Abstract
This paper deals with central and, to a lesser extent, peripheral cholinergic mechanisms which may be involved in some basic functional defects characterizing schizophrenia. To make these mechanisms intelligible it will be necessary, first, to describe the central cholinergic pathways, particularly those that may be pertinent for schizophrenia. Then, behavioral and functional correlates of these pathways that may be relevant for schizophrenia will be discussed. Finally, schizophrenic processes that may be dependent on behavioral correlates of cholinergic function will be emphasized, and an attempt will be made to explain these processes in terms of cholinergic deficits. The cholinergic functions that will be especially evaluated concern the arousal (reticular) and the limbic systems and their role in mentation as well as adaptive processes.
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References
Andersen, P., and Andersson, S. A., 1968, “Physiological basis of alpha rhythm,” Appleton-Century-Crafts, New York.
Arieti, S., ed., 1959, “American Handbook of Psychiatry, Vols. 1–2,” Basic Books, Inc., New York.
Arieti, S., ed., 1981, “American Handbook of Psychiatry, Vols. 7
Advances and New Directions,“ Basic Books, Inc., New York. Arieti, S., 1974,”Interpretation of Schizophrenia,“ 2nd ed., Basic Books, Inc., New York.
Arieti, S., 1959, Schizophrenia-other aspects; psychotherapy, in “American Handbook of Psychiatry, Vol. 1,” S. Arieti, ed., pp. 485–507, Basic Books, Inc., New York.
Arnold, M. B., 1960, “Emotion and Personality,” Columbia University Press, New York.
Barchas, J. D., Berger, P. A., Ciavanello, R. D., and Elliott, J. R., Jr., 1977, “Psychopharmacology,” pp. 197, Oxford University Press, New York.
Bell, D. S., 1965, Comparison of amphetamine psychosis and schizophrenia, Br. J. Psychiatry 3:701–707.
Berger, P. A., and Barchas, J. D., 1981, Biochemical hypothesis of schizophrenia, in “Basic Neurochemistry,” G. J. Siegel, R. Wayne Albers, B. W. Agranoff and R. Katzman, eds., pp. 759–774, Little, Brown and Co., Boston.
Bignami, G., 1976, Behavioral pharmacology and toxicology, Ann. Rev. Pharmacol. Toxicol. 16:329–366.
Bignami, G., and Rosic, N., 1976, The nature of disinhibitory phenomena caused by central cholinergic (muscarinic) blockade, in “Advances in Neuro-Psychopharmacology,” O. Vinar, Z. Votava and P. B. Bradley, eds., pp. 481–495, North Holland Publishing Co., Amsterdam.
Bleuler, E., 1924, “Textbook of Psychiatry,” MacMillan, New York. Bleuler, E., 1937, “Lehrbuch der Psychiatrie,” Springer-Verlag, Berlin.
Borbely, A. A., 1973, “Pharmacological modifications of evoked brain potentials,” Hans Huber Pubis., Bern.
Bovet, D., Bovet-Nitti, F., and Oliverio, A., 1966, Effects of nicotine on avoidance conditioning of inbred mice strains of mice, Psychopharmacologia 101: 1–5.
Buchsbaum, M. S., 1977, Psychophysiology and chizophrenia, Schizophr. Bull. 3:7–14.
Buchwald, N. A., Horvath, F. E., Wyers, E. J., and Wakefield, C., 1964, Electroencephalogram rhythm correlated with milk reinforcement in cats, Nature 201: 830–831.
Callaway, E., and Jones, R. T., 1969, Evoked responses to schizophrenic thinking, in “Neurophysiological and Behavioral Aspects of Psychotropic Drugs,” A. G. Karczmar and W. P. Koelle, eds., pp. 105–112, C. C. Thomas, Springfield, Illinois.
Carlton, P. L., 1968, Brain acetylcholine and habituation, Brain Res. 24:48–60.
Carroll, B. J., 1980, Neuroendocrine aspects of depression: theoretical and practical significance, in “Psychobiology of Affective Disorders,” J. Mendels and J. D. Amsterdam, eds., pp. 83–98, Karger, Basel.
Cheney, D. L., Racagni, E., and Costa, E., Appendix II: Distribution of acetylcholine and choline acetyltransferase in specific nuclei and tracts of rat brain, in “Biology of Cholinergic Function,” A. M. Goldberg and I. Hanin, eds., pp. 655–660, Raven Press, New York.
