Summary and Perspective: Relevance to Human Health Hazard Assessment

  • Charles H. Langley
Part of the Basic Life Sciences book series (BLSC, volume 15)


In this session Drs. German, Paterson, and Swift presented their thoughts and research results on human genetic variation that is known or suspected to involve DNA repair and/or mutagen sensitivity. Their discussion brought out some of the salient issues in this area: (1) the difficulties in identifying mutant phenotypes that might involve disturbances in the function of the genetic machinery, (2) relationships between cellular and molecular phenomena and possible associations with phenotypes and environmental interactions, and (3) the possibility of increased cancer risk in heterozygotes.


Tuberous Sclerosis Ataxia Telangiectasia Xeroderma Pigmentosum Ataxia Telangiectasia Increase Cancer Risk 
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    German, J., Chromosome-breakage syndromes: different genes, different treatments, different cancers, This volume, p. 429.Google Scholar
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    Paterson, M. C., and P. J. Smith, Ataxia telangiectasia: an inherited human disorder involving hypersensitivity to ionizing radiation and related DNA-damaging chemicals, Ann. Rev. Genetics, 13 (1979) 291–318.CrossRefGoogle Scholar
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    Simmons, J., and J. C. Crow, Mutations affecting fitness in Drosophila populations, Ann. Rev. Genetics, 11 (1978) 49–78.CrossRefGoogle Scholar
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    Swift, M., L. Sholman, M. Perry, and C. Chase, Malignant neoplasms in families of patients with ataxia-telangiectasia, Cancer Res., 36 (1976) 209–215.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Charles H. Langley
    • 1
  1. 1.National Institute of Environmental Health SciencesResearch Triangle ParkUSA

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