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Pharmacology of Antineoplastic Agents in Cerebrospinal Fluid

  • Chapter
Neurobiology of Cerebrospinal Fluid 1

Abstract

The treatment of central nervous system malignancy represents one of the single greatest challenges in the field of cancer medicine. The great strides in the treatment of extracerebral malignancy achieved in the past two decades have not been accompanied by an appreciable improvement in the treatment of intracerebral malignancies, either primary or metastatic. Now that effective therapy is available for acute lymphocytic leukemia, brain tumors are emerging as the most common cause of nonaccidental death in children over 6 months of age. In adults, malignant glioma, the most common brain tumor, remains a lethal disease in almost all of affected individuals. Also, the number of patients with central nervous system metastases from systemic cancer continues to increase (Table 1), mainly because the risk of central nervous system infiltration in such patients appears to be directly proportional to the duration of survival. As survival has increased, so has the incidence of central nervous system metastases. Ironically, success in the treatment of systemic malignancy has created a new problem, one that underscores the need for more effective therapy for central nervous system neoplasia.

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Authors and Affiliations

  1. Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205, USA

    David G. Poplack M.D. & Marc E. Horowitz M.D.

  2. Division of Hematology-Oncology, Department of Pediatrics, Children’s Orthopedic Hospital Medical Center, Seattle, Washington, 98105, USA

    W. Archie Bleyer M.D.

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  1. David G. Poplack M.D.
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  2. Marc E. Horowitz M.D.
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  3. W. Archie Bleyer M.D.
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Editors and Affiliations

  1. Division of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    James H. Wood M.D. (Consultant) (Consultant)

  2. Pediatric Oncology Branch, National Cancer Institute National National Institutes of Health, Bethesda, Maryland, 20205, USA

    James H. Wood M.D. (Consultant) (Consultant)

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© 1980 Plenum Press, New York

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Poplack, D.G., Horowitz, M.E., Bleyer, W.A. (1980). Pharmacology of Antineoplastic Agents in Cerebrospinal Fluid. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1039-6_39

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  • DOI: https://doi.org/10.1007/978-1-4684-1039-6_39

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