Clemente, D. C., Sterman, M. B., and Wyrwicka, W., 1964, Post-reinforcement EEG synchronization during alimentary behavior, Electroencephalogr. Clin. Neurophysiol. 16:355–365.
Davis, J. M., Janowsky, D., and Casper, R. L., 1977, Acetylcholine and mental disease, in “Neuro Regulators and Psychiatric Disorders,” E. Usdin, D. Hamburg and J. Barchas, eds., pp. 434–441, Oxford University Press, New York.
Domino, E. F., 1968, Cholinergic mechansism and the EEG, Electroencephalogr. Clin. Neurophysiol. 124:292–293.
Domino, E. F., Bartolini, A., and Kawamura, H., 1977, Effects of reticular stimulation, d-amphetamine and scopolamine on acetylcholine release from the hippocampus of brainstem transected cats, Arch. Int. Pharmacodyn. Ther. 225:294–302
Drachman, D. A., 1978, Central cholinergic system and memory, in “Psychopharmacology: A Generation of Progress,” M. A. Lipton, A.
DiMascio and K. F. Killam, eds., pp. 651–662, Raven Press, New York.
Duffy, F. H., and Burchfiel, J. L., 1980, Long term effects of the organophosphate sarin on EEG in monkeys and humans, Neurotoxicol. 1:667–689.
Fibiger, H. G., and Lehmann, J., 1981, Anatomical organization of some cholinergic systems in the mammalian forebrain, in “Cholinergic Mechanisms,” G. Pepeu and H. Ladinsky, eds., pp. 663–672, Plenum Press, New York.
Flor-Henry, P., 1979, On certain aspects of the localization of the cerebral systems regulating and determining emotion, Biol. Psychiatry 14:667–698.
Funkenstein, D. H., Greenblatt, M., and Solomon, H. C., 1949, Psychophysiology study of mentally ill patients, Part I - The status of the peripheral autonomic nervous sytem as determined by the reaction to epinephrine and mecholyl, Am. J. Psychiatry 106:16–28.
Garmezy, N., 1977, The psychology and psychopathology of attention, Schizophr. Bull. 3:360–369.
Glisson, S. N., Karczmar, A. G., Barnes, L., 1974, Effects of DFP on acetylcholine, cholinesterase and catecholamines of several rabbit brain parts, Neuropharmacology 13: 623–632.
Glowinski, J., and Karczmar, A. G., 1979, Interdependence of neurotransmitter system in the CNS, in “Neurotransmitters. Adv. Proc. VII Internatl. Congr. Pharmacol.,” P. Simon, ed., pp. 145–158, Pergamon Press, Oxford.
Guggenheimer, E. H., and Leringer, I. M., 1975, The effect of oxotremorine on the acetylcholine output from the CSF containing spaces, Experientia 31: 88–89.
Haase, H. J., 1965, Clinical observations on the action of neuroleptics, in “Actions of Neuroleptics, A Psychiatric, Neurologic and Pharmacological Investigation,” H. J. Haase and P. A. J. Janssen, eds., pp. 1–118, North Holland Publ. Co., Amsterdam.
Harris, C. M., Davis, J. M., and Janowsky, D. S., 1979, The use of cholinergic drugs in mental illness, in “Nutrition and the Brain, Vol. 5,” A. Barbeau, J. H. Growdon and R. J. Wurtman, eds., pp. 397–414, Raven Press, New York.
Heath, R. G., 1963, “Serological Fractions in Schizophrenia,” Hoeber, New York.
Hernândez-Peón, R., 1965, Central neurohumoral transmission in sleep and wakefulness, in “Progress in Brain Research Sleep Mechanisms,” K. Akert, C. Bally, and J. P. Schade, eds., pp. 96–116, Elsevier Publ., Amsterdam.
Hingtgen, J. N., and Aprison, M. H., 1976, Behavioral environmental aspects of the cholinergic system, in “Biology of Cholinergic Function,” A. M. Goldberg and I. Hanin, eds., pp. 515–566, Raven Press, New York.
Horvath, F., 1979, An experimental comparison of the psychological stress evaluation and the galvanic skin response in detection of deception, J. Appl. Psychol. 63:338–344
Hughes, R. N., 1982, A review of atropinic drug effects on exploratory choice behavior in laboratory rodents, Behay. Neural Biol. 35:5–41.
