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The Pathogenic Role of Age-Related Immune Dysfunctions

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Immunology and Aging

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 1))

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Abstract

In this review of the pathogenic role of age-related immune dysfunctions, an outline of the main characteristics of the immune system will be given first because any discussion on aging and immunity should be based on the prevailing immunological theories and models. The age-related immune dysfunctions will then be surveyed and the need for in depth analysis will be emphasized. Finally, an outline of agerelated pathology, which could be a consequence of the age-related dysfunctions, will be discussed. These dysfunctions could themselves be the results of minor defects and, therefore, difficult to detect. Genetic factors may play a major role in their development.

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References

  • Allison, A. C., Monga, J. N., and Hammond, V., 1974, Increased susceptibility to virus oncogenesis of congenitally thymus-deprived nude mice, Nature 252:746–747.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, R. E., 1976, Use of germfree animals to study immunity and aging, in this volume.

    Google Scholar 

  • Benner, R., Meima, F., Meulen, G. van der, and Ewijk, W. van, 1974, Antibody formation in mouse bone marrow. III. Effects of route of priming and antigen dose, Immunology 27:747–760.

    PubMed  CAS  Google Scholar 

  • Blankwater, M. J., Levert, L. L., and Hijmans, W., 1975, Age-related decline in the antibody response to E. coli lipopolysaccharide in New Zealand Black mice, Immunology 28:847–854.

    PubMed  CAS  Google Scholar 

  • Boorman, G. A., Lina, P. H. C., Hollander, C. F., and Zurcher, C., 1977, The occurrence of spontaneous tumors following neonatal thymectomy in the WAG/Rij rat, to be published.

    Google Scholar 

  • Burnet, F. M., 1970, The concept of immunological surveillance, Prog. Exp. Tumor Res. 13:1–27.

    PubMed  CAS  Google Scholar 

  • Cochrane, C. G., and Koffler, D., 1973, Immune complex disease in experimental animals and man, in: Advances in Immunology, (F. J. Dixon and H. G. Kunkel, eds.), pp. 185–264, Academic Press, New York.

    Google Scholar 

  • Dunn, T., 1967, Amyloidosis in mice, in: Pathology of Laboratory Rats and Mice (E. Cotchin and F. J. C. Roe, eds.), pp. 181–212, Blackwell Scientific Publ., Oxford.

    Google Scholar 

  • Ehrlich, P., 1906, Experimentelle Carcinomstudien an Mäusen, Arb. Inst. exp. Ther. Frankfurt 1:15–102. Reprinted in: Paul Ehrlich: Gesammelte Arbeiten, Zweiter Band (F. Himmelweit, ed.), pp. 493–511, 1957, Pergamon Press, London.

    Google Scholar 

  • Ehrlich, P., 1909, Über den jetzigen Stand der Karzinomforschung. Ned. Tijdschr. Geneesk. 53:273–290. Reprinted in: Paul Ehrlich: Gesammelte Arbeiten, Zweiter Band (F. Himmelweit, ed.), pp. 550–562, 1957, Pergamon Press, London.

    Google Scholar 

  • Elkerbout, E. A. S., and Hijmans, W., 1974, Relative avidity of antibodies towards sheep red blood cells in New Zealand Black mice, Immunology 26:901–907.

    PubMed  CAS  Google Scholar 

  • Englisova, M., Englis, M., Kyral, V., Kourilek, K., and Dvorak, D., 1968, Changes of immunoglobulin synthesis in old people, Exp. Gerontol. 3:125–127.

    Article  PubMed  CAS  Google Scholar 

  • Friou, G. J., and Teague, P. O., 1964, Spontaneous autoimmunity in mice: Antibodies to nucleoprotein in strain A/J, Science 143:1333–1334.

    Article  Google Scholar 

  • Gerbase-DeLima, M., Wilkinson, J., Smith, G. S., and Walford, R. L., 1974, Age-related decline in thymic-independent immune function in a long-lived mouse strain, J. Geront. 29:261–268.

    PubMed  CAS  Google Scholar 

  • Good, R. A., 1974, The lymphoid system, immunodeficiency, and malignancy, in: Advances in the Biosciences 12 (G. Raspé and S. Bernard, eds.), pp. 123–159, Pergamon Press, Vieweg.

