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Chemical Alterations of Cerebrospinal Fluid Acting on Respiratory and Circulatory Control Systems

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Neurobiology of Cerebrospinal Fluid 1

Abstract

Electron microscopy has revealed that the extracellular spaces of the brain are open to the subarachnoid space.18 Free exchange of substance has been demonstrated for nonelectrolytes such as inulin,81 for ampholytes such as horseradish peroxidase,18 and for charged particles such as potassium ions.15,44 Molecular size of the particle and its charge do not prevent exchange between the cerebrospinal fluid (CSF) and the extracellular space. Thus, this exchange occurs by diffusion 74 and possibly by local convection currents. The movement of the head causes mechanical distortions of the brain and may “pump” fluid from regions of momentarily high pressure to areas of lower pressure.107,108 The ciliary movements of the ependyma may also contribute to such exchange.70,107

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References

  1. Ahmad, H. R., Berndt, J., Loeschcke, H. H.: Bicarbonate exchange between blood, brain extracellular fluid and brain cells at maintained pCO2. In Loeschcke, H. H. (ed.): Acid-Base Homeostasis of the Brain Extracellular Fluid and the Respiratory Control System. Stuttgart, Georg Thieme, 1976, pp. 19–27.

    Google Scholar 

  2. Ahmad, H. R., Loeschcke, H. H., Woidtke, H. H.: Three compartments model for the bicarbonate exchange of the brain extracellular fluid with blood and cells. In Fitzgerald, S., Gautier, H., Lahiri, S. (eds.): The Regulation of Respiration during Sleep and Anesthesia, Advances in Experimental Medicine and Biology, Vol. 99, New York and London, Plenum Press, 1977, pp. 195–209.

    Google Scholar 

  3. Amendt, K., Czachurski, J., Dembrovsky, K., Seller, H.: Neurones within the “chemosensitive area” on the ventral surface of the brainstem which project to the intermediolateral column. Pfluegers Arch.375:289–292, 1978.

    Google Scholar 

  4. Bekaert, J., Leusen, I.: Au sujet de l’influence res piratoire de l’injection sousoccipitale de lobeline. Schweiz. Med. Wochenschr.80:1236, 1950.

    Google Scholar 

  5. Berndt, J., Berger, W., Berger, K., Schmidt, M.: Untersuchungen zum zentralen chemosensiblen Mechanismus der Atmung. II. Die Steuerung der Atmung durch das extrazellulare pH im Gewebe der Medulla oblongata, Pfluegers Arch. Physiol.332:146–170.

    Google Scholar 

  6. Berndt, J., Berger, W., Trouth, C. O.: Respiratory and circulatory effects of 100 meq/l potassium or 2% procaine in the cerebrospinal fluid of cats. Pfluegers Arch.321:346–363, 1970.

    Google Scholar 

  7. Bisset, G. W., Feldberg, W., Guertzenstein, P. G., Rcocha E Silva, M., Jr.: Vasopressin release by nicotine: The site of action. Br. J. Pharmacol.54:463–474, 1975.

    Google Scholar 

  8. Bloom, F. E., Segal, D. S.: Endorphins in cerebrospinal fluid. In Wood, J. H. (ed.): Neurobiology of Cerebrospinal Fluid I. New York, Plenum Press, 1980.

    Google Scholar 

  9. Borison, H. L., Haranath, P. S. R. K., Mccarthy, L. E.: Respiratory responses to chemical pulses in the cerebrospinal fluid. Br. J. Pharmacol.44:605–616, 1972.

    Google Scholar 

  10. Borison, H. L., Wang, S. C: Physiology and pharmacology of vomiting. Pharmacol. Rev.5:193–230, 1953.

    Google Scholar 

  11. Bousquet, P., Guertzenstein, P. G.: Localization of the central cardiovascular action of clonidine. Br. J. Pharmacol.49:573–579, 1973.

    Google Scholar 

  12. Bouverot, P., Flandrois, R., Puccinelli, R., Dejours, P.: Etude du role des chemorecepteurs arteriels dans la regulation de la respiration pulmonaire chez le chien éveillé. Arch. Int. Pharmacodyn.157:253–271, 1965.

