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Summary and Perspective: Relevance to Human Health Hazard Assessment

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DNA Repair and Mutagenesis in Eukaryotes

Part of the book series: Basic Life Sciences ((BLSC,volume 15))

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Abstract

In this session Drs. German, Paterson, and Swift presented their thoughts and research results on human genetic variation that is known or suspected to involve DNA repair and/or mutagen sensitivity. Their discussion brought out some of the salient issues in this area: (1) the difficulties in identifying mutant phenotypes that might involve disturbances in the function of the genetic machinery, (2) relationships between cellular and molecular phenomena and possible associations with phenotypes and environmental interactions, and (3) the possibility of increased cancer risk in heterozygotes.

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References

  1. German, J., Chromosome-breakage syndromes: different genes, different treatments, different cancers, This volume, p. 429.

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  2. Paterson, M. C., and P. J. Smith, Ataxia telangiectasia: an inherited human disorder involving hypersensitivity to ionizing radiation and related DNA-damaging chemicals, Ann. Rev. Genetics, 13 (1979) 291–318.

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Author information

Authors and Affiliations

  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27709, USA

    Charles H. Langley

Authors
  1. Charles H. Langley
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Editor information

Editors and Affiliations

  1. Oak Ridge National Laboratories, Oak Ridge, Tennessee, USA

    W. M. Generoso

  2. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    M. D. Shelby  & F. J. de Serres  & 

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© 1980 Plenum Press, New York

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Langley, C.H. (1980). Summary and Perspective: Relevance to Human Health Hazard Assessment. In: Generoso, W.M., Shelby, M.D., de Serres, F.J. (eds) DNA Repair and Mutagenesis in Eukaryotes. Basic Life Sciences, vol 15. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3842-0_31

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  • DOI: https://doi.org/10.1007/978-1-4684-3842-0_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3844-4

  • Online ISBN: 978-1-4684-3842-0

  • eBook Packages: Springer Book Archive

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