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The Adrenal Cortex

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The Year in Endocrinology 1977
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Abstract

The aim of this chapter is to review advances made within the last year in understanding normal and pathological function of the adrenal cortex. The initial sections deal primarily with events that occur at the molecular and cellular levels, while subsequent sections deal with disorders of adrenal function in the intact organism. An appreciation of the former is essential to clear understanding of the latter. In addition, examination of the action of adrenocorticotropin (ACTH) on specific molecular events within adrenal cells may result in better understanding of polypeptide hormone action in general.

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References

  1. Oelofsen, W., 1975, The chemistry of the adrenocorticotropic and the melanotropins, Pharmacol. Ther. B 1:459–500.

    PubMed  CAS  Google Scholar 

  2. Felber, J. P., 1975, Immunochemistry of adrenocorticotropin, melanotropins and lipotropins, Pharmacol Ther. B 1:571–586.

    PubMed  CAS  Google Scholar 

  3. Yalow, R. S., and Berson, S. A., 1971, Size heterogeneity of innumoreactive human ACTH in plasma and in extracts of pituitary glands and ACTH-producing thymoma, Biochem. Biophys. Res. Commun. 44:439–445.

    Article  PubMed  CAS  Google Scholar 

  4. Gewirtz, G., Schneider, B., Krieger, D. T., and Yalow, R. S., 1974, Big ACTH: Conversion to biologically active ACTH by trypsin,J. Clin. Endocrinol. Metab. 38:227–230.

    Article  PubMed  CAS  Google Scholar 

  5. Eipper, B. A., and Mains, R. E., 1975, High molecular weight forms of adrenocorticotropic hormone in the mouse pituitary and in a mouse pituitary tumor cell line, Biochemistry 14:3836–3844.

    Article  PubMed  CAS  Google Scholar 

  6. Mains, R. E., and Eipper, B. A., 1976, Biosynthesis of adrenocorticotropic hormone in mouse pituitary tumor cells,J. Biol. Chem. 251:4115–4120.

    PubMed  CAS  Google Scholar 

  7. Eipper, B. A., Mains, R. E., and Guenzi, D., 1976, High molecular weight forms of adrenocorticotropic hormone are glycoproteins, J. Biol. Chem. 251:4121–4126.

    PubMed  CAS  Google Scholar 

  8. Nakanishi, S., Taii, S., Hirata, Y., Matsukura, S., Imura, H., and Numa, S., 1976, A large product of cell-free translation of messenger RNA coding for corticotropin, Proc. Natl. Acad. Sci. U.S.A. 73:4319–4323.

    Article  PubMed  CAS  Google Scholar 

  9. Krieger, D. T., Choi, H.-S. H., and Anderson, P. J., 1976, The characterization of the ACTH produced by a primary pituitary tumour in a patient with Cushing’s disease, Clin. Endocrinol. (Oxford) 5:455–472.

    Article  CAS  Google Scholar 

  10. Orth, D. N., and Nicholson, W., 1977, High molecular weight forms of human ACTH are glycoproteins,J. Clin. Endocrinol. Metab. 44:214–217.

    Article  PubMed  CAS  Google Scholar 

  11. Pelletier, G, Leclerc, R., Labrie, F., Cote, J., Chretien, M., and Lis, M., 1977, Immunohistochemical localization of β-lipotropic hormone in the pituitary gland, Endocrinology 100:770–776.

    Article  PubMed  CAS  Google Scholar 

  12. Guillemin, R., 1977, Endorphins, brain peptides that act like opiates, N. Engl. J. Med. 296:226–228.

    Article  PubMed  CAS  Google Scholar 

  13. Baumann, G., and Felber, J.-P., 1976, Prolonged corticotropic action of synthetic human ACTH in man,J. Clin. Endocrinol. Metab. 42:160–163.

    Article  PubMed  CAS  Google Scholar 

  14. Otsuka, H., and Inouye, L. K., 1975, Structure-activity relationships of adrenocorticotropin, Pharmacol. Ther. B 1:501–527.

    PubMed  CAS  Google Scholar 

  15. Moyle, W. R., Kong, Y. C., and Ramachandran, J., 1973, Steroidogenesis and cyclic adenosine 3′,5′-monosphosphate accumulation in rat adrenal cells,J. Biol. Chem. 248:2409–2417.