    Google Scholar 

  13. Carraway, R., Leeman, G. E.: The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami, J. Biol. Chem.248:6854–6861, 1973.

    Google Scholar 

  14. Catt, K. J., Dufau, M. L.: Peptide hormone receptors. Annu. Rev. Physiol.39:529–557, 1977.

    Google Scholar 

  15. Cragg, P., Patterson, L., Purves, M. J.: The pH of brain extracellular fluid in the cat. J. Physiol.272:137–166, 1977.

    Google Scholar 

  16. Cserr, H.: Potassium exchange between cerebrospinal fluid, plasma and brain, Am. J. Physiol.209:1219–1226, 1965.

    Google Scholar 

  17. Davson, H.: Physiology of the Cerebrospinal Fluid. London, Churchill, 1967.

    Google Scholar 

  18. de Bersaques, J., Leusen, I. R.: The direct influence of ammonium chloride on the respiratory system, Arch. Int. Pharmacodyn.97:13–16, 1954.

    Google Scholar 

  19. Dermietzel, R.: Central chemosensitivity: Morphological studies. In Loeschcke, H. H. (ed.): Acid-Base Homeostasis of the Brain Extracellular Fluid and the Respiratory Control System. Stuttgart, Georg Thieme, 1976, pp. 52–65.

    Google Scholar 

  20. Dev, N. B., Loeschcke, H. H.: Topography of the respiratory and circulatory responses to acetylcholine and nicotine on the ventral surface of the medulla oblongata. Pfluegers Arch. Physiol.379:19–27, 1979.

    Google Scholar 

  21. Dev, N. B., Loeschcke, H. H.: A cholinergic mechanism involved in the respiratory chemosensitivity of the medulla oblongata in the cat. Pfluegers Arch. Physiol.379:29–36, 1979.

    Google Scholar 

  22. Dey, P. K., Feldberg, W.: Analgesia produced by morphine when acting from the liquor space. Br. J. Pharmacol. Chemother.58:383–394, 1976.

    Google Scholar 

  23. Feldberg, W.: The ventral surface of the brain stem: A scarcely explored region of pharmacological sensitivity. Neuroscience1:427–441, 1976.

    Google Scholar 

  24. Feldberg, W., Guertzenstein, P. G.: A vasedepressor effect of pentobarbitone sodium. J. Physiol.224:83–103, 1972.

    Google Scholar 

  25. Feldberg, W., Guertzenstein, P. G.: Vasedepressor effects obtained by drugs acting on the ventral surface of the brain stem. J. Physiol.258:337–355, 1976.

    Google Scholar 

  26. Feldberg, W., Hellong, R. F., Myers, R. D.: Effects on temperature of monoamines injected into the cerebral ventricles of anaesthetized dogs. J. Physiol.186:416–423, 1966.

    Google Scholar 

  27. Feldberg, W., Myers, R. D., VEALE, W L.: Perfusion from cerebral ventricle to cisterna magna in the unanaesthetized cat: Effect of calcium on body temperature. J. Physiol.207:403–416, 1970.

    Google Scholar 

  28. Feldberg, W., Saxena, P. N.: Further studies on prostaglandin E1 fever in cats. J. Physiol.219:739–745, 1971.

    Google Scholar 

  29. Fencl, V., Miller, T. B., Pappenheimer, J. R.: Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid. Am. J. Physiol.210:459–472, 1966.

    Google Scholar 

  30. Fencl, V., Vale, J. R., Broch, J. A.: Respiration and cerebral blood flow in metabolic acidosis and alkalosis in humans. J. Appl. Physiol.27:67–76, 1969.

    Google Scholar 

  31. Folgering, H., Rutten, F., Agoston, S.: Stimulation of ventilation by an acetylcholine releasing drug: 4-aminopyridine, Pfluegers Arch. Physiol.379:181–185, 1979.

