Summary and Perspective: Relevance to Human Health Hazard Assessment
In this session Drs. German, Paterson, and Swift presented their thoughts and research results on human genetic variation that is known or suspected to involve DNA repair and/or mutagen sensitivity. Their discussion brought out some of the salient issues in this area: (1) the difficulties in identifying mutant phenotypes that might involve disturbances in the function of the genetic machinery, (2) relationships between cellular and molecular phenomena and possible associations with phenotypes and environmental interactions, and (3) the possibility of increased cancer risk in heterozygotes.
KeywordsTuberous Sclerosis Ataxia Telangiectasia Xeroderma Pigmentosum Ataxia Telangiectasia Increase Cancer Risk
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- 1.German, J., Chromosome-breakage syndromes: different genes, different treatments, different cancers, This volume, p. 429.Google Scholar