Selective Approaches to the Isolation and Standardization of Allergens

  • Brian A. Baldo
  • Steve Krilis
  • Antony Basten


Immediate immunoglobulin E (IgE)-mediated or type I (Coombs and Gell, 1975) hypersensitivity, sometimes referred to simply as “allergy,” is an extra ordinarily widespread disease, said to affect approximalely 10% of Caucasian populations al any one time. The form of immediate hypersensitivity most com-monly encountered is allergic rhinitis, although more severe hypersensitivity reactiuns are seen, for example, in allergic asthma and systemic anaphylaxis. The clinical signs of type I allergic reactions seen in man and other animals, namely, local inflammation and swelling, mucous production, airways obstruc-tion, and shock are produced by release of granule-associated vasoactive media-tors such as histamine, slow-reacting substance of anaphylaxis, and other active components (Austen et al., 1975; Goetz] and Austcn, 1977). These substances, at least some of which have pronounced effects on smooth muscle, secretions, vascular permeability, and Chemotaxis of eosinophils, are released from basophils and mast cclls following interaction of antigcn with complementary IgE antibodies fixed to the cell surfaccs (Ishizaka et al., 1970a). The IgE molecules (Ishizaka et al., 1966; Bennich and Johansson, 1967; Ishizaka 1975) function in this process by their capacity to bind both to the mast cell or basophil surface via the Fe piece of the antibodies (Stanworth et al., 1968; Ishizaka et al., 1970b) and to the complementary antigen via the antibody-combining Sites. Multivalent but not Univalent antigens initiate mediator release demonstrating that cross-linking of the cell-bound IgE is necessary to trigger the cells (Mossmann et at., 1974; Siraganian et al., 1975).


House Dust House Dust Mite Mite Allergen Allergen Extract Selective Approach 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

















N-actyl-neuraminic acid




Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Aas, K.. 1970, Arch. Dis. Child. 45:221.PubMedCrossRefGoogle Scholar
  2. Aas, K., 1975a, The Bronchial Provocation Test. Charles C Thomas, Springfield, 111.Google Scholar
  3. Aas, K., 1975b, Int. Arch. Allergy Appl. Immunol. 49:44.PubMedCrossRefGoogle Scholar
  4. Aas, K., 1975c, Dev. Biol. Stand. 29:341.PubMedGoogle Scholar
  5. Aas, K., and Belin, L., 1972, Acta Allergol. 27:439.Google Scholar
  6. Aas, K., and Elsayed, S., 1969, J. Allergy 44:333.PubMedCrossRefGoogle Scholar
  7. Aas, K., and Jebsen, J. W., 1967, Int. Arch. Allergy Appl. Immunol. 32:1.PubMedCrossRefGoogle Scholar
  8. Aas, K., and Johansson, S. G. O., 1971, J. Allergy 48:134.Google Scholar
  9. Aas, K., Backman, A., Belin, L., and Weeke, B., 1978, Allergy 33:130.PubMedCrossRefGoogle Scholar
  10. Adolphson, C., Goodfriend, L., and Gleich, G. J., 1978, J. Allergy Clin. Immunol. 62:197.PubMedCrossRefGoogle Scholar
  11. Allen, A. K., and Neuberger, A., 1973, Biochem. J. 135:307.PubMedGoogle Scholar
  12. Allen, A. K., Neuberger, A., and Sharon, N., 1973, Biochem. J. 131:155.PubMedGoogle Scholar
  13. Allen, A. K., Desai, N. N., and Neuberger, A., 1976, Biochem. J. 155:127.PubMedGoogle Scholar
  14. Ambler, J., and Orr, T. S. C., 1972, Immunochemistry 9:263.PubMedCrossRefGoogle Scholar
  15. Ambler, J., Miller, J. N., Johnson, P., and Orr, T. S. C., 1973, Immunochemistry 10:815.PubMedCrossRefGoogle Scholar
  16. Anderson, K. L., Wheat, R. W., and Conant, N. F., 1971, Appl. Microbiol. 22:294.PubMedGoogle Scholar
  17. Anton, A. H., and Sayre, D. F., 1969, J. Pharmacol. Exp. Ther. 166:285.PubMedGoogle Scholar
  18. Apold, J., Elsayed, S., Aukrust, L., and Bennich, H., 1919, I nt. Arch. Allergy Appl. Immunol. 58:337.CrossRefGoogle Scholar
  19. Arbesman, C. E., Wypych, J. I., and Reisman, R. E., 1977 Jnt. Arch. Allergy Appl. Immunol. 53:310.CrossRefGoogle Scholar
  20. Augustin, R., 1959, Immunology 2:148.PubMedGoogle Scholar
  21. Aukrust, L., 1979, Int. Arch. Allergy Appl. Immunol. 58:371.CrossRefGoogle Scholar