Itil, T., 1977, Qualitative and quantitative EEG findings in schizophrenia, Schizophr. Bull. 3:610–679.
Itil, T., and Fink, M., 1966, Anticholinergic drug-induced delirium: experimental modification, quantitative EEG and behavioral correlations, J. Nerv. Ment. Dis. 143:492–507.
Janowksy, D. S., Risch, C., Huey, L., Parker, D., Davis, J., and Judd, L., 1980, The cholinergic nervous system and depression, in “Psychobiology of Affective Disorders,” J. Mendels and J. D., Amsterdam, eds., pp. 83–98, Karger, Basel.
Jouvet, M., 1967, Neurophysiology of the states of sleep, in “The Neurosciences, A. Study Program,” G. C. Quarton, T. Melnechuk and F. U. Schmidt, eds., pp. 529–544, University Press, New York.
Jouvet, M., 1961, Telencephalic and rhombencephalic sleep in the cat, n “The Nature of Sleep,” G. E. W. Wolstenholme and M. O’Conner, eds., pp. 188–208, Churchill, London.
Karczmar, A. G., 1981b, Basic phenomena underlying novel use of cholinergic agents, anticholinesterases and precursors in neurological including peripheral and psychiatric disease, in “Cholinergic Synapses, Adv. in Behay. Biol., Vol. 25,” G. Pepeu and H. Ladinsky, eds., pp. 853–869, Plenum Press, New York.
Karczmar, A. G., 1979a, Brain acetylcholine and animal electrophysiology, in “Brain Acetylcholine and Neuropsychiatric Disease,” K. L. Davis and P. A. Berger, eds., pp. 265–310, Plenum Press, New York.
Karczmar, A. G., 1974, Brain acetylcholine and seizures, in “Psychobiology of Convulsive Therapy,” M. Fink, S. Kety, J. McGaugh and T. A. Williams, eds., pp. 251–270, V. H. Winston, Washington, D.C.
Karczmar, A. G., 1976, Central actions of acetylcholine, cholinomimetics and related drugs, in “Biology of Cholinergic Function,” A. M. Goldberg and I. Hanin, eds., pp. 395–449, Raven Press, New York.
Karczmar, A. G., 1982, Central effects of anticholinesterases with emphasis on behavior, sleep phenomena and psyche. Report for NAS Committee on Toxicology, National Research Council Anticholinesterase Panel, Washington, D.C.
Karczmar, A. G., 1975, Cholinergic influences on behavior, in “Cholinergic Mechanisms,” P. G. Waser, ed., pp. 501–529, Raven Press, New York.
Karczmar, A. G., 1977, Exploitable aspects of central cholinergic function, particularly with respect to the EEG, motor, analgesic and mental functions, in “Cholinergic Mechanisms and Psychopharmacology,” D. J. Jenden, ed., pp. 679–708, Plenum Press, New York.
Karczmar, A. G., 1981a, Multifactorial and multitransmitter basis of behaviors, and their cholinergic concomitants, Psychopharmacol. Bull. 17:68–70.
Karczmar, A. G., 1979b, Overview: Cholinergic drugs and behavior–what effects may be expected from a “cholinergic diet”? in “Nutrition and the Brain, Vol. 5,” A. Barbeau, J. H. Growdon and R. J. Wurtman, eds., pp. 141–175, Raven Press, New York.
Karczmar, A. G., 1967, Pharmacologic, toxicologic and therapeutic properties of anticholinesterase agents, in “Physiological Pharmacology, Vol. 3,” W. S. Root and F. G. Hofman, eds., pp. 163–322, Academic Press, New York.
Karczmar, A. G., Longo, V. G., and Scotti de Carolis, A., 1970, Pharmacological model of paradoxical sleep: the role of cholinergic and monoamine systems, Physiol. Behay. 5:175–182.
Karczmar, A. G., Scudder, C. L., and Richardson, D. L., 1973, Interdisciplinary approach to the study of behavior in related mice types, “Neuroscience Research, Vol. 5,” I. Kopin, ed., pp. 159–224, Academic Press, New York.
Kimura, H., McGeer, P. L., Peng, F., and McGeer, E. G., 1980, Choline acetyltransferase-containing neurons in rodent brain demonstrated by immunohistochemistry, Science 208: 1057–1059.
