Abstract
The aim of this chapter is to review advances made within the last year in understanding normal and pathological function of the adrenal cortex. The initial sections deal primarily with events that occur at the molecular and cellular levels, while subsequent sections deal with disorders of adrenal function in the intact organism. An appreciation of the former is essential to clear understanding of the latter. In addition, examination of the action of adrenocorticotropin (ACTH) on specific molecular events within adrenal cells may result in better understanding of polypeptide hormone action in general.
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References
Oelofsen, W., 1975, The chemistry of the adrenocorticotropic and the melanotropins, Pharmacol. Ther. B 1:459–500.
Felber, J. P., 1975, Immunochemistry of adrenocorticotropin, melanotropins and lipotropins, Pharmacol Ther. B 1:571–586.
Yalow, R. S., and Berson, S. A., 1971, Size heterogeneity of innumoreactive human ACTH in plasma and in extracts of pituitary glands and ACTH-producing thymoma, Biochem. Biophys. Res. Commun. 44:439–445.
Gewirtz, G., Schneider, B., Krieger, D. T., and Yalow, R. S., 1974, Big ACTH: Conversion to biologically active ACTH by trypsin,J. Clin. Endocrinol. Metab. 38:227–230.
Eipper, B. A., and Mains, R. E., 1975, High molecular weight forms of adrenocorticotropic hormone in the mouse pituitary and in a mouse pituitary tumor cell line, Biochemistry 14:3836–3844.
Mains, R. E., and Eipper, B. A., 1976, Biosynthesis of adrenocorticotropic hormone in mouse pituitary tumor cells,J. Biol. Chem. 251:4115–4120.
Eipper, B. A., Mains, R. E., and Guenzi, D., 1976, High molecular weight forms of adrenocorticotropic hormone are glycoproteins, J. Biol. Chem. 251:4121–4126.
Nakanishi, S., Taii, S., Hirata, Y., Matsukura, S., Imura, H., and Numa, S., 1976, A large product of cell-free translation of messenger RNA coding for corticotropin, Proc. Natl. Acad. Sci. U.S.A. 73:4319–4323.
Krieger, D. T., Choi, H.-S. H., and Anderson, P. J., 1976, The characterization of the ACTH produced by a primary pituitary tumour in a patient with Cushing’s disease, Clin. Endocrinol. (Oxford) 5:455–472.
Orth, D. N., and Nicholson, W., 1977, High molecular weight forms of human ACTH are glycoproteins,J. Clin. Endocrinol. Metab. 44:214–217.
Pelletier, G, Leclerc, R., Labrie, F., Cote, J., Chretien, M., and Lis, M., 1977, Immunohistochemical localization of β-lipotropic hormone in the pituitary gland, Endocrinology 100:770–776.
Guillemin, R., 1977, Endorphins, brain peptides that act like opiates, N. Engl. J. Med. 296:226–228.
Baumann, G., and Felber, J.-P., 1976, Prolonged corticotropic action of synthetic human ACTH in man,J. Clin. Endocrinol. Metab. 42:160–163.
Otsuka, H., and Inouye, L. K., 1975, Structure-activity relationships of adrenocorticotropin, Pharmacol. Ther. B 1:501–527.
Moyle, W. R., Kong, Y. C., and Ramachandran, J., 1973, Steroidogenesis and cyclic adenosine 3′,5′-monosphosphate accumulation in rat adrenal cells,J. Biol. Chem. 248:2409–2417.
Ramachandran, J., Kong, Y. C., and Liles, S., 1976, Effects of ACTH and its O-nitrophenyl sulphenyl derivative on adrenocortical function in vivo, Acta Endocrinol. (Copenhagen) 82:587–599.
Finn, F. M., Johns, P. A., Nishi, N., and Hofmann, K., 1976, Differential response to adrenocorticotropic hormone analogs of bovine adrenal plasma membranes and cells,J. Biol. Chem. 251:3576–3585.
Ways, D. K., Zimmerman, C. F., and Ontjes, D. A., 1976, Inhibition of adrenocorticotropic effects on adrenal cell membranes by synthetic adrenocorticotropin analogues: Correlation of binding and adenylate cyclase activation, Mol. Pharmacol. 12:789–799.