    Google Scholar 

  32. Fukuda, Y., Loeschcke, H. H.: Effect of H+ on spontaneous neuronal activity in the surface layer of the rat medulla oblongata in vitro. Pfluegers Arch.371:125–134, 1977.

    Google Scholar 

  33. Fukuda, Y., Loeschcke, H. H.: A cholinergic mechanism involved in the neuronal excitation by H+ in the respiratory chemosensitive structures of the ventral medulla oblongata of rats in vivo. Pfluegers Arch.379:125–135, 1979.

    Google Scholar 

  34. Gesell, R., Brassfield, C. R., Hamilton, M. A.: An acid-neurohumoral mechanism of nerve cell activation. Am. J. Physiol.136:604–608, 1942.

    Google Scholar 

  35. Gesell, R., Hansen, E. T.: Eserine, acetylcholine, atropine and nervous integration. Am. J. Physiol.139:371–385, 1943.

    Google Scholar 

  36. Gesell, R., Hansen, E. T.: Anticholinesterase activity as a biological instrument of nervous integration. Am. J. Physiol.144:126–163, 1945.

    Google Scholar 

  37. Guillemin, R.: Peptides in the brain: The new endocrinology of the neuron. Science202:390–402, 1978.

    Google Scholar 

  38. Hatcher, R. A., Weiss, S.: Studies on vomiting, J. Pharmacol. Exp. Ther.22:139–193, 1923.

    Google Scholar 

  39. Hilton, S. M.: Ways of viewing the central nervous control of the circulation—old and new. Brain Res.87:213–219, 1975.

    Google Scholar 

  40. Hori, T., Roth, G. I., Yamamoto, W. S.: Respiratory sensitivity of rat brain-stem surface to chemical stimuli. J. Appl. Physiol.28:721–724, 1970.

    Google Scholar 

  41. Hughes, J.: Les morphines du cerveau. Recherche93:866–875, 1978.

    Google Scholar 

  42. Jouvet, M.: The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle. Ergeb. Physiol.64:166–307, 1972.

    Google Scholar 

  43. Kalow, W.: Hydrolysis of local anaesthetics by human serum-cholinesterase. J. Pharmacol. Exp. Ther.104:122–134, 1952.

    Google Scholar 

  44. Katsaros, B.: Die Rolle der Chemoreceptoren des Carotisgebiets der narkotisierten Katze für die Antwort der Atmung auf isolierte Änderung der Wasserstoffionen-Konzentration und des CO2-Drucks des Blutes. Pfluegers Arch.282:157–178, 1965.

    Google Scholar 

  45. Katzman, R., Graziani, L., Ginsburg, S.: Cation exchange in blood, brain and CSF. In Lajtha, A., Ford, D. H. (eds.): Brain Barrier Systems, Progress in Brain Research. Amsterdam, London, New York, Elsevier, 1968, pp. 283–293.

    Google Scholar 

  46. Kazemi, H., Javaheri, S.: Interaction between Pco2 and plasma HCO3− in regulation of CSF HCO3− in respiratory alkalosis and metabolic acidosis. In Fitzberald, R., Gautier, H., Lahiri, S. (eds.): The Regulation of Respiration during Sleep and Anesthesia, Advances in Experimental Medicine and Biology, Vol. 99, New York and London, Plenum Press, 1978, pp. 173–183.

    Google Scholar 

  47. Kazemi, H., Weyne, J., van Leuven, F., Leusen, I.: The CSF HCO3− increase in hypercapnia: Relationship to HCO3−, glutamate, glutamine and NH3 in brain. Respir. Physiol.28:338–401, 1976.

    Google Scholar 

  48. Koelle, G. B.: The histochemical localization of cholinesterase in the central nervous system of the cat. J. Comp. Neurol.100:211–235, 1954.

    Google Scholar 

  49. Leusen, I.: Chemosensitivity of the respiratory center: Influence of CO2 in the cerebral ventricles on respiration. Am. J. Physiol176:39–44, 1954.

