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Modulators, Mediators, and Specifiers in Brain Function

Interactions of Neuropeptides, Cyclic Nucleotides, and Phosphoproteins in Mechanisms Underlying Neuronal Activity, Behavior, and Neuropsychiatric Disorders

  • Yigal H. Ehrlich
  • Jan Volavka
  • Leonard G. Davis
  • Eric G. Brunngraber
Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 116)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Mechanisms of Neuronal Communication

  3. Interaction of Neuropeptides, Cyclic Nucleotides and Phosphoproteins in Mechanisms Underlying Receptor Function

    1. Front Matter
      Pages 131-131
    2. David B. Bylund
      Pages 133-162
    3. Arthur J. Blume, Gloria Boone, David Lichtshtein
      Pages 163-174
    4. A. S. Gordon, I. Diamond
      Pages 175-198
    5. Leonard G. Davis, Yigal H. Ehrlich
      Pages 233-244
  4. Clinical Implications

    1. Front Matter
      Pages 245-245
    2. L. Terenius, A. Wahlström
      Pages 261-277
    3. J. Volavka, A. Mallya, J. Bauman, J. Pevnick, D. Cho, D. Reker et al.
      Pages 291-305
    4. H. M. Emrich, V. Höllt, W. Kissling, M. Fischler, H. Heinemann, D. v. Zerssen et al.
      Pages 307-317
  5. Back Matter
    Pages 319-327

About this book

Introduction

While neuroanatomy and neurophysiology were defining the unique features of the synapse as a site for cell to cell signaling in the late fifties, neurochemistry was establishing the identity and studying the biosynthetic pathways of monoamine neurotransmitters. Meanwhile, neuropsychiatry was keeping a vigilant eye on the outcome of this concerted effort with the untold hope that a genetic defect in neurotransmitter metabolism would ac­ count for the pathogenesis of certain psychiatric ill­ nesses. Thus, when neurochemists in the early sixties began to study the feasibility of measuring the metabolism of brain neurotransmitters in vivo, clinical biochemists eagerly adopted these methods to their needs and sought to verify whether inborn errors of transmitter biogenesis were a cause for at least certain forms of depression, mania and schizophrenia. Undoubtedly, it is still too early to evaluate the outcome of these studies. However, current opinion holds that gross inborn errors in transmitter metabolism do not anpear to be operative as a primary cause of psychia­ tric disorders. Though monoamine metabolism appears to be defective in certain groups of psychiatric disorders, the cause of these changes can at best be associated with changes in patterns of neuronal firing. It is generally believed that these persistent changes are determined by a number of unknown factors operative in various psychia­ tric illnesses. In the attempt to identify the molecular nature of these unknown factors, the focus of current research is directed toward transmitter receptors.

Keywords

anatomy brain depression neuroanatomy neurochemistry neurophysiology physiology psychiatry schizophrenia

Editors and affiliations

  • Yigal H. Ehrlich
    • 1
  • Jan Volavka
    • 1
  • Leonard G. Davis
    • 1
  • Eric G. Brunngraber
    • 1
  1. 1.The Missouri Institute of PsychiatryUniversity of Missouri - Columbia School of MedicineSt. LouisUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-3503-0
  • Copyright Information Plenum Press, New York 1979
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-3505-4
  • Online ISBN 978-1-4684-3503-0
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site