Estradiol and Progesterone Receptors in Human Endometrium

  • Paul Robel
  • Rodrigue Mortel
  • Etienne Emile Baulieu


In the last two decades, the development of saturation analysis methods has permitted specific and accurate measurement of circulating sex steroid hormones and documentation of their cyclic changes during the menstrual cycle. The large body of evidence accumulated over the past ten years indicates that hormones interact with a receptor system before triggering cellular responses. Hormone receptors were first identified and studied physiochemically for steroids, particularly estradiol, in the rat uterus. Once reliable measurements of hormone receptors became available in animal models, correlations between receptor concentrations and circulating levels of various hormones:were attempted. It was discovered that the concentration of receptor molecules is not fixed and varies with the physiological state of animals. Variations in the concentration and subcellular distribution of receptors were observed during the estrus cycle and could be mimicked in hormone-deprived animals by injecting estradiol and progesterone (Baulieu et al., 1975).


Progesterone Receptor Menstrual Cycle Endometrial Carcinoma Receptor Site Human Endometrium 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Paul Robel
    • 1
  • Rodrigue Mortel
    • 1
  • Etienne Emile Baulieu
    • 1
  1. 1.Unité de Recherches sur le Métabolisme Moléculaire et la Physio-pathologie des StéroidesL’institut National de la Sante et de la Recherche, Médicale, (U 33 INSERM) and ER 125 CNRSBicetreFrance

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