Kimura, N., McGeer, P. L., Peng, J. H., and McGeer, E. G., 1981, The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat. J. Comp. Neurol. 200:151–201.
Kindel, G., and Karczmar, A. G., 1981, Effect of single and repeated choline administration on brain choline, acetylcholine and acetylcholine turnover of CF-1 mice. Fed. Proc. 40–269.
Klawans, H. A., Jr., Westheimer, R., and Goetz, C. G., 1976, A pharmacological model of the pathophysiology of schizophrenia, Dis. Nerv. System 36:267–275.
Klemm, W. R., 1976, Physiological and behavioral significance of hippocampal rhythmic slow actrivity (Theta Rhythm), Prog. Neuropsychopharmacol. 6:23–47.
Koehn, G. L., and Karczmar, A. G., 1978, Effect of dispropylphosphofluoridate on analgesia and motor behavior in the rat, Prog. Neuropsychopharmacol. 2:169.
Koelle, G. B., 1963, Cytological distributions and physiological functions of cholinesterases, in “Cholinesterases and Anticholinesterase Agents, Hndbch. D. Exper. Pharmakol., Ereganzangswk, Vol. 15,” G. B. Koelle, ed., 187–298, Springer-Verlag, Berlin.
Kornetsky, C., and Hecht-Orzack, M., 1978, Physiological and behavioral correlates of attention dysfunction in schizophrenic patients, J. Psychiatr. Res. 4:69–79.
Kraepelin, E., 1913. “Psychiatrie, 8th Ed.,” V. J. Ambrosius Barth Verlag, Leipzig.
Kraepelin, E., 1919, (Transl. by R. M. Barclay), “Dementia Praecox and Paraphrenia,” E. S. Livingston, Edinburgh.
Krnjevic, K., 1976, Acetylcholine receptors in vertebrae CNS, in “Handbook of Psychopharmacology,” L. L. Iversen, S. D. Iversen and S. H. Snyder, eds., pp. 97–125, Plenum Press, New York.
Kupfer, D. J., and Edwards, D. J., 1978, Multitransmitter mechanisms and treatment of affective disease, in “Interrelationship Between Various Neurotransmitter Systems, Neuro-Psychopharmacology, Vol. 1,” A. G. Karczmar and J. Glowinski, eds., pp. 609–623, Pergamon Press, Oxford.
Lidsky, T. I., Weinhold, P. M., and Levin, F. M., 1979, Implications of basal ganglionic dysfunction for schizophrenia, Biol. Psychiatry 14:3–12.
Lidz, T., 1959, General concepts of psychosomatic medicine, in “American Handbook of Psychiatry, Vol. 1,” S. Arieti, ed., pp. 647–658, Basic Books, Inc., New York.
Longo, V. G., 1966, Mechanisms of the behavioral and electroencephalographic effects of atropine and related compounds, Pharmacol. Rev. 18:965–996.
Longo, V. G., and Loizzo, A., 1973, Effects of drugs on hippocampal 0-rhythm. Possible relationships to learning and memory processes in “Brain, Nerves and Synapses,” F. E. Bloom and G. H. Acheson, eds., pp. 46–54, Karger, Basel.
Longo, V. G., and Silvestrini, G., 1957, Action of eserine and amphetamine on the electrical activity of rabbit brain, J. Pharmacol. Exp. Ther. 120:160–170.
Magistrelli, G., and Karczmar, A. G., 1984, Effect of aggression versus losing fights on brain acetylcholine levels and turnover of CF-1 mice, Prog. Neuropsychopharmacol. (in press).
Magoun, H. W., 1952, An ascending reticular activating system in the brain stem, Arch. Neurol. Psychiat. 67:145–154.
Marczynski, T. J., 1971, Cholinergic mechanisms determines the occurrence of reward contingent positive variation (RCPV) in cat. Brain Res. 28: 71–83.
Marczynski, T. J., 1969, Invited discussion: Post-reinforcement synchronization and the cholinergic system, in “Symposium on Central Cholinergic Transmission and Its Behavioral Aspects,” A. G. Karczmar, ed., Fed. Proc. 28:132–134.
Marczynski, T. J., 1978, Neurochemical mechanisms in the genesis of slow potentials: A review and some clinical implications, in “Multidisciplinary Perspectives in Events Related to Brain Potential Research,” D. Otto, ed., pp. 25–35, U.S, Environmental Protection Agency, Washington, D.C.
