Advertisement

The Handling of Ingested Antigens

  • E. T. Swarbrick
Part of the Ettore Majorana International Science Series book series (volume 8)

Abstract

The surface area of the intestine is one factor which makes it such an effective absorptive organ but it also permits considerable exposure to the enormous quantities of antigenic material within its lumen. The intestinal mucosa is widely thought to be impermeable to large molecular weight substances and food is generally absorbed in digested form. However, if the contents of the intestine act as antigens they must cross the external chemical and physical barriers in the lumen and gain access to the immune mechanisms within the body. That macromolecules are absorbed has been suspected since 1864 when Stokvis showed that after the ingestion of large amounts of egg proteins patients developed proteinuria and he suggested that some protein was being absorbed intact and secreted by the kidney.

Keywords

Ulcerative Colitis Coeliac Disease Antigen Absorption Dermatitis Herpetiformis Oral Immunisation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Morris I.G. (1968) in “Handbook of Physiology” vol. 2 p. 1491, Ed. Code C.F., Amer. Physiol. Soc.Google Scholar
  2. 2.
    Halliday R. (1955) Proc. R. Soc. Series B. Biol. Sci 143: 408.CrossRefGoogle Scholar
  3. 3.
    Morris I.G. (1963) Proc. R. Soc. London Series B. 157: 160.CrossRefGoogle Scholar
  4. 4.
    Jones E.A. and Waldman T. (1972) J. Clin. Invest. 51: 2915.Google Scholar
  5. 5.
    Halliday R. (1959) J. Endocrinol. 18: 56.PubMedCrossRefGoogle Scholar
  6. 6.
    Lippard V.W., Schloss O.M. and Johnson P.A. (1936) Am. J. Dis. Child. 5: 562.Google Scholar
  7. 7.
    Rothberg M. (1969) J. Paediat. 75: 391.CrossRefGoogle Scholar
  8. 8.
    Walker W.A., Cornell R., Davenport L.M. and Isselbacher K.J. (1972) J. Cell Biol. 54: 195.PubMedCrossRefGoogle Scholar
  9. 9.
    Clark S.L. (1959) Biophys. Biochem. Cytol. 5: 41.CrossRefGoogle Scholar
  10. 10.
    Brambell F.W.R. (1966) Lancet 2: 1087.PubMedCrossRefGoogle Scholar
  11. 11.
    Hillman H. and Sartory P. (1977) Perception 6: 667.PubMedCrossRefGoogle Scholar
  12. 12.
    Goldstein J.L., Anderson R.G.W. and Brown M.S. (1979) Nature 279: 679.PubMedCrossRefGoogle Scholar
  13. 13.
    Katayama K. and Fujita T. (1972) Biochem. Biophys. Acta 288: 181.CrossRefGoogle Scholar
  14. 14.
    Warshaw A.L., Walker A.W. and Isselbacher K.J. (1974) Gastroenterology 66: 987.PubMedGoogle Scholar
  15. 15.
    Jacob A.I., Goldberg P.K., Bloom N., Degenshein M.D. and Kozinn P.J. (1977) Gastroenterology 72: 1268.PubMedGoogle Scholar
  16. 16.
    Hemmings W.A. and Williams E.W. (1978) Gut 19: 715.PubMedCrossRefGoogle Scholar
  17. 17.
    Northrup R.S., Bienenstock J. and Tomasi T.B. (1970) J. Infect. Dis. 121: 137.PubMedCrossRefGoogle Scholar
  18. 18.
    Dupont H.L., Formal S.B. and Hornick R.S. (1971) N. Eng. J. Med. 285: 1.CrossRefGoogle Scholar
  19. 19.
    Lake A.M., Bloch K.J., Neutra M.R. and Walker W.A. (1979) J. Immunol. 122: 834.PubMedGoogle Scholar
  20. 20.
    Danforth E. and Moore R.O. (1959) Endocrinology 5: 118.CrossRefGoogle Scholar
  21. 21.
    Arloing F. and Langeran L. (1923) Compte. Rend. Soc. de Biol. 89: 1293 cited by Ratner & Gruehl (1934).Google Scholar
  22. 22.
    Makaroff (1923) Compte. Rend. Soc. de Biol. 89: 286 cited by Ratner & Gruehl (1934).Google Scholar
  23. 23.
    Hutinel (1908) Clinique, Paris, 3: 227 cited by Ratner & Gruehl (1934).Google Scholar
  24. 24.
    Schloss O.M. and Worthen T.W. (1916) Am. J. Dis. Child. II: 342.Google Scholar
  25. 25.
    Anderson A.F. and Schloss O.M. (1923) Am. J. Dis. Child. 26: 451.Google Scholar
  26. 26.
    Gruskay F.L. and Cooke R.E. (1955) Paediatrics 16: 763.Google Scholar
  27. 27.
    Taylor K.B., Turelove S.C., Thomson D.L. and Wright R. (1961) BMJ 11: 1727–1731.CrossRefGoogle Scholar
  28. 28.
    Kumar P.J., Ferguson A., Lancaster-Smith M. and Clark M.L. (1976) Scan. J. Gastroent. 11: 5.Google Scholar
  29. 29.
    Taylor K.B. and Truelove S.C. (1973) Lancet 11: 924.Google Scholar