    Google Scholar 

  • Goodman, S. A., and Makinodan, T., 1975, Effect of age on cell-mediated immunity in long-lived mice, Clin. exp. Immunol. 19:533–542.

    PubMed  CAS  Google Scholar 

  • Grossman, J., Baum, J., Gluckman, J., Fusner, J., and Condemi, J. J., 1975, The effect of aging and acute illness on delayed hypersensitivity, J. Allergy Clin. Immunol. 55:268–275.

    Article  PubMed  CAS  Google Scholar 

  • Hori, Y., Perkins, E. H., and Halsall, M. K., 1973, Decline in phytohemagglutinin responsiveness of spleen cells from aging mice, Proc. Soc. Exp. Biol. Med. 144:48–53.

    PubMed  CAS  Google Scholar 

  • Jaroslow, B. N., Suhrbier, K. M., and Fritz, T. E., 1974, Decline and restoration of antibody forming capacity in aging beagle dogs, J. Immunol. 112:1467–1476.

    PubMed  CAS  Google Scholar 

  • Jerne, N. K., 1973, The immune system, Sci. Am. 1973:52–60.

    Article  Google Scholar 

  • Jerne, N. K., 1976, The immune system: A web of V-domains, in: The Harvey Lectures, 1975–1976, Academic Press, New York, 1976.

    Google Scholar 

  • Katz, F. E., and Steward, M. W., 1975, The genetic control of antibody affinity in mice, Immunology 29:543–548.

    PubMed  CAS  Google Scholar 

  • Kim, U., Baumler, A., Carruthers, C., and Bielat, K., 1975, Immunological escape mechanism in spontaneously metastasizing mammary tumors, Proc. Nat. Acad. Sci. U.S. 72:1012–1016.

    Article  CAS  Google Scholar 

  • Klein, G., 1975, Immunological surveillance against neoplasia, in: The Harvey Lectures, 1973–1974, p. 71, Academic Press, New York.

    Google Scholar 

  • Konen, T. G., Smith, G. S., and Walford, R. L., 1973, Decline in mixed lymphocyte reactivity of spleen cells from aged mice of a long-lived strain, J. Immunol. 110:1216–1221.

    PubMed  CAS  Google Scholar 

  • Lawrence, J. S., and Wood, P. H. N., 1966, Criteria for rheumatoid arthritis in population samples, in: Population Studies of the Rheumatic Diseases (P. H. Bennett and P. H. N. Wood, eds.), pp. 164–174, Excerpta Medica Foundation, New York.

    Google Scholar 

  • Leibowitz, S., and Schwartz, R. S., 1971, Malignancy as a complication of immunosuppressive therapy, Adv. Int. Med. 17:95–123.

    CAS  Google Scholar 

  • Makinodan, T., Perkins, E. H., and Chen, M. G., 1971, Immunologic activity of the aged, in: Advances in Gerontological Research, Vol. 3 (B. L. Strehler, ed.), pp. 171–198, Academic Press, New York.

    Google Scholar 

  • Makinodan, T., Heidrick, M. L., and Nordin, A. A., 1975, Immunodeficiency and autoimmunity in aging, in: Immunodeficiency in Man and Animals (D. Bergsma, ed.), pp. 193–198, Sinauer Associates Inc., Sunderland, Mass.

    Google Scholar 

  • Mellors, R. C., and Huang, C. Y., 1966, Immunopathology of NZB/BL mice. V. Viruslike (filtrable) agent separable from lymphoma cells and identifiable by electron microscopy, J. Exp. Med. 124:1031–1038.

    Article  PubMed  CAS  Google Scholar 

  • Myerowitz, R. L., Medeiros, A. A., and O’Brien, T. F., 1971, Recent experience with bacillemia due to Gram-negative organisms, J. Infect. Dis. 124:239–246.

    Article  PubMed  CAS  Google Scholar 

  • Penn, I., 1974, Occurrence of cancer in immune deficiencies, Cancer 34:858–866.

    Article  PubMed  Google Scholar 

  • Prehn, R. T., 1974, Immunomodulation of tumor growth, Am. J. Pathol. 77:119–122.

