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The Multidrug Resistance-Associated Protein — MRP

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Alternative Mechanisms of Multidrug Resistance in Cancer

Abstract

The development of the multidrug resistant (MDR) phenotype in cancer cells is the major obstacle to successful chemotherapy. Elucidation of the mechanisms that determine inherent resistance or chemotherapy-induced resistance of human tumors to many of the anticancer agents currently used in the clinic, is of great interest to researchers and great importance to patients. The MDR phenotype has classically been associated with the overexpression of the transmembrane energy-dependent P-glycoprotein transporter coded for by the mdr1 gene (Kartner et al. 1983; Pastan and Gottesman 1987; Bradley et al. 1988; Endicott and Ling 1989; Biedler 1994). However, the frequent findings of certain cancer cell lines possessing an MDR phenotype but lacking the overexpression of P-glycoprotein, prompted scientists to search for other potential molecules which could be responsible for an increased resistance to structurally unrelated chemotherapeutic drugs (McGrath and Center 1987; Cole et al. 1989; Haber et al. 1989; Baas et al. 1990; Coley et al. 1991; Versantvoort et al. 1992; Jachez and Loor 1993; Hill and Hosking 1994).

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Authors
  1. Dominic Fan
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  2. Diane R. Bielenberg
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  3. Yun-Fang Wang
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  4. Robert Radinsky
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  5. Pedro J. Beltran
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Editor information

Editors and Affiliations

  1. Sunnybrook Health Science Center, University of Toronto, Toronto, Canada, M4N 3M5

    John A. Kellen

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© 1995 Birkhäuser Boston

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Fan, D., Bielenberg, D.R., Wang, YF., Radinsky, R., Beltran, P.J. (1995). The Multidrug Resistance-Associated Protein — MRP. In: Kellen, J.A. (eds) Alternative Mechanisms of Multidrug Resistance in Cancer. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9852-7_4

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  • DOI: https://doi.org/10.1007/978-1-4615-9852-7_4

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4615-9854-1

  • Online ISBN: 978-1-4615-9852-7

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