  30. 30.
    Chandra R.K. (1975) Arch. Dis. Child. 50: 532.PubMedCrossRefGoogle Scholar
  31. 31.
    Smith M.W. and Burton K.E. (1972) Anim. Prod. 15: 139.CrossRefGoogle Scholar
  32. 32.
    Heremans J.F. (1969) “The Secretory Immunologic System” p. 309, Nat. Inst. Child Health and Human Dev., Bethesda.Google Scholar
  33. 33.
    Walker W.A., Isselbacher K.J. and Bloch K.J. (1972) Science 177: 608PubMedCrossRefGoogle Scholar
  34. 34.
    Andre C., Lambert R., Bazin H. and Heremans J.F. (1974) Eur. J. Immunol. 4: 701.PubMedCrossRefGoogle Scholar
  35. 35.
    Seifert J., Ring J., Steininger J. and Brendel W. (1977) Nutr. Metab. 21 (suppl. I): 256.PubMedGoogle Scholar
  36. 36.
    Walker W.A., and Bloch K.J. (1977) Gastroenterology (Abstract) A162/1185.Google Scholar
  37. 37.
    Swarbrick E.T., Stokes C.R. and Soothill J.F. (1979) Gut 20: 121–125.PubMedCrossRefGoogle Scholar
  38. 38.
    Walker W.A., Wu M., Isselbacher K.J. and Bloch K.J. (1975) J. Immunol. 115: 854.PubMedGoogle Scholar
  39. 39.
    Walker W.A., Wu M., Isselbacher K.J. and Bloch K.J. (1975) Gastroenterology 69: 1223.PubMedGoogle Scholar
  40. 40.
    Walker W.A., Wu M. and Bloch K.J. (1977) Science 197: 370.PubMedCrossRefGoogle Scholar
  41. 41.
    Brown W.R., Newcomb R.W. and Ishizaka K. (1970) J. Clin. Invest. 49: 1374.CrossRefGoogle Scholar
  42. 42.
    Steward M.W. (1971) Biochem. Biophys. Acta 236: 440.PubMedCrossRefGoogle Scholar
  43. 43.
    Stokes C.R., Soothill J.F. and Turner M.W. (1975) Nature 255: 745.PubMedCrossRefGoogle Scholar
  44. 44.
    Swarbrick E.T., Stokes C.R. and Soothill J.F. (1976) Gut 18: A945.Google Scholar
  45. 45.
    Paganelli R., Levinsky R.J., Brostoff J. and Wraith D.G. (1979) Lancet i: 1270.Google Scholar
  46. 46.
    British Medical Bulletin (May 1976) 32 (2).Google Scholar
  47. 47.
    Waksman B.H. (1977) Clin. Exp. Immunol. 28: 363–374.PubMedGoogle Scholar
  48. 48.
    Wells H.G. (1911) J. Infect. Dis. 9: 147CrossRefGoogle Scholar
  49. 49.
    Wells H.G. and Osborne T.B. (1911)J. Infect. Dis. 8: 66.Google Scholar
  50. 50.
    Chase M.W. (1946) Proc. Soc. Bio. (N.Y.) 61: 257.Google Scholar
  51. 51.
    Thomas H.C. and Parrott D.M.V. (1974) Immunology 27: 631–639.PubMedGoogle Scholar
  52. 52.
    Andre C., Heremans J.F., Vaerman J.P. and Cambiaso C.L. (1975) J. Exp. Med. 142: 1509.PubMedCrossRefGoogle Scholar
  53. 53.
    Hanson D.G., Vaz N.M., Maa L.C.S., Hornbrook M.M., Lynch J.M. and Roy C.A. (1977) Int. Archs. Allergy Appl. Immun. 55: 526.CrossRefGoogle Scholar
  54. 54.
    Vaz N.M., Maia L.C.S., Hanson D.G. and Lynch J.M. (1977) J. Allergy Clin. Immunol. 60: 110–115.PubMedCrossRefGoogle Scholar
  55. 55.
    Elson C.O., Heck J.A. and Strober W.E. (1979) J. Exp. Med. 149: 632.PubMedCrossRefGoogle Scholar
  56. 56.
    Taylor B., NOrman A.P., Orgel H.A., Stokes C.R., Turner M.W. and Soothill J.F. (1973) Lancet 11: 111–113.CrossRefGoogle Scholar
  57. 57.
    Matthew D.J., Taylor B., Norman A.P., Turner M.W. and Soothill J.F. (1977) Lancet 1: 321.PubMedCrossRefGoogle Scholar
  58. 58.
    Saarinen N.M., Kajasuari M., Backman A. and Siimes M. (1979) Lancet ii: 163.Google Scholar
  59. 59.
    Ordmann D. (1955) Int. Archs. Allergy. App. Immunol. 7: 10.CrossRefGoogle Scholar
  60. 60.
    Jarrett E.E.E. (1977) Lancet II 223.CrossRefGoogle Scholar
  61. 61.
    Bazin H. and Platteau B. (1976) Immunol. 30: 679.Google Scholar
  62. 62.
    Rothberg R.M. and Farr R.S. (1965) Paediatrics 35: 571.Google Scholar
  63. 63.
    Doe W.F., Booth C.C. and Brown D.L. (1973) Lancet 1: 402.PubMedCrossRefGoogle Scholar
  64. 64.
    Mowbray J.F., Holborrow E.J., Hoffbrand A.V., Seah P.P. and Fry L. (1973) Lancet i: 400.CrossRefGoogle Scholar
  65. 65.
    Jewell D.P. and Maclennan I.C.M. (1973) Clin. Exp. Immunol. 14: 219.PubMedGoogle Scholar
  66. 66.
    Asquith P., Thompson R.A. and Cooke W.T. (1969) Lancet ii: 129.Google Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • E. T. Swarbrick
    • 1
  1. 1.St. Bartholomew’s HospitalLondonUK

Personalised recommendations