Marczynski, T. J., 1967, Topical application of drugs to subcortical brain structures and selected aspects of electrical stimulation, Ergebn. d. Physiol. Biol. Chem. Exo,. Pharmacol. 59:86–159.
Marczynski, T. J., and Burns, L. L., 1976, Reward contingent positive variation (RCPV) and post-reinforcement EEG synchronization (PRS) in the cat: physiological aspects, the effects of morphine and LSD-25, and a new interpretation of cholinergic mechanisms, Gen. Pharmacol. 7:211–228.
Marczynski, T. J., Rosen, A. J., and Hackett, J. T., 1968, Reinforcement, electrocortical synchronization and facilitation of cortical auditory evoked potentials in appetitive instrumental conditioning, Electroencephalogr. Clin. Neurophysiol. 24:227–241.
McGeer, P. L., and McGeer, E. G., 1979, Central cholinergic pathways, in “Choline and Lecithin in Brain Disorders, Nutrition and Brain, Vol. 5,” A. Barbeau, J. H. Growdon, and R. J. Wurtman, eds., pp. 177–198, Raven Press, New York.
McKenna, T., McCarley, R. W., Amatruda, T., Black, D., and Hobson, J. A., 1974, Effects of carbachol at pontine sites yielding long duration desynchronized sleep episodes, in “Sleep Research, Vol. 3,” M. H. Chase, W. C. Stern and P. L Walter, eds., p. 35, BIS/BRI, Los Angeles.
Mednick, S. A., and Schulsinger, F., 1970, Factors related to breakdown in children at high risk in schizophrenia, in “Life History Research in Psychopathology,” M. Roff and D. F. Ricks, eds., pp. 51–93, University of Minnesota Press, Minneapolis.
Metcalf, D. R., and Holmes, J. H., 1969, EEG, psychological, and neurological alterations in humans with or without organophosphate exposure, Ann. N.Y. Acad. Sci. 160:357–365.
Michaels, J. J., 1959, Character structure and character disorders, in “American Handbook of Psychiatry, Vol. 1,” S. Arieti, ed., pp. 353–377, Basic Books, New York.
Monnier, M., Kalberer, M., and Krupp, P., 1960, Functional antagonism between diffuse reticular and intralaminary recruiting projections in the medial thalamus, Exp. Neurol. 2:271–289.
Montplaisir, J. Y., 1975, Cholinergic mechanisms involved in cortical activation during arousal, Electroencephalogr. and Clin. Neurophysiol. 38:263–272.
Morley, B. J., Robinson, G. R., Brown, G. B., Kemp, G. E., and Bradley, R. J., 1977 Effects of dietary choline on nicotinic acetylcholine receptors in the brain, Nature 266: 848–850.
Myers, R. S., 1974, “Handbook of Drug and Chemical Stimulation of the Brain,” Reinhold, New York.
Neubauer, H., Adams, M., and Redfrom, P., 1975, The role of central cholinergic mechanisms in schizophrenia, Med. Hypotheses 1:32–34.
Nicoll, R. A., 1975, The action of acetylcholine antagonists on amino acid responses in the frog spinal cord, Br. J. Pharmacol. 55:449–458.
Nishi, S., Minota, S., and Karczmar, A. G., 1974, Primary afferent neurons: the ionic mechanism of GABA-mediated depolarization, Neuropharmacology 13: 215–220.
Olds, J., 1958, Self-stimulation on the brain. Its use to study local effects of hunger, sex and drugs, Science 127: 315–324.
Pepeu, G., 1973, The release of acetylcholine from the brain: an approach to the study of the central cholinergic mechanisms, Prog. Neurobiol. 2:259–288.
Pfefferbaum, A., Davis, K. L., Coulter, C. L., Mohr, R. C., and Kopell, B. S., 1979, Electrophysiological effects of physostigmine in humans, in “Brain Acetylcholine and Neuropsychiatric Disease,” K. L. Davis and P. A. Berger, eds., pp. 345–360, Plenum Press, New York.
Pfeiffer, C. C., and Jenney, E. H., 1957, The inhibition of the conditioned response and the counteraction of schizophrenia by muscarinic stimulation of the brain, Ann. N.Y. Acad. Sci. 66:753–764.