Lowry, P. J., Rees, L. H., Tomlin, S., Gillies, G., and Landon, J., 1976, Chemical characterization of ectopic ACTH purified from a malignant thymic carcinoid tumor,J. Clin. Endocrinol. Metab. 43:831–835.
Wolff, J., and Cook, G. H., 1977, Activation of steroidogenesis and adenylate cyclase by adenosine in adrenal and Ley dig tumor cells, J. Biol. Chem. 252:687–693.
Glossmann, H., and Gips, H., 1976, Adrenal cortex adenylate cyclase. Is Ca2+ involved in ACTH stimulation?, Naunyn-Schmiedebergs Arch. Pharmakol. 292:199–203.
Haksar, A., Maudsley, D. V., Peron, F. G., and Bedigian, E., 1976, Lanthanum: Inhibition of ACTH-stimula ted cyclic AMP and corticosterone synthesis in isolated rat adrenocortical cells,J. Cell Biol. 68:142–153.
Moyle, W. R., MacDonald, G. J., and Garfink, J. E., 1976, Role of histone kinases as mediators of corticotropin-induced steroidogenesis, Biochem. J. 160:1–9.
Riou, J., Evain, D., Perrin, F., and Saez, J. M., 1977, Adenosine 3′5′-cyclic monophosphate dependent protein kinase in human adrenocortical tumors, J. Clin. Endocrinol. Metab. 44:413–419.
Wang, H., and Kimura, T., 1976, Purification and characterization of adrenal cortex mitochondrial cytochrome P-450 specific for cholesterol side chain cleavage activity,J. Biol. Chem. 251:6068–6074.
Paul, D. P., Gallant, S., Orme-Johnson, N. R., Orme-Johnson, W. H., and Brownie, A. C., 1976, Temperature dependence of cholesterol binding to cytochrome P-450scc of the rat adrenal. Effect of adrenocorticotropic hormone and cycloheximide,J. Biol. Chem. 251:7120–7126.
Williams-Smith, D. L., Simpson, E. R., Barlow, S. M., and Morrison, P. J., 1976, Electron paramagnetic resonance studies of cytochrome P-450 and adrenal ferredoxin in single whole rat adrenal glands, Biochim. Biophys. Acta 449:72–83.
Mahaffee, D., Reitz, R. C., and Ney, R. L., 1974, The mechanism of action of adrenocorticotropic hormone: The role of mitochondrial cholesterol accumulation in the regulation of steroidogenesis,J. Biol. Chem. 249:227–233.
Gill, G. N., 1976, ACTH regulation of the adrenal cortex, Pharmacol. Ther. B 2:313–338.
Asano, K., and Harding, B. W., 1976, Biosynthesis of adrenodoxin in mouse adrenal tumor cells, Endocrinology 99:977–987.
Dazord, A., Gallet, D., and Saez, J. M., 1977, ACTH-dëpendent stimulation of a specific peptide in adrenocortical cells in culture, Bioćhem. Biophys. Res. Commun. 76:1238–1246.
Andersen, J. M., and Dietschy, J. M., 1976, Regulation of sterol synthesis in adrenal gland of the rat by both high and low density human plasma lipoproteins, Biochem. Biophys. Res. Commun. 72:880–885.
Andersen, J. M., and Dietschy, J. M., 1977, Regulation of sterol synthesis in 16 tissues of rat. I. Effect of diurnal light cycling, fasting, stress, manipulation of enterohepatic circulation, and administration of chylomicrons and triton,J. Biol. Chem. 252:3646–3651.
Andersen, J. M., and Dietschy, J. M., 1977, Regulation of sterol synthesis in 15 tissues of rat. II. Role of rat and human high and low density plasma lipoproteins and of rat chylomicron remnants,J. Biol. Chem. 252:3652–3659.
Balasubramaniam, S., Goldstein, J. L., Faust, J. R., Brunschede, G. Y., and Brown, M. S., 1977, Iipoprotein-mediated regulation of 3-hydroxy-3-meth-ylglutaryl coenzyme A reductase activity and cholesterol ester metabolism in the adrenal gland of the rat,J. Biol. Chem. 252:1771–1779.