    PubMed  CAS  Google Scholar 

  • Prehn, R. T., 1974, Immunological surveillance: Pro and Con, Clin. Immunol. 2:191–203.

    Google Scholar 

  • Rádl, J., and Hollander, C. F., 1974, Homogeneous immunoglobulins in sera of mice during aging, J. Immunol. 112:2271–2273.

    PubMed  Google Scholar 

  • Rádl, J., Sepers, J. M., Skvaril, F., Morell, A., and Hijmans, W., 1975, Immunoglobulin patterns in humans over 95 years of age, Clin. exp. Immunol. 22:84–90.

    PubMed  Google Scholar 

  • Roberts-Thomson, I. C., Wittingham, S., Youngchaiyud, U., and Mackay, I. R., 1974, Ageing, immune response, and mortality, Lancet II, 7877:368–370.

    Article  Google Scholar 

  • Rosenthal, C. J., and Franklin, E. C., 1975, Variation with age and disease of an amyloid A protein-related serum component, J. Clin. Invest. 55:746–753.

    Article  PubMed  CAS  Google Scholar 

  • Schreffler, D. C., and Davis, C. S., 1975, The H-2 major histocompatibility complex and the I immune response region: Genetic variation, function and organization, in: Advances in Immunology (F. J. Dixon and H. G. Kunkel, eds.), pp. 125–190, Academic Press, New York.

    Chapter  Google Scholar 

  • Steward, M. W., Katz, F. E., and West, N. J., 1975, The role of low affinity antibody in immune complex disease. The quantity of anti-DNA antibodies in NZB/W F1 hybrid mice, Clin. exp. Immunol. 21:121–130.

    PubMed  CAS  Google Scholar 

  • Stutman, O., 1974, Cell-mediated immunity and aging, Fed. Proc. 33:2028–2032.

    PubMed  CAS  Google Scholar 

  • Teague, P. O., 1974, Spontaneous autoimmunity and involution of the lymphoid system, Fed. Proc. 33:2051–2052.

    PubMed  CAS  Google Scholar 

  • Teilum, G., 1967, Origin of amyloidosis from PAS-positive, reticuloendothelial cells in situ and basic factors in pathogenesis, in: Amyloidosis, (E. Mandema, L. Ruinen, J. H. Scholten, and A. S. Cohen, eds.), pp. 37–44, Excerpta Medica Foundation, Amsterdam.

    Google Scholar 

  • Thomas, L., 1959, Reactions to homologous tissue antigens in relation to hypersensitivity, in: Cellular and Humoral Aspects of the Hypersensitive States (H. S. Lawrence, ed.), pp. 529–532, Hoeber-Harper, New York.

    Google Scholar 

  • Walford, R. L., 1969, The immunologic theory of aging, Munksgaard, Copenhagen.

    Google Scholar 

  • Williams, E. D., and Doniach, I., 1962, The post-mortem incidence of focal thyroiditis, J. Path. Bact. 83:255–264.

    Article  PubMed  CAS  Google Scholar 

  • Yunis, E. J., and Greenberg, L. J., 1974, Immunopathology of aging, Fed. Proc. 33:2017–2019

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Experimental Gerontology of the Organization for Health Research TNO, 151 Lange Kleiweg, Rijswijk (ZH), The Netherlands

    W. Hijmans & C. F. Hollander

Authors
  1. W. Hijmans
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  2. C. F. Hollander
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Editor information

Editors and Affiliations

  1. Baltimore City Hospitals, Baltimore, Maryland, USA

    Takashi Makinodan

  2. Veterans Administration Wadsworth Hospital Center, USA

    Takashi Makinodan

  3. University of California, Los Angeles, USA

    Takashi Makinodan

  4. Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

    Edmond Yunis

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© 1977 Plenum Publishing Corporation

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Hijmans, W., Hollander, C.F. (1977). The Pathogenic Role of Age-Related Immune Dysfunctions. In: Makinodan, T., Yunis, E. (eds) Immunology and Aging. Comprehensive Immunology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2541-3_3

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  • DOI: https://doi.org/10.1007/978-1-4684-2541-3_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2543-7

  • Online ISBN: 978-1-4684-2541-3

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