    Google Scholar 

  50. Leusen, I.: Chemosensitivity of the respiratory center: Influence of changes in the H+ and total buffer concentrations in the cerebral ventricles on respiration. Am. J. Physiol.176:45–51, 1954.

    Google Scholar 

  51. Leusen, I.: Regulation of cerebrospinal fluid composition with reference to breathing. Physiol. Rev.52:1–56, 1972.

    Google Scholar 

  52. Leusen, I., Demeester, G.: Acid-base balance in cerebrospinal fluid during prolonged artificial hyperventilation. Arch. Int. Physiol. Biochem.72:721–724, 1964.

    Google Scholar 

  53. Leusen, I., Lacrois, E., Demeester, G.: Lactate and pyruvate in the brain of rats during changes in acid-base balance. Arch. Int. Physiol. Biochem.75:310–324, 1967.

    Google Scholar 

  54. Loeschcke, H. H.: A concept of the role of intracranial chemosensitivity in respiratory control. In Brooks, MC, Kao, F. F., Lloyd, B. B. (eds.): Cerebrospinal Fluid and the Regulation of Ventilation. Oxford, Blackwell, 1965, pp. 183–207.

    Google Scholar 

  55. Loeschcke, H. H.: Central nervous chemoreceptors. In Guyton, A. C., Widdicombe, J. G. (eds.): Medical and Technical Publishing Co. International Review of Science, Respiratory Physiology, Physiology Series I, Vol. 2, University Park Press, Baltimore, 1974, pp. 167–196.

    Google Scholar 

  56. Loeschcke, H. H., DE Lattre, J., Schlaefke, M. E., Trouth, C. O.: Effects on respiration and circulation of electrically stimulating the ventral surface of the medulla oblongata. Respir. Physiol.10:184–197, 1970.

    Google Scholar 

  57. Loeschcke, H. H., Katsaros, B.: Die Wirkung von in den Liquor cerebrospinalis eingebrachtem Ammoniumchlorid auf Atmung und Vasomotorik. Pfluegers Arch.270:147–160, 1959.

    Google Scholar 

  58. Loeschcke, H. H., Koepchen, H. P.: Über das Verhalten der Atmung und des arteriellen Drucks bei Einbringen von Veratridin, Lobelin und Cyanid in den Liquor cerebrospinalis. Pfluegers Arch. Physiol.266:586–610, 1958.

    Google Scholar 

  59. Loeschcke, H. H., Koepchen, H. P.: Beeinflussung von Atmung und Vasomotorik durch Einbringen von Novocain in die Liquorraume. Pfluegers Arch. Physiol.266:611–627, 1958.

    Google Scholar 

  60. Loeschcke, H. H., Koepchen, H. P.: Versuch zur Lokalisation des Angriffsortes der Atmungs-und Kreislaufwirkung von Novocain im Liquor cerebrospinalis, Pfluegers Arch. Physiol.226:628–641, 1958.

    Google Scholar 

  61. Loeschcke, H. H., Koepchen, H. P., Gertz, K. H.: Uber den Einfluss von Wasserstoffionenkonzentration und CO2-Druck im Liquor cerebrospinalis auf die Atmung, Pfluegers Arch.266:569–585, 1958.

    Google Scholar 

  62. Loeschcke, H. H., Schlaefke, M. E.: Central chemosensitivity. In Paintal, A. S. (ed.): Morphology and Mechanisms of Chemoreceptors. Delhi, Vallabhbhai Patel Chest Institute, University of Delhi, 1977, pp. 282–296.

    Google Scholar 

  63. Loeschcke, H. H., Sugioka, K.: pH of cerebrospinal fluid in the cisterna magna and on the surface of the choroid plexus of the 4th ventricle and its effect on ventilation in experimental disturbances of acid base balance: Transients and steady states. Pfluegers Arch.312:161–188, 1969.

    Google Scholar 

  64. Maren, T. H.: Carbonic anhydrase: Chemistry, physiology and inhibition. Physiol. Rev.47:595–781, 1967.

    Google Scholar 

  65. Marino, P. L., Lamb, T. W.: Effects of CO2 and extracellular H+ iontophoresis on single cell activity in the cat brainstem. J. Appl. Physiol.38:688–695, 1975.

