Adaptive Alterations in Receptor Mediated Processes and their Implications for Some Mental Disorders

  • Kenneth A. Bonnet
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 116)


The locus and mechanisms of long-lasting adaptation in neural systems have been the subject of intensive re search efforts for many years. Prominent among early efforts was the demonstration of an increased sensitivity to acetylcholine in denervated skeletal muscle (CANNON and ROSENBLUTH, 1949). More recently, the technology for the direct study of high affinity receptor binding specific to individual neurotransmitters has evolved and with it has grown our knowledge of the complexity of receptor-ligand interactions and subsequent coupling to effector sites in the target cell. It has become clear that cell surface receptors for neurotransmitters can undergo long-lasting changes in sensitivity to ligand that are reciprocal to the frequency of ligand encounter (FRIEDHOFF, 1977). It is further apparent that in some instances the elements coupling cell surface receptors to an effector complex within the cell are capable of independent adaptation. Finally, it is evident that the purposeful manipulation of these receptor systems, by pharmacological strategies, may provide novel means by which to produce long-lasting remediation of some clinical disorders possibly resulting from receptor dysfunction.


Insulin Receptor Dopamine Receptor Adenylate Cyclase Pineal Gland Receptor System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • Kenneth A. Bonnet
    • 1
  1. 1.Millhauser Laboratories Department of PsychiatryNew York University School of MedicineNew YorkUSA

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