    PubMed  CAS  Google Scholar 

  16. Ramachandran, J., Kong, Y. C., and Liles, S., 1976, Effects of ACTH and its O-nitrophenyl sulphenyl derivative on adrenocortical function in vivo, Acta Endocrinol. (Copenhagen) 82:587–599.

    PubMed  CAS  Google Scholar 

  17. Finn, F. M., Johns, P. A., Nishi, N., and Hofmann, K., 1976, Differential response to adrenocorticotropic hormone analogs of bovine adrenal plasma membranes and cells,J. Biol. Chem. 251:3576–3585.

    PubMed  CAS  Google Scholar 

  18. Ways, D. K., Zimmerman, C. F., and Ontjes, D. A., 1976, Inhibition of adrenocorticotropic effects on adrenal cell membranes by synthetic adrenocorticotropin analogues: Correlation of binding and adenylate cyclase activation, Mol. Pharmacol. 12:789–799.

    PubMed  CAS  Google Scholar 

  19. Lowry, P. J., Rees, L. H., Tomlin, S., Gillies, G., and Landon, J., 1976, Chemical characterization of ectopic ACTH purified from a malignant thymic carcinoid tumor,J. Clin. Endocrinol. Metab. 43:831–835.

    Article  PubMed  CAS  Google Scholar 

  20. Wolff, J., and Cook, G. H., 1977, Activation of steroidogenesis and adenylate cyclase by adenosine in adrenal and Ley dig tumor cells, J. Biol. Chem. 252:687–693.

    PubMed  CAS  Google Scholar 

  21. Glossmann, H., and Gips, H., 1976, Adrenal cortex adenylate cyclase. Is Ca2+ involved in ACTH stimulation?, Naunyn-Schmiedebergs Arch. Pharmakol. 292:199–203.

    Article  CAS  Google Scholar 

  22. Haksar, A., Maudsley, D. V., Peron, F. G., and Bedigian, E., 1976, Lanthanum: Inhibition of ACTH-stimula ted cyclic AMP and corticosterone synthesis in isolated rat adrenocortical cells,J. Cell Biol. 68:142–153.

    Article  PubMed  CAS  Google Scholar 

  23. Moyle, W. R., MacDonald, G. J., and Garfink, J. E., 1976, Role of histone kinases as mediators of corticotropin-induced steroidogenesis, Biochem. J. 160:1–9.

    PubMed  CAS  Google Scholar 

  24. Riou, J., Evain, D., Perrin, F., and Saez, J. M., 1977, Adenosine 3′5′-cyclic monophosphate dependent protein kinase in human adrenocortical tumors, J. Clin. Endocrinol. Metab. 44:413–419.

    Article  PubMed  CAS  Google Scholar 

  25. Wang, H., and Kimura, T., 1976, Purification and characterization of adrenal cortex mitochondrial cytochrome P-450 specific for cholesterol side chain cleavage activity,J. Biol. Chem. 251:6068–6074.

    PubMed  CAS  Google Scholar 

  26. Paul, D. P., Gallant, S., Orme-Johnson, N. R., Orme-Johnson, W. H., and Brownie, A. C., 1976, Temperature dependence of cholesterol binding to cytochrome P-450scc of the rat adrenal. Effect of adrenocorticotropic hormone and cycloheximide,J. Biol. Chem. 251:7120–7126.

    PubMed  CAS  Google Scholar 

  27. Williams-Smith, D. L., Simpson, E. R., Barlow, S. M., and Morrison, P. J., 1976, Electron paramagnetic resonance studies of cytochrome P-450 and adrenal ferredoxin in single whole rat adrenal glands, Biochim. Biophys. Acta 449:72–83.

    Article  PubMed  CAS  Google Scholar 

  28. Mahaffee, D., Reitz, R. C., and Ney, R. L., 1974, The mechanism of action of adrenocorticotropic hormone: The role of mitochondrial cholesterol accumulation in the regulation of steroidogenesis,J. Biol. Chem. 249:227–233.

    PubMed  CAS  Google Scholar 

  29. Gill, G. N., 1976, ACTH regulation of the adrenal cortex, Pharmacol. Ther. B 2:313–338.

    PubMed  CAS  Google Scholar 

  30. Asano, K., and Harding, B. W., 1976, Biosynthesis of adrenodoxin in mouse adrenal tumor cells, Endocrinology 99:977–987.