  22. Aukrust, L., Apold, J., Elsayed, S., and Aas, K., 1978, Int. Arch. Allergy Appl. Immunol. 57:253.PubMedCrossRefGoogle Scholar
  23. Austen, K. F., Lewis, R. A., Wasserman, S. I., and Goetzl, E. J., 1975, in: New Directions in Asthma (M. Stein, ed.), p. 187, American College of Chest Physicians, Park Ridge, Ill.Google Scholar
  24. Baenziger, J., and Kornfeld, S., 1974, J. Biol. Chem. 249:7270.PubMedGoogle Scholar
  25. Baer, H., Godfrey, H., Maloney, C. J., Norman, P. S. and Iichtenstein, L. M., 1970, J. Allergy 45:347.PubMedCrossRefGoogle Scholar
  26. Baer, H., Maloney, C. J., Norman, P. S., and Marsh, D. G., 1974, J. Allergy Clin. Immunol. 54:157.PubMedCrossRefGoogle Scholar
  27. Baldo, B. A., and Fletcher, T. C., 1973, Nature (London) 246:145.CrossRefGoogle Scholar
  28. Baldo, B. A. and Pepys, J., 1976, Gin. Allergy 6:563.Google Scholar
  29. Baldo, B. A., and Turner, K. J., 1915, Med. J. Aust. 2:871.Google Scholar
  30. Baldo, B. A., and Uhlenbruck, G., 1975a, FEBS Lett. 55:25.PubMedCrossRefGoogle Scholar
  31. Baldo, B. A., and Uhlenbruck, G., 1975b, in: Immunologie Phylogeny (W. M. Hildemann and H. A. Benedict, eds.), p. 3, Plenum Press, New York.Google Scholar
  32. Baldo, B. A., and Uhlenbruck, G., 1977a, Clin. Allergy 7:429.PubMedCrossRefGoogle Scholar
  33. Baldo, B. A., and Uhlenbruck, G., 1977b, Lancet 1:802.PubMedCrossRefGoogle Scholar
  34. Baldo, B. A., Turner, K. J., and Uhlenbruck, G., 1976, Experientia 32:641.PubMedCrossRefGoogle Scholar
  35. Baldo, B. A., Fletcher, T. C., and Pepys, J., 1977a, Immunology 32:831.PubMedGoogle Scholar
  36. Baldo, B. A., Uhlenbruck, G., and Steinhausen, G., 1977b, Comp. Biochem. Physiol. 56A:343.CrossRefGoogle Scholar
  37. Baldo, B. A., Fletcher, T. C., and Uhlenbruck, G., 1977c ,Naturwissenschaften 64:594.PubMedCrossRefGoogle Scholar
  38. Baldo, B. A., Sawyer, W. H., Stick, R. V., and Uhlenbruck, G., 1978, Biochem. J. 175:467.PubMedGoogle Scholar
  39. Baldo, B. A., Krilis, S., and Fletcher, T. C., 1979, Naturwissenschaften 66:623.PubMedCrossRefGoogle Scholar
  40. Baldo, B. A., Krilis, S., and Wrigley, C. W., 1980, Allergy 35:45.PubMedCrossRefGoogle Scholar
  41. Barker, S. A., Cruickshank, C. N. D., Morris, J. H., and Wood, S. R., 1962, Immunology 5:627.PubMedGoogle Scholar
  42. Barker, S. A., Cruickshank, C. N. D. and Holden, J. H., 1963, Biochim. Biophys. Acta 74:239.PubMedCrossRefGoogle Scholar
  43. Barsoum, G. S., and Gaddum, J. H., 1935, J. Physiol. 85:1.PubMedGoogle Scholar
  44. Bartnicki-Garcia, S., 1968, Annu. Rev. Microbiol. 22:87.PubMedCrossRefGoogle Scholar
  45. Beaven, M. A., Jacobsen, S, and Horakova, Z., 1972, Gin. Chim. Acta 37:91.CrossRefGoogle Scholar
  46. Belin, L., 1972a,Int. Arch. Allergy Appl. Immunol. 42:329.PubMedCrossRefGoogle Scholar
  47. Belin, L., 1972b, Int. Arch. Allergy Appl. Immunol. 42:300.PubMedCrossRefGoogle Scholar
  48. Bennich, H., and Johansson, S. G. O., 1967, in: Nobel Symposium ,Vol. 3 (J. Killander, ed.), p. 199, Almquist and Wiksell, Stockholm.Google Scholar
  49. Berrens, L., 1971, The Chemistry of Atopic Allergens, Monogr. Allergy 7.Google Scholar
  50. Bethell, G. S., Ayers, J. S., Hancock, W. S., and Hearn, M. T. W., 1979, J. Biol. Chem. 254:2572.PubMedGoogle Scholar
  51. Bezkorovainy, A., Springer, G. F., and Desai, P. R., 1971, Biochemistry 10:3761.PubMedCrossRefGoogle Scholar
  52. Blands, J., Diamant, B., Kallós, P., KaUós-Deffner, L., and Lowenstein, H., 1976, Int. Arch. Allergy Appl. Immunol. 52:392.PubMedCrossRefGoogle Scholar
  53. Blumenthal, M. N., Roitman, B., Carlson, G., and Fish, L., 1974, Biochem. Med. 11:312.PubMedCrossRefGoogle Scholar
  54. Bɸg-Hansen, T. C., 1973, Anal. Biochem. 56:480.PubMedCrossRefGoogle Scholar
  55. Bog-Hansen, T. C., and Brogren, C.-H., 1975, Scand. J. Immunol. 4(Suppl. 2):135.CrossRefGoogle Scholar
  56. Bog-Hansen, T. C., Prahl, P., and Lowenstein, H., 1978, J. Immunol. Methods 22:293.PubMedCrossRefGoogle Scholar
  57. Bonilla-Soto, O., Rose, N. R., and Arbesman, C. E., 1961, J. Allergy 32:246.CrossRefGoogle Scholar