Balasubramaniam, S., Goldstein, J., and Brown, M., 1977, Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities, Proc. Natl. Acad. Sci. U.S.A. 74:1421–1425.
Gwynne, J. T., Mahaffee, D., Brewer, H. B., Jr., and Ney, R. L., 1976, Adrenal cholesterol uptake from plasma lipoproteins: Regulation by corticotropin, Proc. Natl. Acad. Sci. U.S.A. 73:4329–4333.
Gwynne, J., and Hess, B., 1977, Binding and degradation of human 125I-HDL by rat adrenocortical cells, Metabolism (in press).
Beckett, G. J., and Boyd, G. S., 1975, Evidence for the activation of bovine adrenal cholesterol ester hydrolase by a phosphorylation involving an adenosine 3′:5′-monophosphate-dependent protein kinase, Biochem. Soc. Trans. 3:892–894.
Pittman, R. C., and Steinberg, D., 1977, Activatable cholesterol esterase and triacylglycerol lipase activities of rat adrenal and their relationship, Biochim. Biophys. Acta 487:431–444.
Stylianopoulou, F., and Clayton, R. B., 1976, Strain-dependent gonadal effects upon the response of adrenal cholesterol esters to ACTH in C57BIV10J and DBA/2J mice, Endocrinology 99:1638–1644.
Beckett, G. J., and Boyd, G. S., 1975, The effect of dietary rape-seed oil on cholesterol-ester metabolism and cholesterol-ester-hydrolase activity in rat adrenal, Eur. J. Biochem. 53:335–342.
Naghshineh, S., Treadwell, C. R., Gallo, L., and Vahouny, G. V., 1974, Activation of adrenal sterol ester hydrolase by dibutyryl cAMP and protein kinase, Biochem. Biophys. Res. Commun. 61:1076–1082.
Falke, H. E., Degenhart, H. J., Abeln, G. J., and Visser, H., 1975, Studies on isolated rat adrenal cell metabolism of hydroxylated sterols, Mol. Cell. Endocrinol. 3:375–383.
Falke, H. E., Degenhart, H. J., Abeln, G. J., and Visser, H., 1976, Effects of 25-hydroxycholesterol and aminoglutethimide in isolated rat adrenal cells: A model for congenital lipoid adrenal hyperplasia?, Mol Cell. Endocrinol. 4:107–114.
Saruta, T., and Kaplan, N. M., 1972, Adrenocortical steroidogenesis: The effects of prostaglandins, J. Clin. Invest. 51:2246–2251.
Honn, K. V., and Chavin, W., 1976, Prostaglandin modulation of the mechanism of ACT H action in the human adrenal, Biochem. Biophys. Res. Commun. 73:164–170.
Laychock, S. G., and Rubin, R. P., 1976, Indomethacin-induced alterations in corticosteroid and prostaglandin release by isolated adrenocortical cells of the cat, Br. J. Pharmacol. 57:273–278.
Laychock, S. G., and Rubin, R. P., 1976, Radioimmunoassay measurement of ACTH-facilitated PGE2 and PGE2a release from isolated cat adrenocortical cells, Prostaglandins 11:753–767.
Laychock, S. G., Warner, W., and Rubin, R. P., 1977, Further studies on the mechanisms controlling prostaglandin biosynthesis in the cat adrenal cortex: The role of calcium and cyclic AMP, Endocrinology 100:74–81.
Inrie, R. C., Ramiah, T. R., Antoni, F., and Hutchinson, W. C., 1965, The effect of adrenocorticotrophin on the nucleic acid metabolism of the rat adrenal gland,J. Endocrinol. 32:303–313.
Fuhrman, S. A., and Gill, G. N., 1974, Hormonal control of adrenal RNA polymerase activities, Endocrinology 94:691–700.
Fuhrman, S. A., and Gill, G. N., 1975, Adrenocorticotropic hormone stimulation of adrenal RNA polymerase I and III activities. Nucleotide incorporation into internal positions and 3′ chain termini, Biochemistry 14:2925–2933.
Fuhrman, S. A., and Gill, G. N., 1976, Adrenocorticotropic hormone regulation of adrenal RNA polymerases. Stimulation of nuclear RNA polymerase III, Biochemistry 15:5520–5527.