Phillis, J. W., and York, D. H., 1968, Pharmacological studies on a cholinergic inhibition in the cerebral cortex, Brain Res. 10:297–306.
Pribram, K. H., and Isaacson, R. L., 1975, “The Hippocampus, Vol. 2,” pp. 429–441, Plenum Press, New York.
Pribram, K. H., and McGuiness, D., 1975, Arousal, activation and effort in the control of attention, Psychol. Rev. 82:116–140.
Randic, M., Siminoff, R., and Straughan, D. W., 1964, Acetylcholine depression of the cortical neurons, Exp. Neurol. 9:236–242.
Richardson, D. L., and Karczmar, A. G., 1981, Effect of stress on avoidance conditioning and neurotransmitters, J. Amer. Osteo. Assoc. 62:68.
Rinaldi, R., and Himwich, H., 1955, Cholinergic mechanisms involved in function of mesodiencephalic activating system, Arch. Neurol. Psychiatry 73:394–402.
Roemer, R. A., Shagass, C., Straumanis, J. J., and Amadeo, M., 1978, Pattern evoked potential measurements suggesting lateralized hemispheric dysfunction in chronic schizophrenics, Biol. Psychiatry 13:185–202.
Roemer, R. A., Shagass, C., Straumanis, J. J., and Amadeo, M., 1979, Somatosensory and auditory evoked potential studies of functional differences between the cerebral hemispheres in psychosis, Biol. Psychiatry 14:357–373.
Rosenthal, R., and Bigelow, L. G., 1973, The effects of physostigmine in phenothiazine resistant chronic schizophrenic patients: preliminary observations, Compr. Psychiatry 14:489–495.
Roth, R. H., and Bunney, B. S., 1976, Interaction of cholinergic neurons, with other chemically defined neuronal systems in CNS, in “Biology of Cholinergic Function,” A. M. Goldberg and I. Hanin, eds. pp. 379–394, Raven Press, New York.
Rubin, L. S., and Barry, T. J., 1970, Disautonomia in schizophrenic remission, Psychosomatics 11: 506–512.
Sachar, E. J., 1981, Psychobiology of schizophrenia, in “Principles of Neural Science,” E. R. Kandel and J. H. Schwartz, eds., pp. 599–610, Elsevier-North Holland, Amsterdam.
Saelens, J. K., and Simke, J. P., 1976, Appendix IV: Effects of various drugs on acetylcholine and choline concentrations in various biological tissues, in “Biology of Cholinergic Functions,” A. M. Goldberg and I. Hanin, eds., pp. 683–706, Raven Press, New York.
Schmidt, D. W., and Wecker, L., 1981, CNS effects of choline administration: evidence for temporal dependence, Neuropharmacology 20:535–539.
Shagass, C., 1968, Averaged somatosensory evoked responses in various psychiatric disorders, in “Recent Advances in Biological Psychiatry, Vol. 10,” J. Wortis, ed., pp. 205–219, Plenum Press, New York.
Shagass, C., 1977, Early evoked potentials, Schizophr. Bull. 3:80–92.
Shakow, D., 1962, Segmental set, Arch. Gen. Psychiatry 6:1–17.
Shakow, D., 1967, Understanding normal psychological function, contributions from schizophrenia, Arch. Gen. Psychiatry 17:306–319.
Shattock, M. F., 1950, The somatic manifestations of schizophrenia. A clinical study of their significance, J. Ment. Sci. 96:32–142.
Shinnick-Gallagher, P., Gallagher, J. P., and Yoshimura, M., 1984, The pharmacology of sympathetic preganglionic neurons, in “Ganglionic Transmission in Vertebrates,” A. G. Karczmar, K. Koketsu and S. Nishi, eds., Karger Publs., Basel, (in press).
Shute, C. C. D., and Lewis, P. R., 1975, Cholinergic pathways I. Histochemical localization, Pharmacol. Ther. 1:79–87.
Singh, M. M., and Kay, S. R., 1979, Therapeutic antagonism between anticholinergic anti-Parkinsonism agents and neuroleptics in schizophrenia. Implications for a neuropharmacological model. Neuropsychobiol. 5: 74–78.
Singh, M. M., and Kay, S. R., 1975, Therapeutic reversal with benztropine in schizophrenics - practical and theoretical significance, J. Nerv. Ment. Dis. 160:258–266.
