Premorbid Adjustment and Response to Nicotinic Acid

  • John R. Wittenborn
Part of the Advances in Behavioral Biology book series (ABBI, volume 14)


Some years ago the Rutgers Interdisciplinary Research Center received what then seemed to be a very large grant to study the hypothesis that nicotinic acid in large doses was effective in the treatment of schizophrenia (Hoffer et al., 1957). The research plan for this comprehensive study provided for a sample of 100 patients on treatment for the course of two years. All of the patients were new admissions at the New Jersey State Hospital at Marlboro. All were males and very few of them could be described as chronic patients. The median duration of prior hospitalization during the preceding five years was 7 1/2 weeks.


Positive Predictor Pretreatment Rating Acanthosis Nigricans Predictor Score Prior Hospitalization 
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  1. Hoffer, A., Osmond, H., Callbeck, M. J., and Kahan, I., 1957, “Treatment of schizophrenia with nicotinic acid and nicotinamide,” J. Clin. Exp. Psychopathol. 18: 131–158.Google Scholar
  2. Brown, J., and Winkelmann, R. K., 1968, “Acanthosis nigricans: A study of 90 cases,” Medicine 47:33–51.CrossRefGoogle Scholar
  3. Wittenborn, J. R., Weber, E. S. P., and Brown, M.,1973, “Niacin in the long-term treatment of schizophrenia,” Arch. Gen. Psychiat. 28:308–315. CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • John R. Wittenborn
    • 1
  1. 1.Interdisciplinary Research CenterRutgers UniversityNew BrunswickUSA

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