Saez, J. M., Morera, A. M., and Gallet, D., 1977, Opposite effects of ACTH and glucocorticoids on adrenal DNA synthesis in vivo, Endocrinology 100:1268–1275.
Ramachandran, J., and Suyama, A. T., 1975, Inhibition of replication of normal adrenocortical cells in culture by adrenocorticotropin, Proc. Natl. Acad. Sci. U.S.A. 72:113–117.
O’Hare, J. M., and Neville, A. M., 1973, Effects of adrenocorticotrophin on steroidogenesis and proliferation by adult adrenal cells in monolayer culture, Biochem. Soc. Trans. 1:1088–1091.
Weidman, E. R., and Gill, G. N., 1977, Differential effects of ACTH or 8-Br-cAMP on growth and replication in a functional adrenal tumor cell line, J. Cell. Physiol. 90:91–103.
Gill, G. N., and Weidman, E. R., 1977, Hormonal regulation of initiation of DNA synthesis and of differentiated function in Y-l adrenal cartical cells, J. Cell Physiol. 92:65–76.
Gospodarowicz, D., III, C. R. Hornsby, P. J., and Gill, G. N., 1977, Control of bovine adrenal cortical cell proliferation by fibroblast growth factor: Lack of effect of epidermal growth factor, Endocrinology 100:1080–1089.
Engeland, W. C., Shinsako, J., and Dallman, M. F., 1975, Corticosteroids and ACTH are not required for compensatory adrenal growth, Am. J. Physiol. 229:1461–1464.
Engeland, W. C., and Dallman, M. F., 1975, Compensatory adrenal growth is neurally mediated, Neoroendocrinology 19:352–362.
Dallman, M. F., Engeland, W. C., and Shinsako, J., 1976, Compensatory adrenal growth: A neurally mediated reflex, Am. J. Physiol. 231:408–414.
Engeland, W. C., and Dallman, M. F., 1976, Neural mediation of compensatory adrenal growth, Endocrinology 99:1659–1662.
Lagerquist, L., and Tyler, F., 1976, Diagnosis and treatment of disorders of the adrenal cortex, Pharmacol. Ther. C 1:259–277.
Gwinup, G., and Johnson, B., 1975, Clinical testing of the hypothalamic-pituitary-adrenocortical system in states of hypo- and hypercortisolism, Metabolism 24:777–791.
Liddle, G. W., 1960, Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing’s syndrome,J. Clin. Endocrinol. Metab. 20:1539–1560.
Eddy, R. L., Jones, A. L., Gilliland, P. F., Ibarra, J. D., Jr., Thompson, J. Q., and Mc Murray, J. F., Jr., 1973, Cushing’s syndrome: A prospective study of diagnostic methods, Am. J. Med. 55:621–630.
Mattingly, D., and Tyler, C., 1976, Overnight urinary 11-hydroxycorticosteroid estimations in diagnosis of Cushing’s syndrome, Br. Med. J. 2:668–669.
Liddle, G. W., Estep, H. L., Kendall, J., Williams, W. C., Jr., and Townes, A. W., 1959, Clinical application of a new test of pituitary reserve, J. Clin. Endocrinol. Metab. 19:875–894.
Cheng, S. C., Harding, B. W., and Carballeira, A., 1974, Effects of metyra-pone on pregnenolone biosynthesis and on cholesterol-cytochrome P-450 interaction in the adrenal, Endocrinology 94:1451–1458.
Carballeira, A., Fishman, L. M., and Jacobi, J. D., 1976, Dual sites of inhibition by metyrapone of human adrenal steroidogenesis: Correlation of in vivo and in vitro studies,J. Clin. Endocrinol. Metab. 42:687–695.
Redman, J. F., and Faas, F. H., 1976, Acute unilateral adrenal hemorrhage following ACTH administration in a patient with Cushing’s syndrome, Am. J. Med. 61:533–536.
McKenna, T. J., Miller, R. B., and Liddle, G. W., 1977, Plasma pregnenolone and 17-OH-pregnenolone in patients with adrenal tumors, ACTH excess, or idiopathic hirsutism, J. Clin. Endocrinol. Metab. 44:231–236.