    Article  PubMed  CAS  Google Scholar 

  31. Dazord, A., Gallet, D., and Saez, J. M., 1977, ACTH-dëpendent stimulation of a specific peptide in adrenocortical cells in culture, Bioćhem. Biophys. Res. Commun. 76:1238–1246.

    Article  PubMed  CAS  Google Scholar 

  32. Andersen, J. M., and Dietschy, J. M., 1976, Regulation of sterol synthesis in adrenal gland of the rat by both high and low density human plasma lipoproteins, Biochem. Biophys. Res. Commun. 72:880–885.

    Article  PubMed  CAS  Google Scholar 

  33. Andersen, J. M., and Dietschy, J. M., 1977, Regulation of sterol synthesis in 16 tissues of rat. I. Effect of diurnal light cycling, fasting, stress, manipulation of enterohepatic circulation, and administration of chylomicrons and triton,J. Biol. Chem. 252:3646–3651.

    PubMed  CAS  Google Scholar 

  34. Andersen, J. M., and Dietschy, J. M., 1977, Regulation of sterol synthesis in 15 tissues of rat. II. Role of rat and human high and low density plasma lipoproteins and of rat chylomicron remnants,J. Biol. Chem. 252:3652–3659.

    PubMed  CAS  Google Scholar 

  35. Balasubramaniam, S., Goldstein, J. L., Faust, J. R., Brunschede, G. Y., and Brown, M. S., 1977, Iipoprotein-mediated regulation of 3-hydroxy-3-meth-ylglutaryl coenzyme A reductase activity and cholesterol ester metabolism in the adrenal gland of the rat,J. Biol. Chem. 252:1771–1779.

    PubMed  CAS  Google Scholar 

  36. Balasubramaniam, S., Goldstein, J., and Brown, M., 1977, Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities, Proc. Natl. Acad. Sci. U.S.A. 74:1421–1425.

    Article  PubMed  CAS  Google Scholar 

  37. Gwynne, J. T., Mahaffee, D., Brewer, H. B., Jr., and Ney, R. L., 1976, Adrenal cholesterol uptake from plasma lipoproteins: Regulation by corticotropin, Proc. Natl. Acad. Sci. U.S.A. 73:4329–4333.

    Article  PubMed  CAS  Google Scholar 

  38. Gwynne, J., and Hess, B., 1977, Binding and degradation of human 125I-HDL by rat adrenocortical cells, Metabolism (in press).

    Google Scholar 

  39. Beckett, G. J., and Boyd, G. S., 1975, Evidence for the activation of bovine adrenal cholesterol ester hydrolase by a phosphorylation involving an adenosine 3′:5′-monophosphate-dependent protein kinase, Biochem. Soc. Trans. 3:892–894.

    CAS  Google Scholar 

  40. Pittman, R. C., and Steinberg, D., 1977, Activatable cholesterol esterase and triacylglycerol lipase activities of rat adrenal and their relationship, Biochim. Biophys. Acta 487:431–444.

    PubMed  CAS  Google Scholar 

  41. Stylianopoulou, F., and Clayton, R. B., 1976, Strain-dependent gonadal effects upon the response of adrenal cholesterol esters to ACTH in C57BIV10J and DBA/2J mice, Endocrinology 99:1638–1644.

    Article  PubMed  CAS  Google Scholar 

  42. Beckett, G. J., and Boyd, G. S., 1975, The effect of dietary rape-seed oil on cholesterol-ester metabolism and cholesterol-ester-hydrolase activity in rat adrenal, Eur. J. Biochem. 53:335–342.

    Article  PubMed  CAS  Google Scholar 

  43. Naghshineh, S., Treadwell, C. R., Gallo, L., and Vahouny, G. V., 1974, Activation of adrenal sterol ester hydrolase by dibutyryl cAMP and protein kinase, Biochem. Biophys. Res. Commun. 61:1076–1082.

    Article  PubMed  CAS  Google Scholar 

  44. Falke, H. E., Degenhart, H. J., Abeln, G. J., and Visser, H., 1975, Studies on isolated rat adrenal cell metabolism of hydroxylated sterols, Mol. Cell. Endocrinol. 3:375–383.

    Article  PubMed  CAS  Google Scholar 

  45. Falke, H. E., Degenhart, H. J., Abeln, G. J., and Visser, H., 1976, Effects of 25-hydroxycholesterol and aminoglutethimide in isolated rat adrenal cells: A model for congenital lipoid adrenal hyperplasia?, Mol Cell. Endocrinol. 4:107–114.

