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Human Apolipoprotein Mutants 2

From Gene Structure to Phenotypic Expression

  • C. R. Sirtori
  • G. Franceschini
  • H. B. BrewerJr.
  • G. Assmann

Table of contents

  1. Front Matter
    Pages i-xii
  2. Evolution and Control of Gene Expression

    1. W. Stoffel, E. Binczek, A. Haase, C. Holtfreter
      Pages 17-29
    2. Marco Soria, Antonella Isacchi, Rolando Lorenzetti, Lucia Monaco, Raffaele Palomba, Paolo Sarmientos
      Pages 39-44
  3. High Density Lipoproteins and Apo AI-Milano

    1. Guido Franceschini, Laura Calabresi, Massimo Baio, Alex V. Nichols, Cesare R. Sirtori
      Pages 45-50
    2. P. Roma, R. E. Gregg, M. Meng, C. Bishop, R. Ronan, L. A. Zech et al.
      Pages 51-57
    3. Alex V. Nichols, Marian C. Cheung, Patricia J. Blanche, Elaine L. Gong, Guido Franceschini, Cesare R. Sirtori
      Pages 67-73
  4. Apolipoprotein B

    1. Philippa Talmud, Richard Houlston, Alison Dunning, Steve Humphries
      Pages 75-80
    2. Philippa J. Talmud, June Lloyd, David Muller, David R. Collins, James Scott, Steve Humphries
      Pages 81-84
    3. F. Turturro, J. Heibig, G. C. Ghiselli, A. M. Gotto Jr.
      Pages 85-93
    4. R. Infante
      Pages 95-108
  5. Apolipoprotein C-II and C-III

    1. S. S. Fojo, U. Beisiegel, A. F. H. Stalenhoef, M. Bojanovski, R. E. Gregg, H. Greten et al.
      Pages 109-119
    2. G. Pepe, C. Crecchio, A. Tullo, A. M. Mogavero, M. De Tommaso, A. Capurso
      Pages 137-141
    3. Jose M. Ordovas, Dianne C. King, Ernst J. Schaefer
      Pages 157-159
  6. Dyslipoproteinemias, Coronary Artery Disease and Diabetes

    1. Philip Connelly, Graham McGuire, Maureen Lee, Ruth McPherson, Alick Little
      Pages 161-165
    2. G. Schmitz, H. Robenek, B. Brennhausen, G. Assmann
      Pages 167-174
    3. Louis M. Havekes, Peter de Knijff, Jan Gevers Leuven, Rune R. Frants
      Pages 175-180
    4. C. Gabelli, G. Baggio, A. Pagnan, G. Zanetti, G. M. Barbato, S. Martini et al.
      Pages 181-188
    5. Giancarlo Ghiselli, Ellison Wittels, Jacques Heibig, Antonio M. Gotto Jr.
      Pages 189-206
    6. U. Beisiegel, G. Ihrke, W. Weber, P. Lohse, H. Greten
      Pages 207-209
  7. Lipoprotein Structure: Immunological Methods

    1. M. Rosseneu, J. M. Ruysschaert, M. Froeyen, R. Brasseur
      Pages 215-220
    2. Alberico L. Catapano, Santica Marcovina
      Pages 221-227
    3. Y. L. Marcel, L. Leblond, E. A. Raffai, D. Jewer, P. K. Weech, R. W. Milne
      Pages 229-233
    4. Alberto Corsini, Simona Fantappiè, Santica Marcovina, Agnese Granata, Remo Fumagalli, Alberico L. Catapano
      Pages 235-240
    5. P. Duriez, A. Dunning, N. Vu Dac, F. Monard-Herkt, H. Parra, S. Humphries et al.
      Pages 241-250
  8. Back Matter
    Pages 251-255

About this book

Introduction

The pleasant community of Limone suI Garda provided outstanding hospitality for a second NATO ARW dealing with apolipoprotein variants, which are natures clues for the discovery of the physiological roles of apolipoproteins in lipoprotein metabolism in normal subjects and patients with specific dyslipoproteinemias. Limone, the site of discovery of the first human apolipoprotein mutant, apoA-I-Milano, provided a brilliant sunny spring venue for more than 50 participants from both sides of the ocean. The attendance at the colorful opening ceremony of the ARW was one of the largest on record. Two members of the Italian government, the Secretaries of Health and the Navy, gave the welcoming addresses. Six television networks, two with national audiences, covered the international workshop. The Limone oracles provided a montage of insights gleamed from the eyes of the clinican, the biochemist, and the molecular biologist. The cumulative information on the molecular defects in lipoprotein metabolism reviewed by this diverse group of investigators provided an ever expanding horizon of new knowledge in this fast moving and some times perplexing field. Clinical vignettes were presented on patients from throughout the world including Canada (Connelly), Turkey (Schmitz), and France (Infante) detailing the clinical sequelae of a defect in a specific apolipoprotein. The clinical importance of Lp(a), a lipoprotein relegated almost to obscurity for many years, has now taken v center stage.

Keywords

DNA Lipid gene gene expression lipoprotein metabolism mutant mutation ocean protein protein structure proteins receptor structure synthesis

Editors and affiliations

  • C. R. Sirtori
    • 1
  • G. Franceschini
    • 1
  • H. B. BrewerJr.
    • 2
  • G. Assmann
    • 3
  1. 1.Institute of Pharmacological SciencesUniversity of MilanMilanItaly
  2. 2.National Heart, Lung, and Blood InstituteNational Institutes of HealthBethesdaUSA
  3. 3.University of MünsterMünsterFederal Republic of Germany

Bibliographic information