  58. Booij-Noord, H., One, N. G. M., and De Vries, K., 1971, J. Allergy Gin. Immunol. 48:344CrossRefGoogle Scholar
  59. Boura, A. L. A., Mongar, J. L., and Schild, H. O., 1954, Br. J. Pharmacol. Chemother. 9:24.PubMedCrossRefGoogle Scholar
  60. Bourne, H. R., Lichtenstein, L. M., Henney, C. S., Melmon, K. L., Weinstein, Y.,and Shearer, G. M., 1974, Science 184:19.PubMedCrossRefGoogle Scholar
  61. Bowman, K. L., 1935, J. Allergy 7:39.CrossRefGoogle Scholar
  62. Bretting, H., and Kabat, E. A., 1976, Biochemistry 15:3228.PubMedCrossRefGoogle Scholar
  63. Brown, D. D., Tomchick, R., and Axelrod, J., 1959, J. Biol. Chem. 234:2948.PubMedGoogle Scholar
  64. Bruce, C., Weatherstone, R., Seaton, A., and Taylor, W. H., 1976, Thorax 31:724.PubMedCrossRefGoogle Scholar
  65. Brundish, D. E., and Baddiley, J., 1968, Biochem. J. 110:573.PubMedGoogle Scholar
  66. Bryant, D. H., Burns, W. M., and Lazarus, L., 1975, Gin. Allergy 5:145.Google Scholar
  67. Cambiaso, C. L., Goffinet, A., Vaerman, J. P., and Heremans, J. F., 1975, Immunochemistry 12:273.PubMedCrossRefGoogle Scholar
  68. Capron, A., Biguet, J,Van Ky, P. T., and Rorse, G., 1964, Presse Med. 72:3103.PubMedGoogle Scholar
  69. Carlini, E. A., and Green, J. P., 1963, Br. J. Pharmacol Chemother ,20:264.PubMedCrossRefGoogle Scholar
  70. Carlsen, S. D., Weeke, B., and Lowenstein, H., 1979, Allergy 34:155.PubMedCrossRefGoogle Scholar
  71. Carlson, D., 1968, J. Biol. Chem. 243:616.PubMedGoogle Scholar
  72. Ceska, M., Eriksson, R., and Varga, J. M., 1972, J. Allergy Gin. Immunol. 49:1.CrossRefGoogle Scholar
  73. Clarke, A. E., Anderson, R. L., and Stone, B. A., 1979, Phytochemistrv 18:521.CrossRefGoogle Scholar
  74. Clarke, H. G. M., and Freeman, T., 1967, in: Protides of the Biological Fluids ,Vol. 14 (H. Peeters, ed.), p. 519, Elsevier, Amsterdam.Google Scholar
  75. Claus, D. R., Osmand, A. P., and Gewurz, H., 1976, J. Lab. Gin. Med. 87:120.Google Scholar
  76. Conrad, D. H., and Froese, A., 1978, J. Immunol. 120:429.PubMedGoogle Scholar
  77. Coombs, R. R. A., and Gell, P. G. H., 1975, in: Ginical Aspects of Immunology (P. G. H. Gell and R. R. A. Coombs, eds.), p. 761, Blackwells, Oxford.Google Scholar
  78. Crandall, C. A., and Crandall, R. B., 1971, Exp. Parasitol. 30:426.PubMedCrossRefGoogle Scholar
  79. Delmotte, F., Kieda, C., and Monsigny, M., 1975, FEBS Lett. 53:324.PubMedCrossRefGoogle Scholar
  80. Donnelly, E. H., and Goldstein, I. J., 1970, Biochem. J. 118:679.PubMedGoogle Scholar
  81. Dubois, M., Gilles, K. A. ,Hamilton, J. K. Rebers, P. A., and Smith, F., 1956, Anal. Chem. 28:350.CrossRefGoogle Scholar
  82. Dulaney, J. T., 1979, Mol. Cell. Biochem. 21:43.Google Scholar
  83. Elsayed, S. M., and Aas, K., 1971a, Int. Arch. Allergy Appl. Immunol. 40:428.PubMedCrossRefGoogle Scholar
  84. Elsayed, S. M., and Aas, K., 1971b, J. Allergy 47:283.PubMedGoogle Scholar
  85. Elsayed, S., and Apold, J., 1977, Int. Arch. Allergy Appl. Immunol. 54:171.PubMedCrossRefGoogle Scholar
  86. Elsayed, S., Aas, K., Sletten, K., and Johansson, S. G. O., 1972, Immunochemistry 9:647.PubMedCrossRefGoogle Scholar
  87. Elsayed, S., Apold, J., Aas, K., and Bennich, H., 1976, Int. Arch. Allergy Appl. Immunol. 52:59.PubMedCrossRefGoogle Scholar
  88. Ersson, B., Aspberg, K., and Porath, J., 1913, Biochim. Biophys. Acta 310:446.Google Scholar
  89. Etzler, M. E. and Kabat, E. A., 1970, Biochemistry 9:869.PubMedCrossRefGoogle Scholar
  90. Fletcher, T. C., and Baldo, B. A. 1976, Experientia 32:1199.CrossRefGoogle Scholar
  91. Fletcher, T. C., White, A., and Baldo, B. A., 1980, Parasite Immunol. 2:237.PubMedCrossRefGoogle Scholar
  92. Foucard, T., Johansson, S. G. O., Bennich, H., and Berg, T., 1972, Int. Arch. Allergy Appl. Immunol. 43:360.PubMedCrossRefGoogle Scholar
  93. Gander, J. E., 1974, Annu. Rev. Microbiol. 28:103.PubMedCrossRefGoogle Scholar
  94. Gander, J. E., Jentoft, N. H., Drewes, L. R., and Rick, P. D., 1974, J. Biol. Chem. 249:2063.PubMedGoogle Scholar
  95. Gefter, M. L., Margulies, D. H., and Scharff, M. D., 1977, Somat. Cell Genet. 3:231.PubMedCrossRefGoogle Scholar