McKenna, T. J., Jennings, A. S., Liddle, G. W., and Burr, I. M., 1977, Pregnenolone, 17-OH-pregnenolone, and testosterone in plasma of patients with congenital adrenal hyperplasia,J. Clin. Endocrinol. Metab. 42:918–925.
Kohlet, H., Blichert-Toft, M., Hancke, S., Pedersen, J. F., Kristensen, J. K., Efsen, F., Dige-Petersen, H., Fogh, J., Lockwood, K., and Hasner, E., 1976, Comparative study of ultrasound, 131I-19-iodocholesterol scintigraphy, and aortography in localising adrenal lesions, Br. Med. J. 2:665–667.
Corrigan, D. F., Schaaf, M., Whaley, R. A., Czerwiński, C. L., and Earll, J. M., 1977, Selective venous sampling to differentiate ectopic ACTH secretion from pituitary Cushing’s syndrome, N. Engl. J. Med. 296:861–862.
Krieger, D. T., and Luria, M., 1977, Plasma ACTH and Cortisol responses to TRF, vasopressin or hypoglycemia in Cushing’s disease and Nelson’s syndrome,J. Clin. Endocrinol. Metab. 44:361–368.
Lagerquist, L. G., Meikle, A. W., West, C. D., and Tyler, F. H., 1974, Cushing’s disease with cure by resection of a pituitary adenoma, Am. J. Med. 57:826–830.
Tyrrell, J. B., Wiener-Kronish, J., Lorenzi, M., Brooks, R. M., and Forsham, P. H., 1977, Cushing’s disease: Growth hormone response to hypoglycemia after correction of hypercortisolism,J. Clin. Endocrinol. Metab. 44:218–221.
James, V. H. T., Landon, J., Wynn, V., and Greenwood, F. C., 1968, A fundamental defect in adrenocortical control in Cushing’s disease,J. Endocrinol. 40:15–28.
Hsu, T.-H., Hsu, C. K., and Gann, D. S., 1976, Potentiation of the ACTH response to metyrapone by L-Dopa in the monkey, Endocrinology 99:1115–1118.
Benker, G., Hackenberg, K., Hamburger, B., and Reinwein, D., 1976, Effects of growth hormone release-inhibiting hormone and bromocryptine (CB 154) in states of abnormal pituitary-adrenal function, Clin. Endocrinol. 5:187–190.
Decker, R. E., Epstein, J. A., Carras, R., and Rosenthal, A. D., 1976, Transsphenoidal microsurgery for pituitary tumors: Experience with 45 cases, Mt. Sinai J. Med. N.Y. 43:565–577.
Ganguly, A., Stanchfield, J., Roberts, R., West, C., and Tyler, F., 1976, Cushing’s syndrome in a patient with an empty sella turcica and a microadenoma of the adenohypophysis, Am. J. Med. 60:306–309.
Lawrence, J. H., Tobias, C. A., Linfoot, J. A., Born, J. L., and Chong, C. Y., 1976, Heavy-particle therapy in acromegaly and Cushing’s disease, J. Am. Med. Assoc. 235:2307–2310.
Cook, D. M., Jordan, R. M., Kendall, J. W., and Linfoot, J. A., 1976, Rapid appearance of transient secondary adrenocortical insufficiency after alpha-particle radiation therapy for Cushing’s disease, J. Clin. Endocrinol. Metab. 43:295–300.
Moore, T. J., Dluhy, R. G., Williams, G. H., and Cain, J. P., 1976, Nelson’s syndrome: Frequency, prognosis, and effect of prior pituitary irradiation, Ann. Intern. Med. 85:731–734.
Krieger, D. T., and Luria, M., 1976, Effectiveness of cyproheptadine in decreasing plasma ACTH concentrations in Nelson’s syndrome, J. Clin. Endocrinol. Metab. 43:1179–1182.
Cassar, J., Doyle, F. H., Lewis, P. D., Mashiter, K., Van Noorden, S., and Joplin, G. F., 1976, Treatment of Nelson’s syndrome by pituitary implantation of yttrium-90 or gold-198, Br. Med. J. 2:269–272.
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Gwynne, J.T., Ney, R.L. (1978). The Adrenal Cortex. In: Ingbar, S.H. (eds) The Year in Endocrinology 1977. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2502-4_5
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