    Google Scholar 

  66. Mitchell, R. A.: The regulation of respiration in metabolic acidosis and alkalosis. In Brooks, McC., Kao, F. F., Lloyd, B. B. (eds.): Cerebrospinal Fluid and the Regulation of Ventilation, Oxford, Blackwell, 1965, pp. 109–131.

    Google Scholar 

  67. Mitchell, R. A., Herbert, D. A.: The effect of carbon dioxide on the membrane potential of medullary respiratory neurons. Brain Res.75:345–349, 1974.

    Google Scholar 

  68. Mitchell, R. A., Loeschcke, H. H., Massion, W. H., Severinghaus, J. W.: Respiratory responses mediated through superficial chemosensitive areas on the medulla. J. Appl. Physiol.18:523–533, 1963.

    Google Scholar 

  69. Mitchell, R. A., Loeschcke, H. H., Severinghaus, J. W., Richardson, B. W., Massion, W. H.: Regions of respiratory chemosensitivity on the surface of the medulla. Ann. N. Y. Acad. Sci.109:661–681, 1963.

    Google Scholar 

  70. Nattie, E. E., Romer, L.: The role of chloride and other anions in cerebrospinal fluid bicarbonate regulation. In Fitzgerald, S., Gautier, H., Lahiri, S. (eds.): The Regulation of Respiration during Sleep and Anesthesia, Advances in Experimental Medicine and Biology, Vol. 99, New York and London, Plenum Press, 1977, pp. 211–218.

    Google Scholar 

  71. Nelson, D. J., Wright, E. M.: The distribution, activity and function of the cilia in the frog brain. J. Gen. Physiol.243:63–78, 1974.

    Google Scholar 

  72. Nicholson, H. C., Sobin, S.: Respiratory effects from application of cocaine, nicotine and lobeline to the floor of the fourth ventricle. Am. J. Physiol.123:766–774, 1938.

    Google Scholar 

  73. Nicoll, R. A., Siggins, G., Ling, N., Bloom, F., Guillemin, R.: Neuronal actions of endorphins and enkephalins among brain regions—comparative microiontophoretic study. Proc. Natl. Acad. Sci. U.S.A.74:2584–2588, 1977.

    Google Scholar 

  74. Pannier, J. L., Weyne, J., Leusen, I.: The CSF blood potential and the regulation of the bicarbonate concentration of CSF during acidosis in the cat. Life Sci.10:287–300, 1971.

    Google Scholar 

  75. Pappenheimer, J. R.: The ionic composition of cerebral extracellular fluid and its relation to control of breathing. Harvey Lect.61:71–94, 1967.

    Google Scholar 

  76. Pappenheimer, J. R., Fencl, V., Heisey, S. R., Held, D.: Role of cerebral fluids in control of respiration as studied in unanesthetized goats. Am. J. Physiol.208:436–450, 1965.

    Google Scholar 

  77. Pappenheimer, J. R., Miller, T. B., Goodrich, C. A.: Sleep-promoting effects of cerebrospinal fluid from sleep-deprived goats. Proc. Natl. Acad. Sci. U.S.A.58:513–518, 1967.

    Google Scholar 

  78. Petrovicky, P.: Über die Glia marginalis und oberflachliche Nervenzellen im Hirnstamm der Katze. Z. Anat. Entwicklungsgesch.127:221–231, 1968.

    Google Scholar 

  79. Plum, F., Posner, J. B.: Blood and cerebrospinal fluid lactate during hyperventilation. Am. J. Physiol.212:864–870, 1967.

    Google Scholar 

  80. Pokorski, M.: Neurophysiological studies on central chemosensor in medullary ventrolateral areas. Am. J. Physiol.230:1288–1295, 1976.

