scholar 

  37. Swarbrick E.T., Stokes C.R. and Soothill J.F. (1979) Gut 20: 121–125.

    Article  PubMed  CAS  Google Scholar 

  38. Walker W.A., Wu M., Isselbacher K.J. and Bloch K.J. (1975) J. Immunol. 115: 854.

    PubMed  CAS  Google Scholar 

  39. Walker W.A., Wu M., Isselbacher K.J. and Bloch K.J. (1975) Gastroenterology 69: 1223.

    PubMed  CAS  Google Scholar 

  40. Walker W.A., Wu M. and Bloch K.J. (1977) Science 197: 370.

    Article  PubMed  CAS  Google Scholar 

  41. Brown W.R., Newcomb R.W. and Ishizaka K. (1970) J. Clin. Invest. 49: 1374.

    Article  Google Scholar 

  42. Steward M.W. (1971) Biochem. Biophys. Acta 236: 440.

    Article  PubMed  CAS  Google Scholar 

  43. Stokes C.R., Soothill J.F. and Turner M.W. (1975) Nature 255: 745.

    Article  PubMed  CAS  Google Scholar 

  44. Swarbrick E.T., Stokes C.R. and Soothill J.F. (1976) Gut 18: A945.

    Google Scholar 

  45. Paganelli R., Levinsky R.J., Brostoff J. and Wraith D.G. (1979) Lancet i: 1270.

    Google Scholar 

  46. British Medical Bulletin (May 1976) 32 (2).

    Google Scholar 

  47. Waksman B.H. (1977) Clin. Exp. Immunol. 28: 363–374.

    PubMed  CAS  Google Scholar 

  48. Wells H.G. (1911) J. Infect. Dis. 9: 147

    Article  CAS  Google Scholar 

  49. Wells H.G. and Osborne T.B. (1911)J. Infect. Dis. 8: 66.

    Google Scholar 

  50. Chase M.W. (1946) Proc. Soc. Bio. (N.Y.) 61: 257.

    CAS  Google Scholar 

  51. Thomas H.C. and Parrott D.M.V. (1974) Immunology 27: 631–639.

    PubMed  CAS  Google Scholar 

  52. Andre C., Heremans J.F., Vaerman J.P. and Cambiaso C.L. (1975) J. Exp. Med. 142: 1509.

    Article  PubMed  CAS  Google Scholar 

  53. Hanson D.G., Vaz N.M., Maa L.C.S., Hornbrook M.M., Lynch J.M. and Roy C.A. (1977) Int. Archs. Allergy Appl. Immun. 55: 526.

    Article  CAS  Google Scholar 

  54. Vaz N.M., Maia L.C.S., Hanson D.G. and Lynch J.M. (1977) J. Allergy Clin. Immunol. 60: 110–115.

    Article  PubMed  CAS  Google Scholar 

  55. Elson C.O., Heck J.A. and Strober W.E. (1979) J. Exp. Med. 149: 632.

    Article  PubMed  CAS  Google Scholar 

  56. Taylor B., NOrman A.P., Orgel H.A., Stokes C.R., Turner M.W. and Soothill J.F. (1973) Lancet 11: 111–113.

    Article  Google Scholar 

  57. Matthew D.J., Taylor B., Norman A.P., Turner M.W. and Soothill J.F. (1977) Lancet 1: 321.

    Article  PubMed  CAS  Google Scholar 

  58. Saarinen N.M., Kajasuari M., Backman A. and Siimes M. (1979) Lancet ii: 163.

    Google Scholar 

  59. Ordmann D. (1955) Int. Archs. Allergy. App. Immunol. 7: 10.

    Article  Google Scholar 

  60. Jarrett E.E.E. (1977) Lancet II 223.

    Article  Google Scholar 

  61. Bazin H. and Platteau B. (1976) Immunol. 30: 679.

    CAS  Google Scholar 

  62. Rothberg R.M. and Farr R.S. (1965) Paediatrics 35: 571.

    CAS  Google Scholar 

  63. Doe W.F., Booth C.C. and Brown D.L. (1973) Lancet 1: 402.

    Article  PubMed  CAS  Google Scholar 

  64. Mowbray J.F., Holborrow E.J., Hoffbrand A.V., Seah P.P. and Fry L. (1973) Lancet i: 400.

    Article  Google Scholar 

  65. Jewell D.P. and Maclennan I.C.M. (1973) Clin. Exp. Immunol. 14: 219.

    PubMed  CAS  Google Scholar 

  66. Asquith P., Thompson R.A. and Cooke W.T. (1969) Lancet ii: 129.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. St. Bartholomew’s Hospital, London, EC1, UK

    E. T. Swarbrick

Authors
  1. E. T. Swarbrick
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Child Health, University of London, London, England

    A. W. Wilkinson

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Plenum Press, New York

About this chapter

Cite this chapter

Swarbrick, E.T. (1981). The Handling of Ingested Antigens. In: Wilkinson, A.W. (eds) The Immunology of Infant Feeding. Ettore Majorana International Science Series, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4049-2_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4049-2_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4051-5

  • Online ISBN: 978-1-4684-4049-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation