Advertisement

Proliferating Cells in Demyelinating States

  • M. I. Reunanen
  • J. Ilonen
  • K. Järvenpää
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 100)

Summary

Proliferation of mononuclear cells was examined with an auto-radiography method in the CSF and peripheral blood of 13 patients with multiple sclerosis (MS), serially during activation of disease in one patient with subacute sclerosis panencephalitis (SSPE), and in some control patients with various neurological conditions. High cerebrospinal fluid (CSF) cell labelling indices, up to 1.7%, which could not be directly related to the clinical activity of the disease, were found in some MS patients. During activation of SSPE there was marked increase in labelled cells of CSF, up to 4.3%. In controls, corresponding CSF indices ranged from < 0.1% to 0.4%. Mononuclear cells in CSF and peripheral blood behaved as clearly different cell populations.

Keywords

Multiple Sclerosis Multiple Sclerosis Patient Labelling Index Demyelinating Disease Labelling Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bøyum, A., Isolation of mononuclear cells and granulocytes from human blood, Scand. J. clin. Lab. Invest. 21, suppl. 97 (1968) 77–89.CrossRefGoogle Scholar
  2. 2.
    Cook, S.D. and Dowling, P.G., Neurologic disorders associated with increased DNA synthesis in peripheral blood, Arch. Neurol. 19 (1968) 583–590.PubMedCrossRefGoogle Scholar
  3. 3.
    Dommasch, D., Grüninger, W. and Schultze, B., Autoradiographic demonstration of proliferating cells in cerebrospinal fluid, J. Neurol. 214 (1977) 97–112.PubMedCrossRefGoogle Scholar
  4. 4.
    Fukui, M., Yamakawa, Y., Yamasaki, T., Kitamura, K., Tabira, T. and Sadoshima, S., 3H-thymidine autoradiography of CSF cells in primary reticulum cell sarcoma of the brain, J. Neurol. 210 (1975) 143–150.PubMedCrossRefGoogle Scholar
  5. 5.
    Haire, M., Significance of virus antibodies in multiple sclerosis, Brit. Med. Bull. 33 (1977) 40–44.PubMedGoogle Scholar
  6. 6.
    Knight, S.C., Cellular immunity in multiple sclerosis, Brit. Med. Bull. 33 (1977) 45–50.PubMedGoogle Scholar
  7. 7.
    Lalla, M., Proliferation of circulating human white cells in health and in non-neoplastic disorders. Academic dissertation, University of Helsinki, Helsinki (1974).Google Scholar
  8. 8.
    Wood, T.A. and Frenkel, E.P., The atypical lymphocyte, Amer. J. Med. 42 (1967) 923–936.PubMedCrossRefGoogle Scholar
  9. 9.
    Yamakawa, Y., Fukui, M., Ohta, H. and Kitamura, K., 3H-thymidine autoradiography of the CSF cells in cases of nonneoplastic disease, J. Neurol. 211 (1976) 195–202.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • M. I. Reunanen
    • 1
    • 2
  • J. Ilonen
    • 1
    • 2
  • K. Järvenpää
    • 1
    • 2
  1. 1.Department of Neurology and Radiotherapy and Public Health LaboratoryUniversity of OuluOuluFinland
  2. 2.Department of Radiotherapy and Public Health LaboratoryUniversity of OuluOuluFinland

Personalised recommendations