    Article  PubMed  CAS  Google Scholar 

  46. Saruta, T., and Kaplan, N. M., 1972, Adrenocortical steroidogenesis: The effects of prostaglandins, J. Clin. Invest. 51:2246–2251.

    Article  PubMed  CAS  Google Scholar 

  47. Honn, K. V., and Chavin, W., 1976, Prostaglandin modulation of the mechanism of ACT H action in the human adrenal, Biochem. Biophys. Res. Commun. 73:164–170.

    Article  PubMed  CAS  Google Scholar 

  48. Laychock, S. G., and Rubin, R. P., 1976, Indomethacin-induced alterations in corticosteroid and prostaglandin release by isolated adrenocortical cells of the cat, Br. J. Pharmacol. 57:273–278.

    PubMed  CAS  Google Scholar 

  49. Laychock, S. G., and Rubin, R. P., 1976, Radioimmunoassay measurement of ACTH-facilitated PGE2 and PGE2a release from isolated cat adrenocortical cells, Prostaglandins 11:753–767.

    Article  PubMed  CAS  Google Scholar 

  50. Laychock, S. G., Warner, W., and Rubin, R. P., 1977, Further studies on the mechanisms controlling prostaglandin biosynthesis in the cat adrenal cortex: The role of calcium and cyclic AMP, Endocrinology 100:74–81.

    Article  PubMed  CAS  Google Scholar 

  51. Inrie, R. C., Ramiah, T. R., Antoni, F., and Hutchinson, W. C., 1965, The effect of adrenocorticotrophin on the nucleic acid metabolism of the rat adrenal gland,J. Endocrinol. 32:303–313.

    Article  Google Scholar 

  52. Fuhrman, S. A., and Gill, G. N., 1974, Hormonal control of adrenal RNA polymerase activities, Endocrinology 94:691–700.

    Article  PubMed  CAS  Google Scholar 

  53. Fuhrman, S. A., and Gill, G. N., 1975, Adrenocorticotropic hormone stimulation of adrenal RNA polymerase I and III activities. Nucleotide incorporation into internal positions and 3′ chain termini, Biochemistry 14:2925–2933.

    Article  PubMed  CAS  Google Scholar 

  54. Fuhrman, S. A., and Gill, G. N., 1976, Adrenocorticotropic hormone regulation of adrenal RNA polymerases. Stimulation of nuclear RNA polymerase III, Biochemistry 15:5520–5527.

    Article  PubMed  CAS  Google Scholar 

  55. Saez, J. M., Morera, A. M., and Gallet, D., 1977, Opposite effects of ACTH and glucocorticoids on adrenal DNA synthesis in vivo, Endocrinology 100:1268–1275.

    Article  PubMed  CAS  Google Scholar 

  56. Ramachandran, J., and Suyama, A. T., 1975, Inhibition of replication of normal adrenocortical cells in culture by adrenocorticotropin, Proc. Natl. Acad. Sci. U.S.A. 72:113–117.

    Article  PubMed  CAS  Google Scholar 

  57. O’Hare, J. M., and Neville, A. M., 1973, Effects of adrenocorticotrophin on steroidogenesis and proliferation by adult adrenal cells in monolayer culture, Biochem. Soc. Trans. 1:1088–1091.

    Google Scholar 

  58. Weidman, E. R., and Gill, G. N., 1977, Differential effects of ACTH or 8-Br-cAMP on growth and replication in a functional adrenal tumor cell line, J. Cell. Physiol. 90:91–103.

    Article  PubMed  CAS  Google Scholar 

  59. Gill, G. N., and Weidman, E. R., 1977, Hormonal regulation of initiation of DNA synthesis and of differentiated function in Y-l adrenal cartical cells, J. Cell Physiol. 92:65–76.

    Article  PubMed  CAS  Google Scholar 

  60. Gospodarowicz, D., III, C. R. Hornsby, P. J., and Gill, G. N., 1977, Control of bovine adrenal cortical cell proliferation by fibroblast growth factor: Lack of effect of epidermal growth factor, Endocrinology 100:1080–1089.

    Article  PubMed  CAS  Google Scholar 

  61. Engeland, W. C., Shinsako, J., and Dallman, M. F., 1975, Corticosteroids and ACTH are not required for compensatory adrenal growth, Am. J. Physiol. 229:1461–1464.