  96. Gillespie, E., 1975, Ann. N. Y. Acad. Sci. 253:771.PubMedCrossRefGoogle Scholar
  97. Gillespie, E., 1977, in: Comprehensive Immunology ,Vol. 3, Immunopharmacology (J. W. Hadden, R. G. Coffey, and F. Spreafico, eds.), p. 101, Plenum Press, New York.CrossRefGoogle Scholar
  98. Glaudemans, C. P. J., 1915, Adv. Carbohydr. Chem. Biochem. 31:313.CrossRefGoogle Scholar
  99. Gleich, G. J., Larson, J. B., Jones, R.T., and Baer, H., 1974, J. Allergy Clin. Immunol. 53:158.PubMedCrossRefGoogle Scholar
  100. Gleich, G. J., Leilerman, K. M., Jones, R. T., Hooton, M. L., and Baer, H., 1976, J. Allergy Clin. Immunol. 58:31.PubMedCrossRefGoogle Scholar
  101. Goetzl, E. J., and Austen, K. F., 1977, in: Comprehensive Immunology ,Vol. 3, Immunopharmacology (J. W. Hadden, R. G. Coffey, and F. Spreafico, eds.), p. 113, Plenum Press, New York.CrossRefGoogle Scholar
  102. Goldstein, I. J., and Hayes, C. E., 1978, Adv. Carbohydr. Chem. Biochem. 35:127.PubMedCrossRefGoogle Scholar
  103. Goldstein, I. J., Hammarström, S., and Sundblad, G., 1975, Biochim. Biophys. Acta 405:53.PubMedCrossRefGoogle Scholar
  104. Gorin, P. A. J., and Spencer, J. F. T., 1968, Adv. Carbohydr. Chem. 23:367.CrossRefGoogle Scholar
  105. Guilford, H., 1973, Chem. Soc. Rev. 2:249.CrossRefGoogle Scholar
  106. Hammarström, S., and Kabat, E. A., 1971, Biochemistry 8:2696.CrossRefGoogle Scholar
  107. Hammarström, S., Murphy, L. A., Goldstein, I. J. and Etzler, M. E., 1977, Biochemistry 16:2750.PubMedCrossRefGoogle Scholar
  108. Harris, W. G., 1973, Immunology 24:567PubMedGoogle Scholar
  109. Hayes, C. E., and Goldstein, I. J., 1974, J. Biol. Chem. 249:1904.PubMedGoogle Scholar
  110. Heidelberger, M., Gotschlich, E. C., and Higginbotham, J. D., 1972, Carbohydr. Res. 22:1.PubMedCrossRefGoogle Scholar
  111. Herbertson, S., Porath, J., and Colldahl, H., 1958, Acta Chem. Scand. 12:737.CrossRefGoogle Scholar
  112. Hoffman, D., 1977, J. Allergy Gin. Immunol. 59:364.CrossRefGoogle Scholar
  113. Hoffman, D., Shipman, W., and Babin, D., 1977, J. Allergy Gin. Immunol. 59:147.CrossRefGoogle Scholar
  114. Horakova, Z., Keiser, H. R., and Beaven, M. A., 1977, Gin. Chim. Acta 19:441.Google Scholar
  115. Hoejši, V., and Kocourek, J., 1974, Biochim. Biophys. Acta 336:329.CrossRefGoogle Scholar
  116. Hofejsi V., Ticha, M., and Kocourek, J., 1977, Biochim. Biophys. Acta 499:301.CrossRefGoogle Scholar
  117. Horejsi, V., Ticha, M., and Kocourek, J., 1979, Trends Biochem. Sci. 4:N6.CrossRefGoogle Scholar
  118. How, M. J., Withnall, M. T., and Cruiskshank, C. N. D., 1972, Carbohydr. Res. 25:341.PubMedCrossRefGoogle Scholar
  119. Huggins, K. G., Roitt, I. M., Brostoff, J., and Taylor, W. A., 1919, Int. Arch. Allergy Appl. Immunol. 58:241.CrossRefGoogle Scholar
  120. Hurlimann, J., Thorbecke, G. J., and Hochwald, G. M., 1966, J. Exp. Med. 123:365.PubMedCrossRefGoogle Scholar
  121. Hussain, R., Bradbury, S. M., and Strejan, G., 1973, J. Immunol. 111:260.PubMedGoogle Scholar
  122. Imber, W. E., 1977, J. Allergy Gin. Immunol. 60:47.CrossRefGoogle Scholar
  123. Irimura, T., and Osawa, T., 1972, Arch. Biochem. Biophys. 151:475.PubMedCrossRefGoogle Scholar
  124. Isersky, C., Taurog, J. T., Poy, G., and Metzger, H., 1978, J. Immunol. 121:549.PubMedGoogle Scholar
  125. Ishii, A., and Miyamoto, J., 1975, Jpn. J. Exp. Med. 45:263.PubMedGoogle Scholar
  126. Ishii, A., Noda, K., Nagai, Y., Ohsawa, T., Kato, I., Yokota, M., Nakamura, S., Matuhasi, T., and Sasa, M., 1973, Jpn. J. Exp. Med. 43:495.PubMedGoogle Scholar
  127. Ishizaki, H., 1970, Jpn. J. Dermatol. Ser. B 80:16.Google Scholar
  128. Ishizaka, K., 1975, in: The Antigens ,VoL 3 (M.Sela, ed.), p. 479, Academic Press, New York.Google Scholar
  129. Ishizaka, K., and Ishizaka, T., 1969, J. Immunol. 103:588.PubMedGoogle Scholar
  130. Ishizaka, K., Ishizaka, T., and Hornbrook, M. M., 1966, J. Immunol. 97:840.PubMedGoogle Scholar
  131. Ishizaka, T., Ishizaka, K., Orange, R. P., and Austen, K. F., 1970a, J. Immunol. 104:335.PubMedGoogle Scholar
