The Pathogenic Role of Age-Related Immune Dysfunctions

  • W. Hijmans
  • C. F. Hollander
Part of the Comprehensive Immunology book series (COMIMUN, volume 1)


In this review of the pathogenic role of age-related immune dysfunctions, an outline of the main characteristics of the immune system will be given first because any discussion on aging and immunity should be based on the prevailing immunological theories and models. The age-related immune dysfunctions will then be surveyed and the need for in depth analysis will be emphasized. Finally, an outline of agerelated pathology, which could be a consequence of the age-related dysfunctions, will be discussed. These dysfunctions could themselves be the results of minor defects and, therefore, difficult to detect. Genetic factors may play a major role in their development.


Cellular Immunity Pathogenic Role Immune Dysfunction Autoimmune Thyroiditis Immune Complex Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Allison, A. C., Monga, J. N., and Hammond, V., 1974, Increased susceptibility to virus oncogenesis of congenitally thymus-deprived nude mice, Nature 252:746–747.PubMedCrossRefGoogle Scholar
  2. Anderson, R. E., 1976, Use of germfree animals to study immunity and aging, in this volume.Google Scholar
  3. Benner, R., Meima, F., Meulen, G. van der, and Ewijk, W. van, 1974, Antibody formation in mouse bone marrow. III. Effects of route of priming and antigen dose, Immunology 27:747–760.PubMedGoogle Scholar
  4. Blankwater, M. J., Levert, L. L., and Hijmans, W., 1975, Age-related decline in the antibody response to E. coli lipopolysaccharide in New Zealand Black mice, Immunology 28:847–854.PubMedGoogle Scholar
  5. Boorman, G. A., Lina, P. H. C., Hollander, C. F., and Zurcher, C., 1977, The occurrence of spontaneous tumors following neonatal thymectomy in the WAG/Rij rat, to be published.Google Scholar
  6. Burnet, F. M., 1970, The concept of immunological surveillance, Prog. Exp. Tumor Res. 13:1–27.PubMedGoogle Scholar
  7. Cochrane, C. G., and Koffler, D., 1973, Immune complex disease in experimental animals and man, in: Advances in Immunology, (F. J. Dixon and H. G. Kunkel, eds.), pp. 185–264, Academic Press, New York.Google Scholar
  8. Dunn, T., 1967, Amyloidosis in mice, in: Pathology of Laboratory Rats and Mice (E. Cotchin and F. J. C. Roe, eds.), pp. 181–212, Blackwell Scientific Publ., Oxford.Google Scholar
  9. Ehrlich, P., 1906, Experimentelle Carcinomstudien an Mäusen, Arb. Inst. exp. Ther. Frankfurt 1:15–102. Reprinted in: Paul Ehrlich: Gesammelte Arbeiten, Zweiter Band (F. Himmelweit, ed.), pp. 493–511, 1957, Pergamon Press, London.Google Scholar
  10. Ehrlich, P., 1909, Über den jetzigen Stand der Karzinomforschung. Ned. Tijdschr. Geneesk. 53:273–290. Reprinted in: Paul Ehrlich: Gesammelte Arbeiten, Zweiter Band (F. Himmelweit, ed.), pp. 550–562, 1957, Pergamon Press, London.Google Scholar
  11. Elkerbout, E. A. S., and Hijmans, W., 1974, Relative avidity of antibodies towards sheep red blood cells in New Zealand Black mice, Immunology 26:901–907.PubMedGoogle Scholar
  12. Englisova, M., Englis, M., Kyral, V., Kourilek, K., and Dvorak, D., 1968, Changes of immunoglobulin synthesis in old people, Exp. Gerontol. 3:125–127.PubMedCrossRefGoogle Scholar
