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Congenitally Athymic (Nude) Mice and Their Application to the Study of Immunity and Aging

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Immunology and Aging

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 1))

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Abstract

Numerous studies in several mammalian species, including man, mice, rats, and hamsters have established a strong relationship between the aging process and a decline in the functional capacity of the immune system (Walford, 1969). The socalled immunologic theory of aging predicts that genetic and induced defects in the immune apparatus may seriously compromise the general health of man or animals by failing to thwart infections and neoplasia on the one hand, and, on the other, by responding to self-antigens to produce destructive autoimmune disorders.

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Author information

Authors and Affiliations

  1. Department of Microbiology, Montana State University, Bozeman, Montana, USA

    John W. Jutila

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  1. John W. Jutila
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Editor information

Editors and Affiliations

  1. Baltimore City Hospitals, Baltimore, Maryland, USA

    Takashi Makinodan

  2. Veterans Administration Wadsworth Hospital Center, USA

    Takashi Makinodan

  3. University of California, Los Angeles, USA

    Takashi Makinodan

  4. Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

    Edmond Yunis

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© 1977 Plenum Publishing Corporation

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Jutila, J.W. (1977). Congenitally Athymic (Nude) Mice and Their Application to the Study of Immunity and Aging. In: Makinodan, T., Yunis, E. (eds) Immunology and Aging. Comprehensive Immunology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2541-3_12

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  • DOI: https://doi.org/10.1007/978-1-4684-2541-3_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2543-7

  • Online ISBN: 978-1-4684-2541-3

  • eBook Packages: Springer Book Archive

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