  132. Ishizaka, K., Ishizaka, T., and Lee, E. H., 1970b, Immunochemistry 7:687.PubMedCrossRefGoogle Scholar
  133. Joubert, L., and Thomas, G. B., 1970, J. Gin. Pharmacol. 10:165.Google Scholar
  134. Kabasawa, Y., Ishii, A., Murata, H., and Takoaka, M., 1916, Acta Allergol. 31:442.CrossRefGoogle Scholar
  135. Kabat, E. A., 1961, in: Kabat and Mayer’s Experimental Immunochemistry, 2nd ed., pp. 22 and 405, Charles C Thomas, Springfield, Ill.Google Scholar
  136. Kabat, E. A., 1976, Structural Concepts in Immunology and Immunochemistry ,2nd ed., Holt, Rinehart and Winston, New York.Google Scholar
  137. Kabat, E. A., Turino, G. M., Tarrow, A. B, and Maurer, P. H., 1957,7. Gin.Invest. 36:1160.CrossRefGoogle Scholar
  138. Kaliner, M., and Austen, K. F., 1973, J. Exp. Med. 138:1077.PubMedCrossRefGoogle Scholar
  139. Kennedy, J. F., 1973, Chem. Soc. Rev. 2:355.CrossRefGoogle Scholar
  140. Kerckaert, J.-P, Bayard, B., and Biserte, G., 1979, Biochim. Biophys. Acta 576:99.PubMedCrossRefGoogle Scholar
  141. King, T. P., 1916, Adv. Immunol. 23:77.CrossRefGoogle Scholar
  142. King, T. P., Norman, P. S., and Connell, J. T., 1964, Biochemistry 3:458.PubMedCrossRefGoogle Scholar
  143. King, T. P., Norman, P. S., and Lichtenstein, L. M., 1967a, Biochemistry 6:1992.PubMedCrossRefGoogle Scholar
  144. King, T. P., Norman, P. S., and Lichtenstein, L. M., 1967b, Ann. Allergy 25:541.PubMedGoogle Scholar
  145. King, T. P., Sobotka, A. K., Kochoumian, L., and Lichtenstein, L. M., 1976, Arch. Biochem. Biophys. 172:661.PubMedCrossRefGoogle Scholar
  146. King, T. P., Sobotka, A. K., Alagon, A., Kochoumian, L., and Lichtenstein, L. M., 1978, Bioch emistry 17:5165.CrossRefGoogle Scholar
  147. Kishimoto, T., Shigemoto, S., Watanabe,T., and Yamamura, Y., 1919, J. Immunol. 123:1039.Google Scholar
  148. Kobayashi, Y., and Maudsley, D. V., 1972, Anal Biochem. 48:85.CrossRefGoogle Scholar
  149. Köhler, G., and Milstein, C., 1975, Nature (London) 256:495.CrossRefGoogle Scholar
  150. Köhler, G., and Milstein, C., 1976, Eur. J. Immunol. 6:511.PubMedCrossRefGoogle Scholar
  151. Köhler, G., Howe, S. C., and Milstein, C., 1976, Eur. J. Immunol. 6:292.PubMedCrossRefGoogle Scholar
  152. Kornfeld, R., and Kornfeld, S., 1916, Annu. Rev. Biochem. 45:217.CrossRefGoogle Scholar
  153. Kremzner, L. T., and Pfeiffer, C. C., 1966, Biochem. Pharmacol. 15:197.PubMedCrossRefGoogle Scholar
  154. Kristiansen, T., 1974, in: Methods of Enzymology ,Vol. XXXIV, Affinity Techniques. Enzyme Purification ,Part B (W. B. Jakoby and M. Wilchek, eds.), p. 331, Academic Press, New York.Google Scholar
  155. Kulczycki, A., Jr., Isersky, C., and Metzger, H., 1974, J. Exp. Med. 139:600.PubMedCrossRefGoogle Scholar
  156. Kümel, G., Daus, H., and Mauch, H., 1979, J. Chromatogr. 172:221.PubMedCrossRefGoogle Scholar
  157. Larm, O., and Scholander, E., 1977, Carbohydr. Res. 58:249.PubMedCrossRefGoogle Scholar
  158. Lauren, C.-B., 1965, Anal. Biochem. 10:358.CrossRefGoogle Scholar
  159. Leiferman, K. M., and Gleich, G. J., 1976, J. Allergy Gin. Immunol. 58:129.CrossRefGoogle Scholar
  160. Leiferman, K. M., Gleich, G. J., and Jones, R. T., 1976, J. Allergy Gin. Immunol. 58:140.CrossRefGoogle Scholar
  161. Leon, M. A., 1967, Science 158:1325.PubMedCrossRefGoogle Scholar
  162. Leon, M. A., and Young, N. M., 1911, Biochemistry 10:1424.CrossRefGoogle Scholar
  163. Levy, D. A., and Widra, M., 1973, J. Lab. Gin. Med. 81:291.Google Scholar
  164. Lichtenstein, L. M., and Margolis, S., 1968, Science 161:902.PubMedCrossRefGoogle Scholar
  165. Lichtenstein, L. M., King, T. P., and Osier, A. G., 1966, J. Allergy 38:174.PubMedCrossRefGoogle Scholar
  166. Lichtenstein, L. M., Roebber, M., and Goodfriend, L., 1973, J. Allergy Gin. Immunol. 51:285.CrossRefGoogle Scholar
  167. Lindahl, U., and Höök, M., 1978, Annu. Rev. Biochem. 47:385.PubMedCrossRefGoogle Scholar
  168. Lis, H., and Sharon, N., 1977, in: The Antigens ,Vol. 4 (M. Sela, ed.), p. 429, Academic Press, New York.Google Scholar
