DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells

  • Muriel W. Lambert
  • Jacques Laval

Part of the NATO ASI Series book series (NSSA, volume 182)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Repair of Alkylation Damage in DNA

    1. Jacques Laval, Timothy O’Connor, Claudine d’Hérin-Lagravere, Patricia Auffret Van der Kemp, Serge Boiteux
      Pages 25-36
    2. Mutsuo Sekiguchi, Hiroshi Hayakawa, Ken-ichi Kodama, Kanji Ishizaki, Mituo Ikenaga
      Pages 73-81
    3. Rufus S. Day III, Junji Miyakoshi, Kelly Dobler, Joan Allalunis-Turner, John D. S. McKean, Kenneth Petruk et al.
      Pages 83-99
    4. Peter Karran, Janet Hall, Hiroko Kataoka, Claire Stephenson, Michael Green, Jill Lowe et al.
      Pages 101-108
    5. Janet Hall, Henriette Brésil, Ghyslaine Martel-Planche, Mireille Serres, Christopher P. Wild, Ruggero Montesano
      Pages 109-117
    6. Angelo Abbondandolo, Gabriele Aquilina, Margherita Bignami, Stefania Bonatti, Roberto Cosani, Eugenia Dogliotti et al.
      Pages 129-139
  3. Inducible Responses to DNA Damage

    1. Patricia Lefebvre, Francoise Laval
      Pages 141-148
    2. Bernd Kaina, Bernd Stein, Axel Schonthal, Hans Jobst Rahmsdorf, Helmut Ponta, Peter Herrlich
      Pages 149-165
  4. DNA Repair Related Events

    1. Walter G. Verly, Daniel Maréchal, Régis César
      Pages 167-169
    2. J. Rueff, A. Laires, A. Bras, H. Borba, T. Chaveca, J. Gaspar et al.
      Pages 171-181
  5. Mutagenesis

    1. Kenneth H. Kraemer, Saraswathy Seetharam, Douglas E. Brash, Anders Bredberg, Miroslava Protic’-Sabljic’, Michael M. Seidman
      Pages 183-193
    2. H. Vrieling, M. Z. Zdzienicka, J. W. I. M. Simons, P. H. M. Lohman, A. A. van Zeeland
      Pages 195-203
    3. Mary Mazur, Alasdair J. E. Gordon, Cecilia Bernelot-Moens, Barry W. Glickman
      Pages 205-210

About this book


This volume contains edited contributions from the speakers at the NATO Advanced Research Workshop on "DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells" held October 1-6, 1988, at the Abbaye Royale de Fontevraud, Fontevraud France. The meeting was dedicated to Paul Howard-Flanders (Yale University, New Haven, CT. , 1919-1988), whose seminal con­ tributions to the DNA repair field include the cO-discovery of the excision repair pathway, the elucidation of post-repli­ cation repair in E. coli, the isolation of the lexA and recC mutants, and his extensive work on the enzymology of RecA. A plethora of recent developments in DNA repair mechan­ isms and related processes in mammalian cells have advanced our understanding of this field in a number of different areas and have given new emphasis to the ways these systems both resemble DNA repair processes in other groups of organisms in some respects yet are strikingly different from them in others. Within the past decade there have been a number of international conferences on DNA damage and repair mechanisms but none has been focused on these processes in mammalian cells.


DNA DNA damage Nucleotide Purine Pyrimidine biological cells computed tomography (CT) development enzymology mutation oncogene protein synthesis transcription

Editors and affiliations

  • Muriel W. Lambert
    • 1
  • Jacques Laval
    • 2
  1. 1.New Jersey Medical SchoolUniversity of Medicine and Dentistry of New JerseyNewarkUSA
  2. 2.Institut Gustave RoussyVillejuifFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-1327-4
  • Copyright Information Springer-Verlag US 1989
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-1329-8
  • Online ISBN 978-1-4684-1327-4
  • About this book