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Initiation, Propagation and Arrest of Seizures

  • D. M. Woodbury
  • J. W. Kemp

Abstract

Ideally, the best model to study the mechanisms of seizures is man himself. However, other than EEG recordings, depth electrode studies and occasional biopsies of epileptogenic foci this is difficult to do. This is the case because detailed analysis of the basic neurophysiological and biochemical mechanisms of seizures involves work on the brain itself and sometimes removal of brain samples and this is not possible to do in humans. Consequently, experimental models of epilepsy must be used instead. The relevance of such studies is clearly related to the degree to which the experimental models approximate the disease in humans. The ideal model for studying the basic mechanisms of seizures is one that closely approximates human epilepsy and yet is readily available, inexpensive and easy to work with. No model at present meets all these criteria, but all models are potentially useful for studying at least one aspect of the mechanisms of seizures.

Keywords

Glial Cell Carbonic Anhydrase Spike Activity Carbonic Anhydrase Activity Epileptogenic Focus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • D. M. Woodbury
    • 1
  • J. W. Kemp
    • 1
  1. 1.Department of PharmacologyUniversity of Utah College of MedicineSalt Lake CityUSA

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