  169. Lloyd, K. O., 1970a, Arch. Biochem. Biophys. 137:460.PubMedCrossRefGoogle Scholar
  170. Lloyd, K. O., 1970b, FEBS Lett. 11:91.PubMedCrossRefGoogle Scholar
  171. Lloyd, K. O., 1976, in: International Review of Science, Organic Chemistry Series Two, Vol. 7, Carbohydrates (G. O. Aspinall, ed.), p. 251, Butterworths, London.Google Scholar
  172. Lloyd, K. O., and Bitoon, M. A., 1971, J. Immunol. 107:663.PubMedGoogle Scholar
  173. Longbottom, J. L., and Pepys, J., 1964, J. Pathol. Bacteriol. 88:141PubMedCrossRefGoogle Scholar
  174. Lotan, R., Siegelman, H. W., Iis, H., and Sharon, N., 1974, J. Biol. Chem. 249:1219.PubMedGoogle Scholar
  175. Lotan, R., Skutelsky, E., Danon, D., and Sharon, N., 1975, J. Biol. Chem. 250:8487.Google Scholar
  176. Lowe, C. R., and Dean, P. D. G., 1991 A, Affinity Chromatography ,Wiley, New York.Google Scholar
  177. Lowenstein, H., 1978, Allergy 33:30.PubMedCrossRefGoogle Scholar
  178. Lowenstein, H., Nielsen, L., and Weeke, B., 1974, Acta Allergol. 29:418.CrossRefGoogle Scholar
  179. Lowenstein, H., Markussen, B., and Weeke, B., 1976a, Int. Arch. Allergy Appl. Immunol. 51:38.PubMedCrossRefGoogle Scholar
  180. Lowenstein, H., Markussen, B., and Weeke, B., 1976b, Int. Arch. Allergy Appl. Immunol. 51:48.CrossRefGoogle Scholar
  181. Lowenstein, H., Aukrust, L., and Gravesen, S., 1977, Int. Arch. Allergy Appl. Immunol. 51:1.Google Scholar
  182. Lowry, O. H., Graham, H. T., Harris, F. B., Priebat, M. K., Marks, A. R., and Bregman, R. U., 1954, J. Pharmacol. Exp. Ther. 112:116.PubMedGoogle Scholar
  183. Marchalonis, J. J., and Edelman, G. M., 1968, J. Mol. Biol. 32:453.CrossRefGoogle Scholar
  184. Margulies, D. H., Kuehl, W. M., and Scharff, M. D., 1976, Cell 8:405.PubMedCrossRefGoogle Scholar
  185. Marsh, D. G., 1975, in: The Antigens ,Vol. 3 (M. Sela, ed.), p. 271, Academic Press, New York.Google Scholar
  186. Marsh, D. G., Milner, F. H., and Johnson, P., 1966, Int. Arch. Allergy 29:39.CrossRefGoogle Scholar
  187. Marshall, R. D., 1972, Annu. Rev. Biochem. 41:673.PubMedCrossRefGoogle Scholar
  188. May, C. D., Lyman, M., Alberto, R., and Chen, J., 1970, J. Allergy 46:12.PubMedCrossRefGoogle Scholar
  189. McMichael, A., and McDevitt, H. O., 1977, Prog. Med. Genet. 2:39.PubMedGoogle Scholar
  190. Melchers, F., Potter, M., and Warner, N., eds., 1978, Current Topics in Microbiology and Immunology ,Vol. 81, Lymphocyte Hybridomas ,Springer, Berlin.Google Scholar
  191. Melling, J., 1991 A, Process Biochem. 9:7.Google Scholar
  192. Metzger, H., 1977, in: Receptors and Recognition (P. Cuatrecasas and M. F. Greaves, eds.), Series A, Vol. 4, p. 73, Chapman and Hall, London.Google Scholar
  193. Michaelson, I. A., 1967, Eur. J. Pharmacol. 1:378.PubMedCrossRefGoogle Scholar
  194. Montreuil, J., 1975, Pure Appl. Chem. 42:431.CrossRefGoogle Scholar
  195. Mossmann, H., Meyer-Delius, M., Votisch, U., Kickhofen, B., and Hammer, D. K., 1974, J. Exp. Med. 140:1468.PubMedCrossRefGoogle Scholar
  196. Newman, S. A., Rossi, G., and Metzger, H., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:869.PubMedCrossRefGoogle Scholar
  197. Nicholson, G. L., 1974, Int. Rev. Cytol. 39:89.CrossRefGoogle Scholar
  198. Nicholson, G. L., Blaustein, J., and Etzler, M. E., 1974, Biochemistry 13:196.CrossRefGoogle Scholar
  199. Nielsen, L., Lowenstein, H., and Weeke, B., 1914, Acta Allergol. 29:385.CrossRefGoogle Scholar
  200. Norman, P. S., and Iichtenstein, L. M., 1973, J. Allergy din. Immunol. 52:94.CrossRefGoogle Scholar
  201. Olsnes, S., Saltvedt, E., and Pihl, A., 1974, J. Biol. Chem. 249:803.PubMedGoogle Scholar
  202. Oppenheim, J. D., Nachbar, M. S., Salton, M. R. J., and Aull, F., 1974, Biochem. Biophys. Res. Commun. 58:1127.PubMedCrossRefGoogle Scholar
  203. Osawa, T., and Matsumoto, I., 1972, Meth. Enzymol. 28(Part B):323.CrossRefGoogle Scholar
  204. Owen, P., Oppenheim, J. D., Nachbar, M. S., and Kessler, R. E., 1977, Anal. Biochem. 80:446.PubMedCrossRefGoogle Scholar
  205. Pauli, B. R., Yunginger, J. W., and Gleich, G. J., 1977, J. Allergy Gin. Immunol. 59:334.CrossRefGoogle Scholar