Singh, M. M., and Lal, 1982, Central cholinergic mechanisms, neuroleptic actions and schizophrenia, in “Clinical Application in Neuropharmacology,” W. B. Essman and L. Valzelli, eds., pp. 337–389, Spectrum Publications, New York.
Singh, M. M., and Lal, H., 1979, Dysfunctions of cholinergic processes in schizophrenia, in “Biological Psychiatry Today Vol. 2A,” pp. 434–438, Proc. 2nd World Congress Biological Psychiatry.
Sitaram, N., Moore, A. M., Varskiver, C., Blendy, J., Nurnberger, J. I., Jr., Gershon, E. S., and Gillin, J.C., 1981, Hypersensitive cholinergic functioning in primary affective illnesses, in “Cholinergic Mechanisms,” G. Pepeu and H. Ladinsky, eds., pp. 947–962, Plenum Press, New York.
Sitaram, N., Wyatt, R. J., Dawson, S., and Gillin, J. C., 1976, REM sleep induction by physostigmine infusion during sleep, Science 191:1281–1282.
Stadler, H., Lloyd, K. G., Gadea-Ciria, M., and Bartolini, G., 1973, Enhanced striatal acetylcholine release by chlorpromazine and its reversal by apomorphine, Brain Res. 55: 476–480.
Stein, L., 1968, Chemistry of reward and punishment, in “Psychopharmacology: A Review of Progress 1957–1967,” D. H. Efron, J. 0. Cole, J. Levine, and J. R. Wittenborn, eds., pp. 105–123, U.S. Govt. Printing Office, Washington, D.C.
Steriade, M., and Hobson, J. A., 1976, A neuronal activity during the sleep-waking cycle, Prog. Neurobiol. 6:155–376.
Szelenberger, W., 1979, Visual evoked response modified recovery cycle and personality dimensions in healthy schizophrenia subjects, Biol. Psychiatry 14:141–153.
Szerb, J. C., 1979, in “Presynaptic Receptors,” S. Z. Langer, K. Starke and M. L. Dubcovich, eds., pp. 293–398, Pergamon Press, Oxford.
Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M., 1976, Depression associated with choline, Lancet p.905.
Van Meter, W. G., 1969, Central nervous system responses to anticholinesterases in rabbits: evidence for a non-inhibitory action and for an adrenergic link, Ph.D. Thesis, Loyola University, Chicago.
Van Meter, W. G., and Karczmar, A. G., 1973, Unpublished data.
Van Meter, W. G., and Fiscus, R. R., 1978, CNS effects of anticholinesterases, Arch. Int. Pharmacodyn. Ther. 23:249–260.
Van Woert, M. H., 1976, Myasthenia Gravis, Eaton Lambert Syndrome and Familial Dysautonomia, in “Biology of Cholinergic Function,” A. M. Goldberg and I. Hanin, eds., pp. 567–577, Raven Press, New York.
Weiss, B. L., Foster, F. G., and Kupper, D. J., 1976, Cholinergic involvement in neuropsychiatric disorders, in “Biology of Cholinergic Function,” A. M. Goldberg and I. Hanin eds., pp. 603–617, Raven Press, New York.
Wikler, A., 1952, Pharmacologic dissociation of behavior and EEG sleep patterns in dogs: Morphine n-allyl normorphine and atropine, Proc. Soc. Exp. Biol. Med. 79:261–265.
Williams, R. B., Frankel, B. L., Gillin, J.C., and Weiss, J. L., 1973, Cardiovascular response during a word association test and an interview, Psychophysiology 1: 571–577.
Williams, R. B., Bittker, T. E., Buchsbaum, M. S., and Wynne, L. C., 1975, Cardiovascular and neurophysiological correlates of sensory intake and rejection. I. Effect of cognitive tasks, Psychophysiology 12: 427–433.
Zahn, T. P., 1975 Psychophysiological concomitants of task performance in schizophrenia, in “Experimental Approaches to Psychopathology,” 12: 427–433.
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Karczmar, A.G., Richardson, D.L. (1985). Cholinergic Mechanisms, Schizophrenia, and Neuropsychiatric Adaptive Dysfunctions. In: Singh, M.M., Warburton, D.M., Lal, H. (eds) Central Cholinergic Mechanisms and Adaptive Dysfunctions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1218-5_7
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