    PubMed  CAS  Google Scholar 

  62. Engeland, W. C., and Dallman, M. F., 1975, Compensatory adrenal growth is neurally mediated, Neoroendocrinology 19:352–362.

    Article  CAS  Google Scholar 

  63. Dallman, M. F., Engeland, W. C., and Shinsako, J., 1976, Compensatory adrenal growth: A neurally mediated reflex, Am. J. Physiol. 231:408–414.

    PubMed  CAS  Google Scholar 

  64. Engeland, W. C., and Dallman, M. F., 1976, Neural mediation of compensatory adrenal growth, Endocrinology 99:1659–1662.

    Article  PubMed  CAS  Google Scholar 

  65. Lagerquist, L., and Tyler, F., 1976, Diagnosis and treatment of disorders of the adrenal cortex, Pharmacol. Ther. C 1:259–277.

    Google Scholar 

  66. Gwinup, G., and Johnson, B., 1975, Clinical testing of the hypothalamic-pituitary-adrenocortical system in states of hypo- and hypercortisolism, Metabolism 24:777–791.

    Article  PubMed  CAS  Google Scholar 

  67. Liddle, G. W., 1960, Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing’s syndrome,J. Clin. Endocrinol. Metab. 20:1539–1560.

    Article  PubMed  CAS  Google Scholar 

  68. Eddy, R. L., Jones, A. L., Gilliland, P. F., Ibarra, J. D., Jr., Thompson, J. Q., and Mc Murray, J. F., Jr., 1973, Cushing’s syndrome: A prospective study of diagnostic methods, Am. J. Med. 55:621–630.

    Article  PubMed  CAS  Google Scholar 

  69. Mattingly, D., and Tyler, C., 1976, Overnight urinary 11-hydroxycorticosteroid estimations in diagnosis of Cushing’s syndrome, Br. Med. J. 2:668–669.

    Article  PubMed  CAS  Google Scholar 

  70. Liddle, G. W., Estep, H. L., Kendall, J., Williams, W. C., Jr., and Townes, A. W., 1959, Clinical application of a new test of pituitary reserve, J. Clin. Endocrinol. Metab. 19:875–894.

    Article  PubMed  CAS  Google Scholar 

  71. Cheng, S. C., Harding, B. W., and Carballeira, A., 1974, Effects of metyra-pone on pregnenolone biosynthesis and on cholesterol-cytochrome P-450 interaction in the adrenal, Endocrinology 94:1451–1458.

    Article  PubMed  CAS  Google Scholar 

  72. Carballeira, A., Fishman, L. M., and Jacobi, J. D., 1976, Dual sites of inhibition by metyrapone of human adrenal steroidogenesis: Correlation of in vivo and in vitro studies,J. Clin. Endocrinol. Metab. 42:687–695.

    Article  PubMed  CAS  Google Scholar 

  73. Redman, J. F., and Faas, F. H., 1976, Acute unilateral adrenal hemorrhage following ACTH administration in a patient with Cushing’s syndrome, Am. J. Med. 61:533–536.

    Article  PubMed  CAS  Google Scholar 

  74. McKenna, T. J., Miller, R. B., and Liddle, G. W., 1977, Plasma pregnenolone and 17-OH-pregnenolone in patients with adrenal tumors, ACTH excess, or idiopathic hirsutism, J. Clin. Endocrinol. Metab. 44:231–236.

    Article  PubMed  CAS  Google Scholar 

  75. McKenna, T. J., Jennings, A. S., Liddle, G. W., and Burr, I. M., 1977, Pregnenolone, 17-OH-pregnenolone, and testosterone in plasma of patients with congenital adrenal hyperplasia,J. Clin. Endocrinol. Metab. 42:918–925.

    Article  Google Scholar 

  76. Kohlet, H., Blichert-Toft, M., Hancke, S., Pedersen, J. F., Kristensen, J. K., Efsen, F., Dige-Petersen, H., Fogh, J., Lockwood, K., and Hasner, E., 1976, Comparative study of ultrasound, 131I-19-iodocholesterol scintigraphy, and aortography in localising adrenal lesions, Br. Med. J. 2:665–667.

