Abstract
Genetic recombination involves the exchange of genetic material between chromosomes to produce new assortments of alleles. As such, it affects one of the most fundamental and important components of heredity, the genome itself. Genetic rearrangements can be favourable or unfavourable, and certain forms of cancer have been linked to gene translocations. To understand the molecular basis of recombination, we have directed our efforts to try to determine how simple organisms recombine their DNA. In bacteria and lower eukaryotes, the enzymes involved in genetic recombination also play a role in the repair of DNA following irradiation or chemical damage. This overlap between recombination and repair is indicative of a need for recombinational repair, a process which ensures that the integrity of the chromosomal material is maintained.
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© 1989 Plenum Press, New York
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West, S.C., Elborough, K.M., Parsons, C.A., Picksley, S.M. (1989). Proteins from Yeast and Human Cells Specific for Model Holliday Junctions in DNA. In: Lambert, M.W., Laval, J. (eds) DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells. NATO ASI Series, vol 182. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1327-4_22
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DOI: https://doi.org/10.1007/978-1-4684-1327-4_22
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