    Google Scholar 

  81. Prill, R.: Des Verhalten von Neuronen des caudalen chemosensiblen Felds in der Medulla oblongata der Katze gegenuber intravenosen Injektionen von NaHCO3 und HCl. Thesis, Abteilung für Naturwissenschaftliche Medizin, Ruhr-Universitat Bochum, 1977.

    Google Scholar 

  82. Rall, D. P., Oppelt, W. W., Patlak, C. S.: Extracellular space of brain as determined by diffusion of inulin from the ventricular system. Life Sci.2:43–48, 1962.

    Google Scholar 

  83. Rosenstein, R., Mccarthy, L. E., Borison, H. L.: Respiratory effects of ethanol and procaine injected into the cerebrospinal fluid of the brainstem in cats. J. Pharmacol. Exp. Ther.162:174–181, 1968.

    Google Scholar 

  84. Schlaefke, M. E.: “Specific” and “non-specific” stimuli in the drive of respiration. Acta Neurobiol. Exp.33:149–154, 1973.

    Google Scholar 

  85. Schlaefke, M. E., See, W. R., Kille, J. F., Origin and afferent modification of respiratory drive from ventral medullary areas. In von Euler, C., and Lagercrantz, H. (eds.): Central Nervous Control Mechanisms in Breathing. Oxford, Pergamon Press, 1979, pp. 25–34.

    Google Scholar 

  86. Schlaefke, M. E., Kille, J., Folgering, H., Herker, A., See, W. R.: Breathing without central chemosensitivity. In Umbach, W., Koepchen, H. P. (eds.): Central Rhythmic and Regulation. Stuttgart, Hippokrates Verlag, 1974, pp. 97–104.

    Google Scholar 

  87. Schlaefke, M. E., Kille, J. F., Loeschcke, H. H.: Elimination of central chemosensitivity by coagulation of a bilateral area on the ventral medullary surface: Studies in awake cats. Pfluegers Arch.378:231–242, 1979.

    Google Scholar 

  88. Schlaefke, M. E., Loeschcke, H. H.: Lokalisation eines an der Regulation von Atmung und Kreislauf beteiligten Gebietes an der ventralen Oberfläche der Medulla oblongata durch Kalteblockade. Pfluegers Arch.297:201–220, 1967.

    Google Scholar 

  89. Schlaefke, M. E., Pokorski, M., See, W. R., Prill, R. K., Loeschcke, H. H.: Chemosensitive neurons on the ventral medullary surface. Bull. Physiopath. Resp.11:277–284, 1975.

    Google Scholar 

  90. Schlaefke, M. E., See, W. R.: Ventral surface stimulus response in relation to ventilatory and cardiovascular effects. In Koepchen, H. P., Hilton, S. M., Trzebski, A. (eds.): Central Interaction between Respiratory and Cardiovascular Control Systems. Berlin, Heidelberg, and New York, Springer-Verlag, 1980 (in press).

    Google Scholar 

  91. Schlaefke, M. E., See, W. R., Loeschcke, H. H.: Ventilatory response to alterations of H+ ion concentration in small areas of the ventral medullary surface. Respir. Physiol.10:198–212, 1970.

    Google Scholar 

  92. Schlaefke, M. E., See, W. R., Massion, W. H., Loeschcke, H. H.: Die Rolle spezifischer und unspezifischer Afferenzen fur den Antrieb der Atmung: Untersucht durch Reizung und Blockade von Afferenzen an der dezerebrierten Katze. Pfluegers Arch.312:189–205, 1969.

    Google Scholar 

  93. Schwanghardt, F., Schroter, R., Klussendorf, D., Koepchen, H. P.: Influence of novocaine block of superficial brain stem structures. In Umbach, W., Koepchen, H. P. (eds.): Central Rhythmic and Regulation, Stuttgart, Hippokrates Verlag, 1974, pp. 104–110.

    Google Scholar 

  94. See, W. R.: Respiratory drive in hyperthermia: Interaction with central chemosensitivity. In Loeschcke, H. H. (ed.): Acid-Base Homeostasis of the Brain Extracellular Fluid and the Respiratory Control System. Stuttgart, Georg Thieme, 1976, pp. 122–127.