  206. Pepys, J., 1975, in: Clinical Aspects of Immunology (P. G. H. Gell and R. R. A. Coombs, eds.), p. 55, Blackwells, Oxford.Google Scholar
  207. Pepys, J., 1976, in: Bronchial Asthma Mechanisms and Therapeutics (E. B. Weiss and M. S. Segal, eds.), p. 231, Little, Brown, Boston.Google Scholar
  208. Pepys, J., and Hutchcroft, B. J., 1915, Am. Rev. Resp. Dis. 112:829.Google Scholar
  209. Pepys, J., and Longbottom, J. L., 1971, Int. Arch. Allergy Appl. Immunol. 41:219.PubMedCrossRefGoogle Scholar
  210. Pepys, J., Pickering, C. A., and Loudon, H. W. G., 1972, Qin. Allergy 2:189.Google Scholar
  211. Pereira, M. E. A., and Kabat, E. A., 1914, Biochemistry 13:3184.CrossRefGoogle Scholar
  212. Pereira, M. E. A., Kabat, E. A., and Sharon, N., 1974, Carbohydr. Res. 37:89.PubMedCrossRefGoogle Scholar
  213. Pereiia, M. E. A., Kabat, E. A., Lotan, R., and Sharon, N., 1976, Carbohydr. Res. 51:107.CrossRefGoogle Scholar
  214. Péry, P., Petit, A., Poulain, J., and Luffau, G., 1974, Eur. J. Immunol. 4:637.PubMedCrossRefGoogle Scholar
  215. Porath, J., Axen, R., and Ernback, S., 1967.Nature (London) 215:1491.CrossRefGoogle Scholar
  216. Poretz, R. D., Riss, H., Timberlake, J. W., and Chien, S. M., 1974, Biochemistry 13:250.PubMedCrossRefGoogle Scholar
  217. Porter, M. C., and Michaels, A. S., 1971, Chem. Tech. 1:440.Google Scholar
  218. Potter, M., 1970, Fed. Proc. 29:85.PubMedGoogle Scholar
  219. Potter, M., 1972,Physiol. Rev. 52:690.Google Scholar
  220. Potter, M., l977, Adv. Immunol. 25:141.PubMedCrossRefGoogle Scholar
  221. Prahl, P., Weeke, B., and Lowenstein, H., 1978, Allergy 33:241.PubMedCrossRefGoogle Scholar
  222. Raizada, M. K., Schutzbach, J. S.,and Ankel, H., 1975, J. Biol. Chem. 250:3310.PubMedGoogle Scholar
  223. Rapin, A. M. C., and Burger, M. M., 1974, Adv. Cancer Res. 29:1.CrossRefGoogle Scholar
  224. Rauvala, H., and Finne, J., 1979, FEBS Lett. 97:1.PubMedCrossRefGoogle Scholar
  225. Reddy, P. M., Nagaya, H., Pascual, H. C., Lee, S. K., Gupta, S., Lauridsen, J. I., and Jerome,D. C1978,J. Allergy Gin. Immunol. 61:36.CrossRefGoogle Scholar
  226. Reiss, E., and Lehmann, P. F., 1979, Infect. Immun. 25:357.PubMedGoogle Scholar
  227. Reiss, E., Mitchell, W. O., Stone, S. H., and Hasenclever, H. F., 1974, Infeet. Immun. 10:802.Google Scholar
  228. Rosenthal, S. M., and Tabor, H., 1948, J. Pharmacol. Exp. Ther. 92:425.PubMedGoogle Scholar
  229. Sarsfield, J. K., 1974, Arch. Dis. Child. 49:711.PubMedCrossRefGoogle Scholar
  230. Schanfield, M. S., 1978, in: Basic and Clinical Immunology (H. H. Fudenberg, D. P. Stites, J. L. CaldweU, and J. V. Wells, eds.), p. 59, Lange, Los Altos, Calif.Google Scholar
  231. Schild, H. O., Hawkins, D. F., Mongar, J. L., and Herxheimer, H., 1951, Lancet ii:376.CrossRefGoogle Scholar
  232. Segal, D. M., Taurog, J. D., and Metzger, H., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:2993.PubMedCrossRefGoogle Scholar
  233. Shaff, R. E., and Beaven, M. A., 1979, Anal. Biochem. 94:425.PubMedCrossRefGoogle Scholar
  234. Shankar Iyer, P. N., Wilkinson, K. D., and Goldstein, I. J., 1976, Arch. Biochem. Biophys. 177:330.CrossRefGoogle Scholar
  235. Shier, W. T., Lin, Y., De Vries, A. L., 1975, FEBS Lett. 54:135.PubMedCrossRefGoogle Scholar
  236. Shore, P. A., Burkhalter, A., and Cohn, V. H., Jr., 1959, J. Pharmacol. Exp. Ther. 127:182.PubMedGoogle Scholar
  237. Siraganian, R. P., 1974, Anal. Biochem. 57:383.PubMedCrossRefGoogle Scholar
  238. Siraganian, R. P., and Brodsky, M. J., 1976, J. Allergy Clin. Immunol. 57:525.PubMedCrossRefGoogle Scholar
  239. Siraganian, R. P., and Sandberg, A. L., 1979, J. Allergy Clin. Immunol. 63:435.PubMedCrossRefGoogle Scholar
  240. Siraganian, R. P., Hook, W. A., and Levine, B. B., 1915, Immunochemistry 12:149.CrossRefGoogle Scholar
  241. Smith, J. A., Hurrell, J. G. R., and Leach, S. J., 1978, Anal. Biochem. 87:299.PubMedCrossRefGoogle Scholar
  242. Snyder, S. H., Baldessarini, R. J., and Axelrod, J., 1966, J. Pharmacol. Exp. Ther. 153:544.PubMedGoogle Scholar