  13. Friou, G. J., and Teague, P. O., 1964, Spontaneous autoimmunity in mice: Antibodies to nucleoprotein in strain A/J, Science 143:1333–1334.CrossRefGoogle Scholar
  14. Gerbase-DeLima, M., Wilkinson, J., Smith, G. S., and Walford, R. L., 1974, Age-related decline in thymic-independent immune function in a long-lived mouse strain, J. Geront. 29:261–268.PubMedGoogle Scholar
  15. Good, R. A., 1974, The lymphoid system, immunodeficiency, and malignancy, in: Advances in the Biosciences 12 (G. Raspé and S. Bernard, eds.), pp. 123–159, Pergamon Press, Vieweg.Google Scholar
  16. Goodman, S. A., and Makinodan, T., 1975, Effect of age on cell-mediated immunity in long-lived mice, Clin. exp. Immunol. 19:533–542.PubMedGoogle Scholar
  17. Grossman, J., Baum, J., Gluckman, J., Fusner, J., and Condemi, J. J., 1975, The effect of aging and acute illness on delayed hypersensitivity, J. Allergy Clin. Immunol. 55:268–275.PubMedCrossRefGoogle Scholar
  18. Hori, Y., Perkins, E. H., and Halsall, M. K., 1973, Decline in phytohemagglutinin responsiveness of spleen cells from aging mice, Proc. Soc. Exp. Biol. Med. 144:48–53.PubMedGoogle Scholar
  19. Jaroslow, B. N., Suhrbier, K. M., and Fritz, T. E., 1974, Decline and restoration of antibody forming capacity in aging beagle dogs, J. Immunol. 112:1467–1476.PubMedGoogle Scholar
  20. Jerne, N. K., 1973, The immune system, Sci. Am. 1973:52–60.CrossRefGoogle Scholar
  21. Jerne, N. K., 1976, The immune system: A web of V-domains, in: The Harvey Lectures, 1975–1976, Academic Press, New York, 1976.Google Scholar
  22. Katz, F. E., and Steward, M. W., 1975, The genetic control of antibody affinity in mice, Immunology 29:543–548.PubMedGoogle Scholar
  23. Kim, U., Baumler, A., Carruthers, C., and Bielat, K., 1975, Immunological escape mechanism in spontaneously metastasizing mammary tumors, Proc. Nat. Acad. Sci. U.S. 72:1012–1016.CrossRefGoogle Scholar
  24. Klein, G., 1975, Immunological surveillance against neoplasia, in: The Harvey Lectures, 1973–1974, p. 71, Academic Press, New York.Google Scholar
  25. Konen, T. G., Smith, G. S., and Walford, R. L., 1973, Decline in mixed lymphocyte reactivity of spleen cells from aged mice of a long-lived strain, J. Immunol. 110:1216–1221.PubMedGoogle Scholar
  26. Lawrence, J. S., and Wood, P. H. N., 1966, Criteria for rheumatoid arthritis in population samples, in: Population Studies of the Rheumatic Diseases (P. H. Bennett and P. H. N. Wood, eds.), pp. 164–174, Excerpta Medica Foundation, New York.Google Scholar
  27. Leibowitz, S., and Schwartz, R. S., 1971, Malignancy as a complication of immunosuppressive therapy, Adv. Int. Med. 17:95–123.Google Scholar
  28. Makinodan, T., Perkins, E. H., and Chen, M. G., 1971, Immunologic activity of the aged, in: Advances in Gerontological Research, Vol. 3 (B. L. Strehler, ed.), pp. 171–198, Academic Press, New York.Google Scholar
  29. Makinodan, T., Heidrick, M. L., and Nordin, A. A., 1975, Immunodeficiency and autoimmunity in aging, in: Immunodeficiency in Man and Animals (D. Bergsma, ed.), pp. 193–198, Sinauer Associates Inc., Sunderland, Mass.Google Scholar