    Google Scholar 

  95. See, W. R., Folgering, M., Schlaefke, M. E.: Central respiratory and cardiovascular effects of the ACH releaser 4-aminopyridine (r-AP). Pfluegers Arch.377:R20, 1978.

    Google Scholar 

  96. Sorensen, S. C: The chemical control of ventilation. Acta Physiol. Scand., Suppl. 371, 1971.

    Google Scholar 

  97. Stern, L. S., Gautier, E.: L’emploi de l’injection intraventriculaire comme methode d’etude de l’action directe des substances sur les centres nerveux. C. R. Soc. Biol.86:648–649, 1922.

    Google Scholar 

  98. Stern, L. S., Rozsine, J. A., Chuoles, G. J.: Le mechanisme de l’action du K et du Ca injectés dans les ventricules cerebraux. C. R. Soc. Biol.114:674–677, 1933.

    Google Scholar 

  99. Taber, E.: The cytoarchitecture of the brain stem of the cat. J. Comp. Neurol.116:27, 1961.

    Google Scholar 

  100. Terenius, L.: Endogenous peptides and analgesia. Annu. Rev. Pharmacol.18:189–204, 1978.

    Google Scholar 

  101. Trzebski, A., Majherczyk, P., Szulczyk, P., Chruscielewski, L.: Direct nervous mechanisms as the possible pathways of interaction of the central and peripheral chemosensitive areas. In Loeschcke, H. H. (ed.): Acid-Base Homeostasis of the Brain Extracellular Fluid and the Respiratory Control System. Stuttgart, Georg Thieme, 1945, pp. 130–145.

    Google Scholar 

  102. Wiemer, W.: Die Wirkung von Chemorezeptoren-Reizstoffen vom Liquor aus, Z. Biol.111:287–320, 1959.

    Google Scholar 

  103. Wiemer, W.: Zur Wirkung des Acetylcholins auf die Atmung. IV. Wirkung bei Injektion in die Cisterna pontis, Cisterna cerebellomedullaris, in den Seitenventrikel und den Liquor spinalis, Pfluegers Arch. Physiol.276:568–578, 1963.

    Google Scholar 

  104. Winterstein, H.: Die chemische Steurerung der Atmung. Ergeb. Physiol.48:328–528, 1955.

    Google Scholar 

  105. Winterstein, H., GöKhan, N.: Ammoniumchlorid-Acidose und Reaktionstheorie der Atmungsregulation. Arch. Int. Pharmacodyn.93:212–232, 1953.

    Google Scholar 

  106. Winterstein, H., GöKhan, N.: Chemoreceptoren Reizstoffe und Blut/Hirn-Schranke. Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol.219:192–196, 1953.

    Google Scholar 

  107. Winterstein, H., Wiemer, W.: Die Wirkung von Lobelin und Natriumcyanid bei suboccipitaler Injektion. Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol.235:235–242, 1959.

    Google Scholar 

  108. Wright, E. M.: Factors influencing the composition of the cerebrospinal fluid. In Loeschcke, H. H. (ed.): Acid-Base Homeostasis of the Brain Extracellular Fluid and the Respiratory Control System. Stuttgart, Georg Thieme, 1976, pp. 2–7.

    Google Scholar 

  109. Wright, E. M.: Transport processes in the formation of the cerebrospinal fluid. Rev. Physiol. Biochem. Pharmacol.83:1–34, 1978.

    Google Scholar 

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  1. Institut für Physiologie, Ruhr-Universität, Bochum, Germany

    Hans H. Loeschcke M.D.

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  1. Division of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    James H. Wood M.D. (Consultant) (Consultant)

  2. Pediatric Oncology Branch, National Cancer Institute National National Institutes of Health, Bethesda, Maryland, 20205, USA

    James H. Wood M.D. (Consultant) (Consultant)

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Loeschcke, H.H. (1980). Chemical Alterations of Cerebrospinal Fluid Acting on Respiratory and Circulatory Control Systems. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1039-6_3

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