Abstract
Human plasma high density lipoprotein (HDL) contains approximately 45% protein and 65% lipid by weight. Among lipids cholesterol esters and phospholipids are major constituent, apolipoprotein A-I and apolipoprotein A-II account for 60 and 30% about of the HDL protein mass (1). Apolipoprotein A-I is synthetized as pre-proapoprotein; the pre-peptide is cleaved cotranslationally, while the proapo A- I is apparently secreted as such mainly by the intestine and liver (2). Conversion to the mature form (243 aminoacids) occurs in plasma via a specific enzyme that cleaves the pro (6 aminoacid) segment.
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© 1989 Plenum Press, New York
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Catapano, A.L., Marcovina, S. (1989). Monoclonal Antibodies to Human Apolipoprotein A-I. In: Sirtori, C.R., Franceschini, G., Brewer, H.B., Assmann, G. (eds) Human Apolipoprotein Mutants 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9549-6_28
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DOI: https://doi.org/10.1007/978-1-4615-9549-6_28
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