  30. Mellors, R. C., and Huang, C. Y., 1966, Immunopathology of NZB/BL mice. V. Viruslike (filtrable) agent separable from lymphoma cells and identifiable by electron microscopy, J. Exp. Med. 124:1031–1038.PubMedCrossRefGoogle Scholar
  31. Myerowitz, R. L., Medeiros, A. A., and O’Brien, T. F., 1971, Recent experience with bacillemia due to Gram-negative organisms, J. Infect. Dis. 124:239–246.PubMedCrossRefGoogle Scholar
  32. Penn, I., 1974, Occurrence of cancer in immune deficiencies, Cancer 34:858–866.PubMedCrossRefGoogle Scholar
  33. Prehn, R. T., 1974, Immunomodulation of tumor growth, Am. J. Pathol. 77:119–122.PubMedGoogle Scholar
  34. Prehn, R. T., 1974, Immunological surveillance: Pro and Con, Clin. Immunol. 2:191–203.Google Scholar
  35. Rádl, J., and Hollander, C. F., 1974, Homogeneous immunoglobulins in sera of mice during aging, J. Immunol. 112:2271–2273.PubMedGoogle Scholar
  36. Rádl, J., Sepers, J. M., Skvaril, F., Morell, A., and Hijmans, W., 1975, Immunoglobulin patterns in humans over 95 years of age, Clin. exp. Immunol. 22:84–90.PubMedGoogle Scholar
  37. Roberts-Thomson, I. C., Wittingham, S., Youngchaiyud, U., and Mackay, I. R., 1974, Ageing, immune response, and mortality, Lancet II, 7877:368–370.CrossRefGoogle Scholar
  38. Rosenthal, C. J., and Franklin, E. C., 1975, Variation with age and disease of an amyloid A protein-related serum component, J. Clin. Invest. 55:746–753.PubMedCrossRefGoogle Scholar
  39. Schreffler, D. C., and Davis, C. S., 1975, The H-2 major histocompatibility complex and the I immune response region: Genetic variation, function and organization, in: Advances in Immunology (F. J. Dixon and H. G. Kunkel, eds.), pp. 125–190, Academic Press, New York.CrossRefGoogle Scholar
  40. Steward, M. W., Katz, F. E., and West, N. J., 1975, The role of low affinity antibody in immune complex disease. The quantity of anti-DNA antibodies in NZB/W F1 hybrid mice, Clin. exp. Immunol. 21:121–130.PubMedGoogle Scholar
  41. Stutman, O., 1974, Cell-mediated immunity and aging, Fed. Proc. 33:2028–2032.PubMedGoogle Scholar
  42. Teague, P. O., 1974, Spontaneous autoimmunity and involution of the lymphoid system, Fed. Proc. 33:2051–2052.PubMedGoogle Scholar
  43. Teilum, G., 1967, Origin of amyloidosis from PAS-positive, reticuloendothelial cells in situ and basic factors in pathogenesis, in: Amyloidosis, (E. Mandema, L. Ruinen, J. H. Scholten, and A. S. Cohen, eds.), pp. 37–44, Excerpta Medica Foundation, Amsterdam.Google Scholar
  44. Thomas, L., 1959, Reactions to homologous tissue antigens in relation to hypersensitivity, in: Cellular and Humoral Aspects of the Hypersensitive States (H. S. Lawrence, ed.), pp. 529–532, Hoeber-Harper, New York.Google Scholar
  45. Walford, R. L., 1969, The immunologic theory of aging, Munksgaard, Copenhagen.Google Scholar
  46. Williams, E. D., and Doniach, I., 1962, The post-mortem incidence of focal thyroiditis, J. Path. Bact. 83:255–264.PubMedCrossRefGoogle Scholar
  47. Yunis, E. J., and Greenberg, L. J., 1974, Immunopathology of aging, Fed. Proc. 33:2017–2019PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • W. Hijmans
    • 1
  • C. F. Hollander
    • 1
  1. 1.Institute for Experimental Gerontology of the Organization for Health Research TNORijswijk (ZH)The Netherlands

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