Summary
Proliferation of mononuclear cells was examined with an auto-radiography method in the CSF and peripheral blood of 13 patients with multiple sclerosis (MS), serially during activation of disease in one patient with subacute sclerosis panencephalitis (SSPE), and in some control patients with various neurological conditions. High cerebrospinal fluid (CSF) cell labelling indices, up to 1.7%, which could not be directly related to the clinical activity of the disease, were found in some MS patients. During activation of SSPE there was marked increase in labelled cells of CSF, up to 4.3%. In controls, corresponding CSF indices ranged from < 0.1% to 0.4%. Mononuclear cells in CSF and peripheral blood behaved as clearly different cell populations.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bøyum, A., Isolation of mononuclear cells and granulocytes from human blood, Scand. J. clin. Lab. Invest. 21, suppl. 97 (1968) 77–89.
Cook, S.D. and Dowling, P.G., Neurologic disorders associated with increased DNA synthesis in peripheral blood, Arch. Neurol. 19 (1968) 583–590.
Dommasch, D., Grüninger, W. and Schultze, B., Autoradiographic demonstration of proliferating cells in cerebrospinal fluid, J. Neurol. 214 (1977) 97–112.
Fukui, M., Yamakawa, Y., Yamasaki, T., Kitamura, K., Tabira, T. and Sadoshima, S., 3H-thymidine autoradiography of CSF cells in primary reticulum cell sarcoma of the brain, J. Neurol. 210 (1975) 143–150.
Haire, M., Significance of virus antibodies in multiple sclerosis, Brit. Med. Bull. 33 (1977) 40–44.
Knight, S.C., Cellular immunity in multiple sclerosis, Brit. Med. Bull. 33 (1977) 45–50.
Lalla, M., Proliferation of circulating human white cells in health and in non-neoplastic disorders. Academic dissertation, University of Helsinki, Helsinki (1974).
Wood, T.A. and Frenkel, E.P., The atypical lymphocyte, Amer. J. Med. 42 (1967) 923–936.
Yamakawa, Y., Fukui, M., Ohta, H. and Kitamura, K., 3H-thymidine autoradiography of the CSF cells in cases of nonneoplastic disease, J. Neurol. 211 (1976) 195–202.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Plenum Press, New York
About this chapter
Cite this chapter
Reunanen, M.I., Ilonen, J., Järvenpää, K. (1978). Proliferating Cells in Demyelinating States. In: Palo, J. (eds) Myelination and Demyelination. Advances in Experimental Medicine and Biology, vol 100. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2514-7_41
Download citation
DOI: https://doi.org/10.1007/978-1-4684-2514-7_41
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-2516-1
Online ISBN: 978-1-4684-2514-7
eBook Packages: Springer Book Archive