    Article  Google Scholar 

  77. Corrigan, D. F., Schaaf, M., Whaley, R. A., Czerwiński, C. L., and Earll, J. M., 1977, Selective venous sampling to differentiate ectopic ACTH secretion from pituitary Cushing’s syndrome, N. Engl. J. Med. 296:861–862.

    Article  PubMed  CAS  Google Scholar 

  78. Krieger, D. T., and Luria, M., 1977, Plasma ACTH and Cortisol responses to TRF, vasopressin or hypoglycemia in Cushing’s disease and Nelson’s syndrome,J. Clin. Endocrinol. Metab. 44:361–368.

    Article  PubMed  CAS  Google Scholar 

  79. Lagerquist, L. G., Meikle, A. W., West, C. D., and Tyler, F. H., 1974, Cushing’s disease with cure by resection of a pituitary adenoma, Am. J. Med. 57:826–830.

    Article  PubMed  CAS  Google Scholar 

  80. Tyrrell, J. B., Wiener-Kronish, J., Lorenzi, M., Brooks, R. M., and Forsham, P. H., 1977, Cushing’s disease: Growth hormone response to hypoglycemia after correction of hypercortisolism,J. Clin. Endocrinol. Metab. 44:218–221.

    Article  PubMed  CAS  Google Scholar 

  81. James, V. H. T., Landon, J., Wynn, V., and Greenwood, F. C., 1968, A fundamental defect in adrenocortical control in Cushing’s disease,J. Endocrinol. 40:15–28.

    Article  PubMed  CAS  Google Scholar 

  82. Hsu, T.-H., Hsu, C. K., and Gann, D. S., 1976, Potentiation of the ACTH response to metyrapone by L-Dopa in the monkey, Endocrinology 99:1115–1118.

    Article  PubMed  CAS  Google Scholar 

  83. Benker, G., Hackenberg, K., Hamburger, B., and Reinwein, D., 1976, Effects of growth hormone release-inhibiting hormone and bromocryptine (CB 154) in states of abnormal pituitary-adrenal function, Clin. Endocrinol. 5:187–190.

    Article  CAS  Google Scholar 

  84. Decker, R. E., Epstein, J. A., Carras, R., and Rosenthal, A. D., 1976, Transsphenoidal microsurgery for pituitary tumors: Experience with 45 cases, Mt. Sinai J. Med. N.Y. 43:565–577.

    CAS  Google Scholar 

  85. Ganguly, A., Stanchfield, J., Roberts, R., West, C., and Tyler, F., 1976, Cushing’s syndrome in a patient with an empty sella turcica and a microadenoma of the adenohypophysis, Am. J. Med. 60:306–309.

    Article  PubMed  CAS  Google Scholar 

  86. Lawrence, J. H., Tobias, C. A., Linfoot, J. A., Born, J. L., and Chong, C. Y., 1976, Heavy-particle therapy in acromegaly and Cushing’s disease, J. Am. Med. Assoc. 235:2307–2310.

    Article  CAS  Google Scholar 

  87. Cook, D. M., Jordan, R. M., Kendall, J. W., and Linfoot, J. A., 1976, Rapid appearance of transient secondary adrenocortical insufficiency after alpha-particle radiation therapy for Cushing’s disease, J. Clin. Endocrinol. Metab. 43:295–300.

    Article  PubMed  CAS  Google Scholar 

  88. Moore, T. J., Dluhy, R. G., Williams, G. H., and Cain, J. P., 1976, Nelson’s syndrome: Frequency, prognosis, and effect of prior pituitary irradiation, Ann. Intern. Med. 85:731–734.

    PubMed  CAS  Google Scholar 

  89. Krieger, D. T., and Luria, M., 1976, Effectiveness of cyproheptadine in decreasing plasma ACTH concentrations in Nelson’s syndrome, J. Clin. Endocrinol. Metab. 43:1179–1182.

    Article  PubMed  CAS  Google Scholar 

  90. Cassar, J., Doyle, F. H., Lewis, P. D., Mashiter, K., Van Noorden, S., and Joplin, G. F., 1976, Treatment of Nelson’s syndrome by pituitary implantation of yttrium-90 or gold-198, Br. Med. J. 2:269–272.

    Article  PubMed  CAS  Google Scholar 

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Gwynne, J.T., Ney, R.L. (1978). The Adrenal Cortex. In: Ingbar, S.H. (eds) The Year in Endocrinology 1977. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2502-4_5

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