  243. Sobotka, A. K., Franklin, R. M., Adkinson, N. F., Valentine, M., Baer, H., and Lichtenstein, L. M., 1976, J. Allergy Clin. Immunol. 57:29.PubMedCrossRefGoogle Scholar
  244. Spiro, R. G., 1973, in: Advances in Protein Chemistry ,Vol. 27 (C. B. Aníìnsen, J. T. Edsall, and F. M. Richards, eds.), p. 349, Academic Press, New York.Google Scholar
  245. Springer, G. F., and Desai, P. R., 1971, Biochemistry 10:3749.PubMedCrossRefGoogle Scholar
  246. Squire, J. R., 1952, Br. Med. J. 1:1.PubMedCrossRefGoogle Scholar
  247. Stanworth, D. R., 1973, Immediate Hypersensitivity: The Molecular Basis of the Allergic Response ,North Holland, Amsterdam.Google Scholar
  248. Stanworth, D. R., Humphrey, J. H., Bennich, H., and Johansson, S.G.O., 1968, Lancet ii:17.CrossRefGoogle Scholar
  249. Stenius, B., Wide, L., Seymour, W. M., Holford-Strevens, V., and Pepys, J., 1971, Gin. Allergy 1:37.Google Scholar
  250. Sternberger, L. A., Feinberg, A. R., Feinberg, S. M., Clarke, M., Benaim, C., and Warren, S.A., 1956, J. Allergy 27:16.PubMedCrossRefGoogle Scholar
  251. Sundberg, L., and Porath, J., 1974, J. Chromatogr. 90:87.PubMedCrossRefGoogle Scholar
  252. Tada, T., 1974, Prog. Allergy 19:122.Google Scholar
  253. Taylor, K. M., and Snyder, S. H., 1972, J. Neurochem. 19:1343.PubMedCrossRefGoogle Scholar
  254. Taylor, K. M., Krilis, S., and Baldo, B. A., 1980, Int. Arch. Allergy Appl. Immunol. 61:19.PubMedCrossRefGoogle Scholar
  255. Tichá, M., Entlicher, G., Kõstif, and Kocourek, J., 1970, Biochim. Biophys. Acta 221:282.PubMedCrossRefGoogle Scholar
  256. Tfflett, W. S., and Francis, R., Jr., 1930, J. Exp. Med. 52:561.CrossRefGoogle Scholar
  257. Tillett, W. S., Goebel, W. F., and Avery, O. T., 1930, J. Exp. Med. 52:895.PubMedCrossRefGoogle Scholar
  258. Van Wauwe, J. P., Loontiens, F. G., and De Bruyne, C. K., 1975, Biochim. Biophys. Acta 379:456.PubMedCrossRefGoogle Scholar
  259. Volanakis, J. E., and Kaplan, M. H., 1971, Proc. Soc. Exp. Biol. Med. 136:612.PubMedGoogle Scholar
  260. Voorhorst, R., Spieksma-Boezeman, M. I. A., and Spieksma, F. T. M., 1964, Allerg. Asthma 10:329.PubMedGoogle Scholar
  261. Vugman, I., and Rocha e Silva, M., 1966, in: Handbook of Experimental Pharmacology (O. Eichler and A. Farah, eds.), Vol. 18, Part 1, p. 81, Springer Verlag, New York.Google Scholar
  262. Wang, J. L., Becker, J. W., Reeke, G. N., Jr., and Edelman, G. M., 1974, J. Mol Biol. 88:259.PubMedCrossRefGoogle Scholar
  263. Watkins, W. M., 1974, Biochem. Soc. Symp. 40:125.PubMedGoogle Scholar
  264. Weeke, B., 1913, Scand. J. Immunol. 2(Suppl. l):47.Google Scholar
  265. Weeke, B., and Lowenstein, H., 1973, Scand. J. Immunol. 2(Suppl. 1):149.CrossRefGoogle Scholar
  266. Wei, C. H., Koh, C., Pfuderer, P., and Einstein, J. R., 1975, J. Biol. Chem. 250:4790.PubMedGoogle Scholar
  267. Wharton, G. W., 1976, J. Med. Entomol. 12:577.PubMedGoogle Scholar
  268. White, A., Fletcher, T. C., Towler, C. M., and Baldo, B. A., 1978, Comp. Biochem. Physiol. 61C:331.Google Scholar
  269. Wide, L., 1973, Clin. Allergy 3(Suppl.):583.CrossRefGoogle Scholar
  270. Wide, L., Bennich, H., and Johansson, S. G. O., 1967, Lancet ii:1105.CrossRefGoogle Scholar
  271. Woolcock, A., 1976, Amt. N. Z. J. Med. 6:158.CrossRefGoogle Scholar
  272. Woolcock, A., 1976, Aust. N.Z. J. Med. 6:158.PubMedCrossRefGoogle Scholar
  273. Wright, G. T. L., and Derrick, E. H., 1975,Med. J. Aust. 1:375.PubMedGoogle Scholar
  274. Yman, L., Ponterius, G. and Brandt, R., 1975, Dev. Biol Stand. 29:151–PubMedGoogle Scholar
  275. Young, N. M., Leon, M. A., Takahashi, T., Howard, I. K., and Sage, H. J., 1971, J. Biol.Chem. 246:1596.PubMedGoogle Scholar
  276. Yunginger, J. W., Jones, R. T., and Gleich, G. J., 1976,J. Allergy Clin. Immunol. 58:405.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Brian A. Baldo
    • 1
  • Steve Krilis
    • 1
    • 2
  • Antony Basten
    • 2
  1. 1.Roche Research Institute of Marine PharmacologyDee WhyAustralia
  2. 2.Immunology Unit Department of BacteriologyUniversity of SydneySydneyAustralia

Personalised recommendations