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Estradiol and Progesterone Receptors in Human Endometrium

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The Endometrium

Abstract

In the last two decades, the development of saturation analysis methods has permitted specific and accurate measurement of circulating sex steroid hormones and documentation of their cyclic changes during the menstrual cycle. The large body of evidence accumulated over the past ten years indicates that hormones interact with a receptor system before triggering cellular responses. Hormone receptors were first identified and studied physiochemically for steroids, particularly estradiol, in the rat uterus. Once reliable measurements of hormone receptors became available in animal models, correlations between receptor concentrations and circulating levels of various hormones:were attempted. It was discovered that the concentration of receptor molecules is not fixed and varies with the physiological state of animals. Variations in the concentration and subcellular distribution of receptors were observed during the estrus cycle and could be mimicked in hormone-deprived animals by injecting estradiol and progesterone (Baulieu et al., 1975).

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Author notes

  1. Rodrigue Mortel

    Present address: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA

Authors and Affiliations

  1. Unité de Recherches sur le Métabolisme Moléculaire et la Physio-pathologie des Stéroides, L’institut National de la Sante et de la Recherche, Médicale, (U 33 INSERM) and ER 125 CNRS, 78 rue du Général Leclerc, 94270, Bicetre, France

    Paul Robel, Rodrigue Mortel & Etienne Emile Baulieu

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  1. Paul Robel
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  2. Rodrigue Mortel
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  3. Etienne Emile Baulieu
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Editors and Affiliations

  1. Foundation for Education and Research in Histo- and Cytopathology, Paris, France

    Jean de Brux

  2. M. S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania, USA

    Rodrigue Mortel

  3. University of Paris Val de Marne, Creteil, France

    Jean Pierre Gautray

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© 1981 Plenum Press, New York

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Robel, P., Mortel, R., Baulieu, E.E. (1981). Estradiol and Progesterone Receptors in Human Endometrium. In: de Brux, J., Mortel, R., Gautray, J.P. (eds) The Endometrium. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3977-9_4

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  • DOI: https://doi.org/10.1007/978-1-4684-3977-9_4

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