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DNA Repair and Mutagenesis in Eukaryotes

  • W. M. Generoso
  • M. D. Shelby
  • F. J. de Serres

Part of the Basic Life Sciences book series (BLSC, volume 15)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Reviews

    1. B. Strauss, K. N. Ayres, K. Bose, P. Moore, R. Sklar, K. Tatsumi
      Pages 25-43
    2. R. B. Setlow
      Pages 45-54
  3. Lower Eukaryotes

    1. Neurospora crassa

      1. Alice L. Schroeder, Loree D. Olson
        Pages 55-62
      2. M. J. Fraser, T. Y.-K. Chow, E. Käfer
        Pages 63-74
    2. Saccharomyces cerevisiae

  4. Drosophila

    1. P. Dennis Smith, Ronald D. Snyder, Ruth L. Dusenbery
      Pages 175-188
    2. Bruce S. Baker, Maurizio Gatti, Adelaide T. C. Carpenter, Sergio Pimpinelli, David A. Smith
      Pages 189-208
    3. James B. Boyd, Paul V. Harris, Christopher J. Osgood, Karen E. Smith
      Pages 209-221
    4. F. E. Würgler, U. Graf
      Pages 223-240
  5. Mammalian Somatic Cells

  6. Mouse Germ Cells

  7. Relevance to Human Health Hazard Assessment

  8. Back Matter
    Pages 445-458

About this book

Introduction

Not many years ago most discussion of mutation induction by physical and chemical agents concentrated on the initial lesions induced in the DNA with the implicit assumption that once the lesions were made they were converted almost automatically to mutations by relatively simple processes associated with DNA replication. The discovery of a variety of enzymatic processes that can repair these lesions, the great increase in our understanding of the molecular steps involved in repair, replication, and recombination, and the increasing availability of cells with genetic defects in these pro­ cesses have led to the realization that mutation induction is a far more complex process than we originally thought. Repair systems can remove lesions before they can be converted to mutation, they can also convert initial lesions to secondary ones that are them­ selves mutagenic, and they can remove potentially lethal lesions at the expense of making mutations. The error-avoiding systems asso­ ciated with replication are themselves complex and may be caused to make mistakes in various ways. These different pathways for mutation production and mutation avoidance are still being worked out in prokaryotes and are less well understood in eukaryotes. This symposium shows, however, that very encouraging progress has been made in the last several years, and the progress is now accelerating.

Keywords

DNA cells chromosome mutagen mutagenesis mutation production

Editors and affiliations

  • W. M. Generoso
    • 1
  • M. D. Shelby
    • 2
  • F. J. de Serres
    • 2
  1. 1.Oak Ridge National LaboratoriesOak RidgeUSA
  2. 2.National Institute of Environmental Health SciencesResearch Triangle ParkUSA

Bibliographic information